CYCLOADDITION OF 1,4-CNCO DIPOLES GENERATED FROM DIPYRAZOLODIOXADIAZOCINES

This work was supported by the Russian Science Foundation, project # 19-13-00290

Regiodivergent dipolar cycloaddition based on pyrrole-2,3-diones

It was previously demonstrated, that thermal decarbonylation of N-substituted 2,3-dihydro-2,3-pyrroldiones afforded imidoylketenes, whose chemical behavior largely depends on the nature of substituents at N-1. It was discovered that N-(diphenylenamino)pyrrolediones experienced facile CO-extrusion at elevated temperatures and the resulting a zwitterionic dihydropyrazolone species, which can be represented by enolate-iminium 1,4-dipole resonance form. In the absence of dipolarophiles, the products of [4+4]-cyclodimerization – bis(pyrazolo)dioxadiazocines – were formed in high yields. To this end, we generated the ketenes in the presence of alkyl vinyl ethers, aldehydes, ketenes, nitriles and isocyanides targeting products of dipolar cycloadditions. We further elaborated on the development of various synthetic schemes involving cycloaddition of these unusual 1,4-dipoles. Dipyrazolodioxadiazocines are shelf-stable "ready-to-use" precursors for an in situ generation of enolate-iminium 1,4-dipoles.This work was supported by the Russian Science Foundation, project № 19-13-00290

Measurement of J/ψ→γηcJ/\psi\to\gamma\eta_{\rm c} decay rate and ηc\eta_{\rm c} parameters at KEDR

Using the inclusive photon spectrum based on a data sample collected at the $J/\psi$ peak with the KEDR detector at the VEPP-4M $e^+e^-$ collider, we measured the rate of the radiative decay $J/\psi\to\gamma\eta_{\rm c}$ as well as $\eta_{\rm c}$ mass and width. Taking into account an asymmetric photon lineshape we obtained $\Gamma^0_{\gamma\eta_{\rm c}}=2.98\pm0.18 \phantom{|}^{+0.15}_{-0.33}$ keV, $M_{\eta_{\rm c}} = 2983.5 \pm 1.4 \phantom{|}^{+1.6}_{-3.6}$ MeV/$c^2$, $\Gamma_{\eta_{\rm c}} = 27.2 \pm 3.1 \phantom{|}^{+5.4}_{-2.6}$ MeV.Comment: 6 pages, 3 figure

Measurement of J/psi to eta_c gamma at KEDR

We present a study of the inclusive photon spectra from 5.9 million J/psi decays collected with the KEDR detector at the VEPP-4M e+e- collider. We measure the branching fraction of radiative decay J/psi to eta_c gamma, eta_c width and mass. Our preliminary results are: M(eta_c) = 2979.4+-1.5+-1.9 MeV, G(eta_c) = 27.8+-5.1+-3.3 MeV, B(J/psi to eta_c gamma) = (2.34+-0.15+-0.40)%.Comment: To be published in Proceedings of the PhiPsi09, Oct. 13-16, 2009, Beijing, Chin

Measurement of B(J/psi->eta_c gamma) at KEDR

We present a study of the inclusive photon spectrum from 6.3 million J/psi decays collected with the KEDR detector at the VEPP-4M e+e- collider. We measure the branching fraction of the radiative decay J/psi -> eta_c gamma, eta_c width and mass. Taking into account an asymmetric photon line shape we obtain: M(eta_c) = (2978.1 +- 1.4 +- 2.0) MeV/c^2, Gamma(eta_c) = (43.5 +- 5.4 +- 15.8) MeV, B(J/psi->eta_c gamma) = (2.59 +- 0.16 +- 0.31)%$.Comment: 6 pages, 1 figure. To be published in the proceedings of the 4th International Workshop on Charm Physics (Charm2010), October 21-24, 2010, IHEP, Beijin

Precise measurement of RudsR_{\text{uds}} and RR between 1.84 and 3.72 GeV at the KEDR detector

The present work continues a series of the KEDR measurements of the $R$ value that started in 2010 at the VEPP-4M $e^+e^-$ collider. By combining new data with our previous results in this energy range we measured the values of $R_{\text{uds}}$ and $R$ at nine center-of-mass energies between 3.08 and 3.72 GeV. The total accuracy is about or better than $2.6\%$ at most of energy points with a systematic uncertainty of about $1.9\%$. Together with the previous precise $R$ measurement at KEDR in the energy range 1.84-3.05 GeV, it constitutes the most detailed high-precision $R$ measurement near the charmonium production threshold.Comment: arXiv admin note: text overlap with arXiv:1610.02827 and substantial text overlap with arXiv:1510.0266

A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease

We previously showed that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 alleviates motor manifestations of Parkinson's disease in animal models. In the present study, we designed and synthesized monoepoxides of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 and evaluated their biological activity in the MPTP mouse model of Parkinson's disease. We also assessed the ability of these compounds to penetrate the blood-brain barrier (BBB). According to these data, we chose epoxide 4, which potently restored the locomotor activity in MPTP-treated mice and efficiently penetrated the BBB, to further explore its potential mechanism of action. Epoxide 4 was found to robustly promote the survival of cultured dopamine neurons, protect dopamine neurons against toxin-induced degeneration, and trigger the mitogen-activated protein kinase (MAPK) signaling cascade in cells of neuronal origin. Meanwhile, neither the survival-promoting effect nor MAPK activation was observed in non-neuronal cells treated with epoxide 4. In the MPTP mouse model of Parkinson's disease, compound 4 increased the density of dopamine neuron fibers in the striatum, which can highlight its potential to stimulate striatal reinnervation and thus halt disease progression. Taken together, these data indicate that epoxide 4 can be a promising compound for further development, not only as a symptomatic but also as a neuroprotective and neurorestorative drug for Parkinson's disease.Peer reviewe

Study of the process e+e−→ωπ0→π+π−π0π0e^+e^- \to \omega\pi^0 \to \pi^+\pi^-\pi^0\pi^0 in the energy range 1.05−2.001.05-2.00 GeV with SND

The process $e^+e^- \to \omega\pi^0 \to \pi^+\pi^-\pi^0\pi^0$ is studied in the center-of-mass energy region $1.05-2.00$ GeV using data with an integral luminosity of about 35 pb$^{-1}$ collected with the SND detector at the VEPP-2000 $e^+e^-$ collider. In the energy range under study, the value of the measured Born cross section varies from 0.7 to 18 nb. The statistical uncertainty of the cross section is $2-23$%, while the systematic uncertainty is in the range of $3.0-14.2$%. The results are consistent with previous measurements but have better accuracy.Comment: 13 pages, 11 figure