The article outlines improved methodological approaches to preclinical screening of antihypoxic and cytoprotective drugs. To investigate the effect of Mexidol, carbamylated darbepoetin, darbepoetin, and placebo (isotonic solution for the substance) against the background of hypoxic and cytotoxic effects on cell culture. Get data on the cytoprotective and antihypoxic therapeutic corridor of Mexido