Microwave-improved polymerization of ε-caprolactone initiated by carboxylic acids

The ring-opening polymerization of e-caprolactone (B-CL), initiated by carboxylic acids such as benzoic acid and chlorinated acetic acids under microwave irradiation, was investigated; with this method, no metal catalyst was necessary. The product was characterized as poly(epsilon-caprolactone) (PCL) by H-1 NMR spectroscopy, Fourier transform infrared spectroscopy, ultraviolet spectroscopy, and gel permeation chromatography. The polymerization was significantly improved under microwave irradiation. The weight-average molecular weight (M-w) of PCL reached 44,800 g/mol, with a polydispersity index [weight-average molecular weight/number-average molecular Weight (M-w/M-n)] of 1.6, when a mixture of epsilon-CL and benzoic acid (25/1 molar ratio) was irradiated at 680 W for 240 min, whereas PCL with M-w = 12,100 and M-w/M-n = 4.2 was obtained from the same mixture by a conventional heating method at 210 degreesC for 240 min. A degradation of the resultant PCL was observed during microwave polymerization with chlorinated acetic acids as initiators, and this induced a decrease in M-w of PCL. However, the degradation was hindered by benzoic acid at low concentrations. (C) 2002 Wiley Periodicals, Inc

Series expansions of the percolation probability for directed square and honeycomb lattices

We have derived long series expansions of the percolation probability for site and bond percolation on directed square and honeycomb lattices. For the square bond problem we have extended the series from 41 terms to 54, for the square site problem from 16 terms to 37, and for the honeycomb bond problem from 13 terms to 36. Analysis of the series clearly shows that the critical exponent $\beta$ is the same for all the problems confirming expectations of universality. For the critical probability and exponent we find in the square bond case, $q_c = 0.3552994\pm 0.0000010$, $\beta = 0.27643\pm 0.00010$, in the square site case $q_c = 0.294515 \pm 0.000005$, $\beta = 0.2763 \pm 0.0003$, and in the honeycomb bond case $q_c = 0.177143 \pm 0.000002$, $\beta = 0.2763 \pm 0.0002$. In addition we have obtained accurate estimates for the critical amplitudes. In all cases we find that the leading correction to scaling term is analytic, i.e., the confluent exponent $\Delta = 1$.Comment: LaTex with epsf, 26 pages, 2 figures and 2 tables in Postscript format included (uufiled). LaTeX version of tables also included for the benefit of those without access to PS printers (note that the tables should be printed in landscape mode). Accepted by J. Phys.

The upstream magnetic field of collisionless GRB shocks: constraint by Fermi-LAT observations

Long-lived >100 MeV emission has been a common feature of most Fermi-LAT detected gamma-ray bursts (GRBs), e.g., detected up to ~10^3s in long GRBs 080916C and 090902B and ~10^2s in short GRB 090510. This emission is consistent with being produced by synchrotron emission of electrons accelerated to high energy by the relativistic collisionless shock propagating into the weakly magnetized medium. Here we show that this high-energy afterglow emission constrains the preshock magnetic field to satisfy 1(n/1cc)^{9/8} mG<B<10^2(n/1cc)^{3/8}mG, where n is the preshock density, more stringent than the previous constraint by X-ray afterglow observations on day scale. This suggests that the preshock magnetic field is strongly amplified, most likely by the streaming of high energy shock accelerated particles.Comment: 9 pages, JCAP accepte

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.

Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility of selected differentially expressed miRNAs in the serum as potential OA biomarkers. Methods: Serum samples were collected from 12 primary OA patients, and 12 healthy individuals were screened using the Agilent Human miRNA Microarray platform interrogating 2549 miRNAs. Receiver Operating Characteristic (ROC) curves were constructed to evaluate the diagnostic performance of the deregulated miRNAs. Expression levels of selected miRNAs were validated by quantitative real-time PCR (qRT-PCR) in all serum and in articular cartilage samples from OA patients (n = 12) and healthy individuals (n = 7). Bioinformatics analysis was used to investigate the involved pathways and target genes for the above miRNAs. Results: We identified 279 differentially expressed miRNAs in the serum of OA patients compared to controls. Two hundred and five miRNAs (73.5%) were upregulated and 74 (26.5%) downregulated. ROC analysis revealed that 77 miRNAs had area under the curve (AUC) > 0.8 and p < 0.05. Bioinformatics analysis in the 77 miRNAs revealed that their target genes were involved in multiple signaling pathways associated with OA, among which FoxO, mTOR, Wnt, pI3K/akt, TGF-β signaling pathways, ECM-receptor interaction, and fatty acid biosynthesis. qRT-PCR validation in seven selected out of the 77 miRNAs revealed 3 significantly downregulated miRNAs (hsa-miR-33b-3p, hsa-miR-671-3p, and hsa-miR-140-3p) in the serum of OA patients, which were in silico predicted to be enriched in pathways involved in metabolic processes. Target-gene analysis of hsa-miR-140-3p, hsa-miR-33b-3p, and hsa-miR-671-3p revealed that InsR and IGFR1 were common targets of all three miRNAs, highlighting their involvement in regulation of metabolic processes that contribute to OA pathology. Hsa-miR-140-3p and hsa-miR-671-3p expression levels were consistently downregulated in articular cartilage of OA patients compared to healthy individuals. Conclusions: A serum miRNA signature was established for the first time using high density resolution miR-arrays in OA patients. We identified a three-miRNA signature, hsa-miR-140-3p, hsa-miR-671-3p, and hsa-miR-33b-3p, in the serum of OA patients, predicted to regulate metabolic processes, which could serve as a potential biomarker for the evaluation of OA risk and progression.Peer reviewedFinal Published versio

