An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment

AgNO₂ as the NO Source for the Synthesis of Substituted Pyrazole <i>N</i>‑Oxides from <i>N</i>‑Propargylamines

A straightforward method for synthesizing the pyrazole <i>N</i>-oxides from <i>N</i>-propargylamines and AgNO₂ through oxidation/cyclization reaction had been developed. AgNO₂ was used as the NO source for the first time to synthesize pyrazole <i>N</i>-oxides. Various substituted groups on <i>N</i>-propargylamines proceeded smoothly, and the desired products were obtained in good yields

AgNO₂ as the NO Source for the Synthesis of Substituted Pyrazole <i>N</i>‑Oxides from <i>N</i>‑Propargylamines

A straightforward method for synthesizing the pyrazole <i>N</i>-oxides from <i>N</i>-propargylamines and AgNO₂ through oxidation/cyclization reaction had been developed. AgNO₂ was used as the NO source for the first time to synthesize pyrazole <i>N</i>-oxides. Various substituted groups on <i>N</i>-propargylamines proceeded smoothly, and the desired products were obtained in good yields

An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment

Estimating mangrove above-ground biomass at Maowei Sea, Beibu Gulf of China using machine learning algorithm with Sentinel-1 and Sentinel-2 data

Blue carbon ecosystems such as mangroves are natural barriers to resisting and alleviating the impact of storm surges and extreme catastrophic weather. Accurate and efficient determination of the aboveground biomass of mangroves is of great importance for the protection and restoration of blue carbon ecosystems and their response to climate change. This study proposes a light gradient boosting model (LGBM) based on particle swarm optimization (PSO) algorithm for feature selection. We constructed and verified the proposed model using 227 quadrat datasets from a field survey and Sentinel-1 and Sentinel-2 data. The determination coefficient (R2) and root-mean-square error (RMSE) were used to evaluate the performance of the model. Compared with random forest(RF), K-nearest neighbourhood regression(KNNR), extreme gradient boosting(XGBR), LGBM, and other machine learning algorithms, the LGBM-PSO model achieves better results (R2 = 0.7807, RMSE = 24.6864 Mg·ha−1), The predicted range of mangrove biomass is 4.623–206.975 Mg·ha−1. Therefore, the use of multisource remote sensing data combined with the LGBM-PSO model can provide better prediction results of aboveground biomass of mangroves, thereby providing a new method for estimating the aboveground biomass of large-scale mangroves

An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment