Effect of carbamylated darbepoetin administration at different doses on the thymus and spleen structure of rats

In this article, the morphological features of the structure of the thymus and spleen under the influence of carbamylated darbepoetin in different doses were studied. The material for the study was 40 white male rats of the Wistar bree

The cardio- and endothelial protective effects of ethyl methyl hydroxyl pyridine malate in modeling L-name induced nitric oxide deficiency

Currently, endothelial dysfunction is considered as a predictor of a number of pathologies, including arterial hypertension, ischemic heart disease, chronic heart failure, and is also a pathogenetic component of organ damage in diabetes, hypo estrogenic and other conditions. The purpose of the study is an experimental study of the cardio and vasoprotective effects of etoxidol under conditions of endothelial dysfunctio

Pharmacological screening antihypoxic and cytoprotective properties of mexidol and analogs of human erythropoietin in cultured leukocytes of pigs

The article outlines improved methodological approaches to preclinical screening of antihypoxic and cytoprotective drugs. To investigate the effect of Mexidol, carbamylated darbepoetin, darbepoetin, and placebo (isotonic solution for the substance) against the background of hypoxic and cytotoxic effects on cell culture. Get data on the cytoprotective and antihypoxic therapeutic corridor of Mexido

Pharmacological screening antihypoxic and cytoprotective properties of mexidol and analogs of human erythropoietin in cultured leukocytes of pigs

The article outlines improved methodological approaches to preclinical screening of antihypoxic and cytoprotective drugs. To investigate the effect of Mexidol, carbamylated darbepoetin, darbepoetin, and placebo (isotonic solution for the substance) against the background of hypoxic and cytotoxic effects on cell culture. Get data on the cytoprotective and antihypoxic therapeutic corridor of Mexido

Electric calciner control in the production of carbon products

Жученко, О. А. Постановка задачі керування електрокальцинатором у виробництві вуглецевих виробів / О. А. Жученко, М. Г. Хібеба // Вісник Приазовського державного технічного університету : зб. наукових праць / ПДТУ. – Маріуполь, 2017. – Вип. 34. – С. 148–154. – (Серія : Технічні науки).Виконано порівняльний аналіз техніко-економічних показників як критеріїв оптимального керування електрокальцинатором. Визначено, що використання розглянутих показників має недоліки, пов’язані з особливостями виробництва. Запропоновано використання модифікованого показника питомої собівартості експлуатаційних витрат як такого, що дозволяє найбільш повно оцінити ефективність процесу термообробки вуглецевої сировини в електрокальцинаторі. Проведено постановку задачі керування електрокальцинатором у виробництві вуглецевих виробів.Выполнен сравнительный анализ технико-экономических показателей как критериев оптимального управления электрокальцинатором. Определено, что использование рассмотренных показателей имеет недостатки, связанные с особенностями производства. Предложено использование модифицированного показателя удельной себестоимости эксплуатационных расходов как такового, что позволяет наиболее полно оценить эффективность процесса термообработки углеродного сырья в электрокальцинаторе. Проведено постановку задачи управления электрокальцинатором в производстве углеродных изделий.A comparative analysis of technical and economic indicators as criteria for optimal electric calciner control has been done. It is shown that the use of the considered factors has some drawbacks resulting from the operating conditions. The modified factor of specific operating costs as the factor, that makes it possible to fully evaluate heat treatment of carbon materials in electric calciner efficiency has been proposed. The use of the electric calciner in the production of carbon products has been substantiated. Mathematically formulated control task setting includes selected optimality criterion and limitations. Optimality criterion based on the specific operating costs and takes into account costs that depend on technological mode and actual electric calciner performance. The specific operating costs includes material costs of raw materials, energy costs for carbon materials movement in electric calciner and for material heating by Joule heat. Actual electric calciner performance defined as the part of all processed material that has good quality. Limitations consist of material electrical resistivity at the outlet of the apparatus limitation, the temperature of heat treatment limitation, electric 1 канд. техн. наук, доцент, Національний технічний університет України «Київський політехнічнийpower applied to the electrodes limitation and material heat treatment time in electric calciner limitation. Using these limitations when creating control system allows to keep product quality specified value and take into account device design features, carbon material and material heat treatment process in electric calciner features. Control task solving should provide optimally carbon materials heat treatment process functioning in terms of resource and energy saving mode and as a result, improve production of carbon products efficiency in general

Methodology for Development of a 600-Year Tree-Ring Multi-Element Record for Larch from the Taymir Peninsula, Russia