Conditions for the freezing phenomena of geometric measure of quantum discord for arbitrary two-qubit X states under non-dissipative dephasing noises

We study the dynamics of geometric measure of quantum discord (GMQD) under the influences of two local phase damping noises. Consider the two qubits initially in arbitrary X-states, we find the necessary and sufficient conditions for which GMQD is unaffected for a finite period. It is further shown that such results also hold for the non-Markovian dephasing process.Comment: 4 pages, 2 figure

Interacting model of new agegraphic dark energy: observational constraints and age problem

Many dark energy models fail to pass the cosmic age test because of the old quasar APM 08279+5255 at redshift $z=3.91$, the $\Lambda$CDM model and holographic dark energy models being no exception. In this paper, we focus on the topic of age problem in the new agegraphic dark energy (NADE) model. We determine the age of the universe in the NADE model by fitting the observational data, including type Ia supernovae (SNIa), baryon acoustic oscillations (BAO) and the cosmic microwave background (CMB). We find that the NADE model also faces the challenge of the age problem caused by the old quasar APM 08279+5255. In order to overcome such a difficulty, we consider the possible interaction between dark energy and dark matter. We show that this quasar can be successfully accommodated in the interacting new agegraphic dark energy (INADE) model at the $2\sigma$ level under the current observational constraints.Comment: 12 pages, 5 figures; typos corrected; version for publication in SCIENCE CHINA Physics, Mechanics & Astronom

Synthesis, Characterization, and Microwave Absorption Property of the SnO2Nanowire/Paraffin Composites

In this article, SnO2nanowires (NWs) have been prepared and their microwave absorption properties have been investigated in detail. Complex permittivity and permeability of the SnO2NWs/paraffin composites have been measured in a frequency range of 0.1–18 GHz, and the measured results are compared with that calculated from effective medium theory. The value of maximum reflection loss for the composites with 20 vol.% SnO2NWs is approximately −32.5 dB at 14 GHz with a thickness of 5.0 mm

Requirement of Mouse BCCIP for Neural Development and Progenitor Proliferation

Multiple DNA repair pathways are involved in the orderly development of neural systems at distinct stages. The homologous recombination (HR) pathway is required to resolve stalled replication forks and critical for the proliferation of progenitor cells during neural development. BCCIP is a BRCA2 and CDKN1A interacting protein implicated in HR and inhibition of DNA replication stress. In this study, we determined the role of BCCIP in neural development using a conditional BCCIP knock-down mouse model. BCCIP deficiency impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly. These development defects are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. With in vitro neural spheroid cultures, BCCIP deficiency impaired neural progenitor's self-renewal capability, and spontaneously activated p53. These data suggest that BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors

MARBLE: Music Audio Representation Benchmark for Universal Evaluation

In the era of extensive intersection between art and Artificial Intelligence (AI), such as image generation and fiction co-creation, AI for music remains relatively nascent, particularly in music understanding. This is evident in the limited work on deep music representations, the scarcity of large-scale datasets, and the absence of a universal and community-driven benchmark. To address this issue, we introduce the Music Audio Representation Benchmark for universaL Evaluation, termed MARBLE. It aims to provide a benchmark for various Music Information Retrieval (MIR) tasks by defining a comprehensive taxonomy with four hierarchy levels, including acoustic, performance, score, and high-level description. We then establish a unified protocol based on 14 tasks on 8 public-available datasets, providing a fair and standard assessment of representations of all open-sourced pre-trained models developed on music recordings as baselines. Besides, MARBLE offers an easy-to-use, extendable, and reproducible suite for the community, with a clear statement on copyright issues on datasets. Results suggest recently proposed large-scale pre-trained musical language models perform the best in most tasks, with room for further improvement. The leaderboard and toolkit repository are published at this https URL to promote future music AI research