Chronic Stress Facilitates the Development of Deep Venous Thrombosis

The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT. Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans. Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation. The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment. Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats. These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients

Liquid Metal-Based Multifunctional Micropipette for 4D Single Cell Manipulation.

A novel manufacturing approach to fabricate liquid metal-based, multifunctional microcapillary pipettes able to provide electrodes with high electrical conductivity for high-frequency electrical stimulation and measurement is proposed. 4D single cell manipulation is realized by applying multifrequency, multiamplitude, and multiphase electrical signals to the microelectrodes near the pipette tip to create 3D dielectrophoretic trap and 1D electrorotation, simultaneously. Functions such as single cell trapping, patterning, transfer, and rotation are accomplished. Cell viability and multiday proliferation characterization has confirmed the biocompatibility of this approach. This is a simple, low-cost, and fast fabrication process that requires no cleanroom and photolithography step to manufacture 3D microelectrodes and microchannels for easy access to a wide user base for broad applications

SC-TVP Green Practice Initiative in China’s Logistics Market Based on Case Analysis

In the era of circular economy, the concept of sustainable development has attracted more and more attention. With the development of cross-border e-commerce, the demand for logistics services has continued to surge, and the pressure on them to provide sustainable services has risen sharply. In 2020, China officially put forward the “double carbon” strategic goal, and green logistics has become the new direction of industry development, in line with the concept of sustainable development. However, the actual impact of green logistics practice on China’s sustainable logistics services is unknown. This paper aims to study the current situation and results of green logistics practice through data analysis and case analysis, including green design, green transportation, green management and other indicators. Based on the case analysis in this paper, the SC-TVP model is constructed to provide an effective green logistics practice framework, with a view to improving the management level of green logistics, promoting the development of enterprises, and providing some reference for the logistics development in the post-epidemic era

Detecting Political Biases of Named Entities and Hashtags on Twitter

Ideological divisions in the United States have become increasingly prominent in daily communication. Accordingly, there has been much research on political polarization, including many recent efforts that take a computational perspective. By detecting political biases in a corpus of text, one can attempt to describe and discern the polarity of that text. Intuitively, the named entities (i.e., the nouns and phrases that act as nouns) and hashtags in text often carry information about political views. For example, people who use the term "pro-choice" are likely to be liberal, whereas people who use the term "pro-life" are likely to be conservative. In this paper, we seek to reveal political polarities in social-media text data and to quantify these polarities by explicitly assigning a polarity score to entities and hashtags. Although this idea is straightforward, it is difficult to perform such inference in a trustworthy quantitative way. Key challenges include the small number of known labels, the continuous spectrum of political views, and the preservation of both a polarity score and a polarity-neutral semantic meaning in an embedding vector of words. To attempt to overcome these challenges, we propose the Polarity-aware Embedding Multi-task learning (PEM) model. This model consists of (1) a self-supervised context-preservation task, (2) an attention-based tweet-level polarity-inference task, and (3) an adversarial learning task that promotes independence between an embedding's polarity dimension and its semantic dimensions. Our experimental results demonstrate that our PEM model can successfully learn polarity-aware embeddings. We examine a variety of applications and we thereby demonstrate the effectiveness of our PEM model. We also discuss important limitations of our work and stress caution when applying the PEM model to real-world scenarios.Comment: Submitted to EPJ -- Data Science, under revie

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress

Depression is associated with stress-induced neural atrophy in limbic brain regions, whereas exercise has antidepressant effects as well as increasing hippocampal synaptic plasticity by strengthening neurogenesis, metabolism, and vascular function. A key mechanism mediating these broad benefits of exercise on the brain is induction of neurotrophic factors, which instruct downstream structural and functional changes. To systematically evaluate the potential neurotrophic factors that were involved in the antidepressive effects of exercise, in this study, we assessed the effects of swimming exercise on hippocampal mRNA expression of several classes of the growth factors (BDNF, GDNF, NGF, NT-3, FGF2, VEGF, and IGF-1) and peptides (VGF and NPY) in rats exposed to chronic unpredictable mild stress (CUMS). Our study demonstrated that the swimming training paradigm significantly induced the expression of BDNF and BDNF-regulated peptides (VGF and NPY) and restored their stress-induced downregulation. Additionally, the exercise protocol also increased the antiapoptotic Bcl-xl expression and normalized the CUMS mediated induction of proapoptotic Bax mRNA level. Overall, our data suggest that swimming exercise has antidepressant effects, increasing the resistance to the neural damage caused by CUMS, and both BDNF and its downstream neurotrophic peptides may exert a major function in the exercise related adaptive processes to CUMS