We developed a long (600-year) dataset for the concentrations of 26 elements in tree rings of larch from the Taymir Peninsula, the northernmost region in the world (ca. 72°N) where trees grow. Tree rings corresponding to the time period from 1300 to 1900 A.D. were studied. Eleven wood strips, each from a different larch tree, were cut into ca. 100 mg samples usually consisting of ten consecutive tree rings (but occasionally five). Between 19 and 40 consecutive samples resulted from each tree, yielding a total of 277 samples. The replication of each time interval ranged from three (for periods 1300-1400 A.D. and 1600-1700 A.D.) to six (for 1450-1600 A.D.). Wood samples were digested with concentrated HNO 3 for measurement of Li, B, Na, Mg, Al, Si, P, Cl, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Zr, Nb, Mo, Ag, Cd, Sn, Sb, I, Ba, La, Ce, Nd, W, Au, Pb, Bi, Th, and U using solution Inductively Coupled Plasma Mass Spectrometry (ICPMS). Fourteen elements (V, Co, As, Y, Nb, Mo, Sb, La, Ce, Nd, W, Au, Th, and U) with extremely low concentrations were eliminated from consideration as unreliable. Here we report our sample preparation and measurement procedure, as well as the observed concentrations in tree rings, emphasizing considerations for developing representative and reliable denrodochemical datasets.Нами был получен длительный массив данных (600 лет) концентраций 26 элементов в годичных кольцах лиственницы с полуострова Таймыр, самого северного региона в мире (около 72° с.ш.), где возможен рост деревьев. Изучались годичные кольца, соответствующие промежутку времени с 1300 по 1900 год н.э. Одиннадцать древесных выпилов, по одному для каждой лиственницы, нарезались на образцы массой около 100 мг, которые, как правило, состояли из десяти годичных колец (но в некоторых случаях из пяти). Из каждого дерева было получено от 19 до 40 последовательных образцов, что дало в общей сложности 277 образцов. Повторность для каждого временного интервала варьировала от трех (для периодов 1300-1400 г.н.э. и 1600-1700 г.н.э.) до шести (для периода 1450-1600 г.н.э.). Древесные образцы растворяли в концентрированной HNO 3 для последующего измерения Li, B, Na, Mg, Al, Si, P, Cl, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Zr, Nb, Mo, Ag, Cd, Sn, Sb, I, Ba, La, Ce, Nd, W, Au, Pb, Bi, Th и U при помощи масс-спектрометрии с индуктивно связанной плазмой (ICP-MS) для растворов. Четырнадцать элементов (V, Co, As, Y, Nb, Mo, Sb, La, Ce, Nd, W, Au, Th и U) с очень низкими концентрациями были исключены из рассмотрения как недостоверные. В данной статье, основной целью которой являлась отработка методики получения репрезентативных и достоверных дендрохимических данных, приводится использованная нами процедура пробоподготовки и измерений, а также полученные концентрации в годичных кольцах

Spin Susceptibility in Underdoped YBa2Cu3O6+x\bf YBa_2Cu_3O_{6+x}

We report a comprehensive polarized and unpolarized neutron scattering study of the evolution of the dynamical spin susceptibility with temperature and doping in three underdoped single crystals of the \YBCO{6+x} high temperature superconductor: \YBCO{6.5} (Tc = 52 K), \YBCO{6.7} (Tc = 67 K), and \YBCO{6.85} (T_c = 87 K). Theoretical implications of these data are discussed, and a critique of recent attempts to relate the spin excitations to the thermodynamics of high temperature superconductors is given.Comment: minor revisions, to appear in PR

Two novel missense mutations in the myelin protein zero gene causes Charcot-Marie-Tooth type 2 and Déjérine-Sottas syndrome

<p>Abstract</p> <p>Background</p> <p>The Charcot-Marie-Tooth (CMT) phenotype caused by mutation in the <it>myelin protein zero (MPZ) </it>gene varies considerably, from early onset and severe forms to late onset and milder forms. The mechanism is not well understood. The myelin protein zero (P₀) mediates adhesion in the spiral wraps of the Schwann cell's myelin sheath. The crystalline structure of the extracellular domain of the myelin protein zero (P₀ex) is known, while the transmembrane and intracellular structure is unknown.</p> <p>Findings</p> <p>One novel missense mutation caused a milder late onset CMT type 2, while the second missense mutation caused a severe early onset phenotype compatible with Déjérine-Sottas syndrome.</p> <p>Conclusions</p> <p>The phenotypic variation caused by different missense mutations in the <it>MPZ </it>gene is likely caused by different conformational changes of the MPZ protein which affects the functional tetramers. Severe changes of the MPZ protein cause dysfunctional tetramers and predominantly uncompacted myelin, i.e. the severe phenotypes congenital hypomyelinating neuropathy and Déjérine-Sottas syndrome, while milder changes cause the phenotypes CMT type 1 and 2.</p

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility

BACKGROUND: Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible for a number of neurological disorders. KCNN3 is a neuronal small conductance calcium-activated potassium channel gene that contains two polyglutamine tracts, encoded by polymorphic CAG repeats in the gene. This gene plays a critical role in determining the firing pattern of neurons and acts to regulate intracellular calcium channels. METHODS: The present association study tested whether length variations in the second (more 3') polymorphic CAG repeat in exon 1 of the KCNN3 gene, are involved in susceptibility to migraine with and without aura (MA and MO). In total 423 DNA samples from unrelated individuals, of which 202 consisted of migraine patients and 221 non-migraine controls, were genotyped and analysed using a fluorescence labelled primer set on an ABI310 Genetic Analyzer. Allele frequencies were calculated from observed genotype counts for the KCNN3 polymorphism. Analysis was performed using standard contingency table analysis, incorporating the chi-squared test of independence and CLUMP analysis. RESULTS: Overall, there was no convincing evidence that KCNN3 CAG lengths differ between Caucasian migraineurs and controls, with no significant difference in the allelic length distribution of CAG repeats between the population groups (P = 0.090). Also the MA and MO subtypes did not differ significantly between control allelic distributions (P > 0.05). The prevalence of the long CAG repeat (>19 repeats) did not reach statistical significance in migraineurs (P = 0.15), nor was there a significant difference between the MA and MO subgroups observed compared to controls (P = 0.46 and P = 0.09, respectively), or between MA vs MO (P = 0.40). CONCLUSION: This association study provides no evidence that length variations of the second polyglutamine array in the N-terminus of the KCNN3 channel exert an effect in the pathogenesis of migraine

Genetics of migraine and pharmacogenomics: some considerations

Migraine is a complex disorder caused by a combination of genetic and environmental factors