Essence of the monitoring system for managing project life cycle at an instrument-making holding

The article examines the issues the monitoring system for managing project life cycle at an instrument-making holding project. The purpose of monitoring is to improve the project management system, identify discrepancies between actual and planned indicators, monitor the project indicators, change the organisation strategy development, proposals to eliminate potential threats. The main tasks adopted as monitoring-screening tools are the identification of key indicators; processing and aggregation of critically necessary information about specific project tasks; identification of external and internal risks; attractors that strongly influence the implementation of the project; issue of operational reports on the project; forecasting and decision-making, development of proposals to correct negative situations; ensuring the integration of the monitoring system in the information environment of the holding. The article reveals the key problems in this area and outlines conceptual directions for improving the process under study. The relevance of the material is the activity of a real specialist directly inside the dynamic structure of the holding, who knows all the old management methods and models new and redundant management methods, updating them in accordance with external and internal challenges. The experience of implementing the project of changing management paradigms during the crisis can be used to minimise further risks and accelerate the choice of effective management methods in organisations of large holdings, which, in turn, will allow you to reorient yourself as painlessly as possible to new management mechanisms that will contribute to more efficient operation of the holding as a whole

Intrinsic coagulation cascade factors and hemostatic markers of endothelial dysfunction in patients with peripheral artery disease

АРТЕРИОСКЛЕРОЗ ОБЛИТЕРИРУЮЩИЙВНУТРЕННИЙ КАСКАД КОАГУЛЯЦИИГЕМОСТАТИЧЕСКИЕ МАРКЕРЫДИСФУНКЦИЯ ЭНДОТЕЛИЯАЗОТА ОКСИДЫАЗОТА ОКИСЬАЗОТА (II) ОКСИДВИЛЛЕБРАНДА ФАКТОРСОСУДИСТЫЕ ХИРУРГИЧЕСКИЕ ОПЕРАЦИИЦель. Оценка активности факторов внутреннего каскада коагуляции и гемостатических маркеров дисфункции эндотелия у пациентов с облитерирующим атеросклерозом артерий нижних конечностей (ОААНК) до и после эндоваскулярных вмешательств. Материал и методы. В исследование было включено 80 пациентов с ОААНК IIБ-III стадии по А. В. Покровскому-Фонтейну. 40 пациентов с ОААНК подверглись эндоваскулярным вмешательствам на аорто-бедренно-подколенном сегменте (группа А), и 40 пациентов прошли консервативное лечение (группа В). Пациентам было проведено физикальное обследование, ультразвуковая допплерография (УЗДГ), дуплексное сканирование (УЗДС)/рентгеноконтрастная ангиография артерий нижних конечностей. Через 3 и 6 месяцев после проведенного лечения пациенты повторно прошли физикальное обследование, УЗДГ и УЗДС артерий нижних конечностей. При включении пациентов в исследование и через 3 месяца после операции были взяты образцы венозной крови для оценки активности факторов VIII, IХ, ХI, фактора фон Виллебранда (ФВ), оксида азота II (NO) и протеина С (ПрС). Результаты. У пациентов группы А до оперативного вмешательства средние значения активности VIII, IX, XI факторов и ФВ были повышены по сравнению с нормой. Через 3 месяца после операции наблюдался еще больший рост активности VIII, IX, XI факторов, сохранялся повышенный уровень ФВ при снижении показателей метаболитов NO. У пациентов группы В были повышены средние значения активности IX, XI факторов, ФВ при нормальном уровне метаболитов NO и ПрС. Заключение. Анализ исходного состояния системы гемостаза у пациентов с ОААНК позволяет сделать вывод о развитии гиперкоагуляционного состояния на фоне нормального антикоагуляционного потенциала. Оперативное вмешательство способствует еще большему сдвигу в сторону гиперкоагуляции и нарушению функционального состояния эндотелия.Objective. To assess the activity of intrinsic coagulation cascade factors of coagulation and hemostatic markers of endothelial dysfunction in patients with atherosclerotic peripheral artery disease (PAD) before and after endovascular treatment. Methods. The study included 80 patients with PAD in the stage IIB-III of the disease according to Pokrovsky-Fontaine classification. 40 patients with PAD underwent endovascular interventions on the femoropopliteal segment (group A) and 40 patients underwent the conservative treatment (group B). Patients underwent physical examination, ankle-brachial index measurement (ABI), duplex ultrasound (DUS) and digital substraction angiography. 3 and 6 months after treatment patients underwent the same procedures. At inclusion of patients in the study and 3 months after the surgery, peripheral venous blood samples were collected to assess the activity of VIII, IX, XI, von Willebrand factor (VWF), protein С (PrC) and metabolites of nitric oxide II (NO). Results. In patients of the group А mean values of activity VIII, IX, XI factors and VWF were increased in comparison with the norm before the surgery. After 3 months the results shown a greater increase in activity VIII, IX, XI factors, the elevated levels of VWF remained in the reduction of NO metabolites. In patients of the group B the mean activity values of IX, XI factors and VWF were increased with normal levels of NO metabolites and PrC. Conclusions. The analysis of the initial state of the hemostasis system in patients with atherosclerotic peripheral artery disease allows us to conclude that the hypercoagulable state develops against the background of a normal anticoagulation potential. Operative procedures provide a further shift towards a hypercoagulable state and impaired functional activity of endothelium