Effects of replacement of alfalfa by big-leaf mulberry on growth performance, digestion and meat quality in growing rabbits

[EN] This study aimed to investigate the effect of sundried big-leaf mulberry (BLM) as a replacement for alfalfa on the growth performance, digestibility of nutrients, nitrogen (N) utilisation and meat quality in New Zealand White rabbits. One hundred and sixty weaned rabbits, aged 35±1 d and with a body weight of 755±26 g, were randomly assigned to the 4 treatments with 20 replicates of 2 rabbits (1 male and 1 female) each. Animal performance was evaluated between the 35th and 77th d of age in 40 animals per treatment. The coefficients of total tract apparent digestibility (CTTAD) of nutrients and N utilisation were measured between 77 to 83 d of age in 30 animals per treatment. The control rabbits were fed a corn-soybean meal-alfalfa meal based diet. The three experimental groups were fed a similar diet in which the alfalfa meal was replaced by 10% (BLM10), 20% (BLM20), or 30% (BLM30) BLM. The final body weights and average daily gain were higher (P<0.05) in BLM20 rabbits compared to cThis work was financially supported by the National Natural Science Foundation in Higher Education of Anhui, China (KJ2018A0535), and the fund of Natural Science Foundation of Anhui Province of China (1708085QC74).Wu, XZ.; Yang, PL.; Gao, XH.; Wen, ZG.; Dai, SF.; Zhu, MX.; Wang, LX. (2019). Effects of replacement of alfalfa by big-leaf mulberry on growth performance, digestion and meat quality in growing rabbits. World Rabbit Science. 27(4):199-205. https://doi.org/10.4995/wrs.2019.11529OJS199205274Abu Hafsa S., Salem A., Hassan A., Kholif A., Elghandour M., Barbabosa A., Lopez S. 2016. Digestion, growth performance and caecal fermentation in growing rabbits fed diets containing foliage of browse trees. World Rabbit Sci., 24: 283-293. https://doi.org/10.4995/wrs.2016.4359AOAC International. 2005. Official methods of analysis of the Association of Official Analytical Chemists, 18th ed. Gaithersburg, MD, USA.Blasco A., Ouhayoun J. 1996. Harmonization of criteria and terminology in rabbit meat research. Revised proposal. World Rabbit Sci., 4: 93-99. https://doi.org/10.4995/wrs.1996.278Calvet S., Estellés F., Hermida B., Blumetto O., Torres A.G. 2008. Experimental balance to estimate efficiency in the use of nitrogen in rabbit breeding. World Rabbit Sci., 16: 205-211. https://doi.org/10.4995/wrs.2008.615CIE, 1976. Commission Internationale de l'Eclairage. Official recommendations on uniform colour spaces, colour difference equations and metric colour terms.Dalle Zotte A., Cullere M., Rémignon H., Alberghini L., Paci G. 2016. Meat physical quality and muscle fibre properties of rabbit meat as affected by the sire breed, season, parity order and gender in an organic production system. World Rabbit Sci., 24: 145-154. https://doi.org/10.4995/wrs.2016.4300Deshmukh S.V., Pathak N.N., Takalikar D.A., Digraskar S.U. 1993. Nutritional effect of mulberry ("morus alba") leaves as sole ration of adult rabbits. World Rabbit Sci., 1: 67-69. https://doi.org/10.4995/wrs.1993.196Gidenne T., Combes S., Fortun-Lamothe L. 2013. Protein replacement by digestible fibre in the diet of growing rabbits. 1: Impact on digestive balance, nitrogen excretion and microbial activity. Anim. Feed Sci. Tech., 183: 132-141. https://doi.org/https://doi.org/10.1016/j.anifeedsci.2013.04.022Lounaouci-Ouyed G., Berchiche M., Gidenne T. 2014. Effects of substitution of soybean meal-alfalfa-maize by a combination of field bean or pea with hard wheat bran on digestion and growth performance in rabbits in Algeria. World Rabbit Sci., 22: 137-146. https://doi.org/10.4995/wrs.2014.1487Ma M.R., Liu X.C., Zhu F.H. 2012. Study on biological characteristics and nutritional value of new type forage grass big-leaf mulberry. Acta Agriculturae Jiangxi, 24: 154-155. https://doi.org/10.19386/j.cnki.jxnyxb.2012.07.045Martinez M., Motta W., Cervera C., Pla M. 2005. Feeding mulberry leaves to fattening rabbits: effects on growth, carcass characteristics and meat quality. Animal science (Penicuik, Scotland), 80: 275-281. https://doi.org/10.1079/ASC41110275Mei-Rong M.A., Jin F.H., Dong D., Xiao-Heng W.U., Liu J.X., Polytechnic J. 2014. Effects of Replacing Soybean Meal with Different Levels of Big leaf Mulberry on Growth Performance,Slaughter Performance and Meat Quality in Growing Lambs. Chin. J. Anim. Sci., 50: 40-44. https://doi.org/10.3969/j.issn.0258-7033.2014.07.010Mora-Valverde D. 2010. Consumo de Morera (Morus alba) fresca mezclada con ensilaje de maíz por el ganado Jersey en crecimiento. Agronomía Mesoamericana, 21: 337-341. https://doi.org/10.15517/am.v21i2.4897Nakkitset S., Mikled C., Ledin I. 2008. Effect of Feeding Head Lettuce, Water Spinach, Ruzi grass or Mimosa pigra on Feed Intake, Digestibility and Growth in Rabbits. Asian-Australas J. Anim. Sci., 21: 1171-1177. https://doi.org/10.5713/ajas.2008.70628Ouhayoun J., Dalle Zotte A. 1996. Harmonization of muscle and meat criteria in rabbit meat research. World Rabbit Sci., 4: 211-218. https://doi.org/10.4995/wrs.1996.297Pérez J.M., Lebas F., Gidenne T., Maertens L., Xiccato G., Parigi-Bini R., Dalle Zotte A. 1995. European reference method for in vivo determination of diet digestibility in rabbits. World Rabbit Sci., 3: 41-43. https://doi.org/10.4995/wrs.1995.239Rodriguez M., Carro M.D., Valiente V., Formoso-Rafferty N., Rebollar P.G. 2017. Effects of dietary fish oil supplementation on performance, meat quality, and cecal fermentation of growing rabbits. J. Anim. Sci., 95: 3620-3630. https://doi.org/10.2527/jas.2017.1690Safwat A.M., Sarmiento-Franco L., Santos-Ricalde R.H., Nieves D., Sandoval-Castro C.A. 2015. Estimating Apparent Nutrient Digestibility of Diets Containing Leucaena leucocephala or Moringa oleifera Leaf Meals for Growing Rabbits by Two Methods. Asian-Australas J. Anim. Sci., 28: 1155-1162. https://doi.org/10.5713/ajas.14.0429Shang S.M., Wu Z.Y., Liu G.Y., Sun C.R., Ma M.W., C. Li F. 2017. Effect of substituting Guinea grass with soybean hulls on production performance and digestion traits in fattening rabbits. World Rabbit Sci., 25: 241. https://doi.org/10.4995/wrs.2017.6654Statistical Analysis System. 2009. SAS/STAT User's Guide 9.2,2 ed. Inst. Inc. Cary NC, USA.Tu Y., Diao Q.Y., Zhang R., Yan G.L., Xiong W. 2009. Analysis on feed nutritive value of hybrid Broussonetia papyrifera leaf. Pratacultural Sci., 13: 30-34. https://doi.org/10.1016/0029-8018(90)90025-2Van Soest P.J., Robertson J.B., Lewis B.A. 1991. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J. Dairy Sci., 74: 3583-3597. https://doi.org/10.3168/jds.S0022-0302(91)78551-2Wang Z., He Z., Gan X., Li H. 2018. Interrelationship among ferrous myoglobin, lipid and protein oxidations in rabbit meat during refrigerated and superchilled storage. Meat Sci., 146: 131-139. https://doi.org/10.1016/j.meatsci.2018.08.006Xiccato G., 2010. Fat digestion. In: C. de Blas, Wiseman J. eds. Nutrition of the Rabbit (2nd ed). Wallingford, UK: CAB International, 56-66.Zhang X.F., Huang X., Zheng H.C., Wang Z.G., Jiang Y.Q., Liu J.X. 2015. Effects of Replacing Part of Corn, Bran and Soybean Meal with Different Levels of Fermented Bigleaf Mulberry on Growth and Slaughter Performances in Growth-finishing Pigs. Chin. J. Anim. Sci. https://doi.org/10.3969/j.issn.0258-7033.2015.23.01