MEASUREMENTS OF NEUTRON RADIATION SPECTRA AT NUCLEAR POWER PLANTS WITH PWR

This paper presents data on the reconstruction of neutron spectra. The energy and angular distribution of neutrons have been estimated. Correction factors for individual dosimeters have been calculated

On the methodology for assessing the quality of telemedicine services in the doctor-doctor system

The objective was to develop a system of indicators of telemedicine services in the "doctor – doctor" system in order to improve the quality of the organization of remote interaction between medical organizations in providing medical care using telemedical technologies.Цель работы – разработать систему показателей телемедицинских услуг в системе «врач – врач» с целью повышения качества организации дистанционного взаимодействия между медицинскими организациями при оказании медицинской помощи с применением телемедицинских технологий

Cyclic Methacrylate Tetrahydropyrimidinones: Synthesis, Properties, (Co)Polymerization

During radical polymerization of novel biocidal methacrylate guanidine monomers, a cyclic byproduct was discovered and identified as 2-imino-5-methyltetrahydropyrimidin-4(1H)-one (THP). Its methacrylate salt (MTHP) was synthesized and characterized via 1H and 13C NMR and pyrolysis chromatography. Synthesis conditions of both THP and MTHP were optimized to high yields, and both MTHP homopolymerization (in aqua) and copolymerization with diallyldimethylammonium chloride (in aqua in salt form) were successfully carried out with middle to high yields, providing a promising platform for potential tailored biocide polymers

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Purpose: We aimed to evaluate the impact of intrinsic coagulation factors and hemostatic markers of endothelial dysfunction on complications in patients with atherosclerotic peripheral arterial disease (PAD). Materials and Methods : This prospective study enrolled 120 PAD patients at Fontaine stages 2b to 3 who underwent open surgical, endovascular, or conservative treatment. Coagulation factors (FVIII, FIX, and FXI) and endothelial hemostatic markers, including von Willebrand factor (vWF) activity and level, soluble endothelial protein C receptor, and plasminogen activator inhibitor-1 (PAI-1) levels, were assessed. Results : At 3 months after open bypass grafting, activity of FVIII significantly increased from a median of 175% to 233% (P<0.001). At 3 months after endovascular treatment, the activities of FVIII, FIX, and FXI significantly increased from medians of 157%, 180%, and 156% to 184%, 218%, and 181%, respectively (P<0.05). Six patients with increased FVIII activity developed bypass graft thrombosis. Four patients in the endovascular group and three patients in the conservative treatment group with increased activity of vWF developed myocardial infarction (P=0.049). The subjects who developed restenosis had increased vWF activity (P=0.023) and decreased nitric oxide metabolite levels (P=0.003). Three subjects who received conservative treatment and developed PAD progression at 12 months had increased PAI-1 activity (P=0.028). Conclusion : Patients with advanced PAD had a hypercoagulable status, and performance of open or endovascular revascularization was associated with further hypercoagulability. Increased activity of coagulation factors and altered levels of hemostatic markers of endothelial dysfunction were associated with PAD complications such as graft thrombosis, myocardial infarction, disease progression, and restenosis