1,183 research outputs found

    Message Passing-Based Joint User Activity Detection and Channel Estimation for Temporally-Correlated Massive Access

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    This paper studies the user activity detection and channel estimation problem in a temporally-correlated massive access system where a very large number of users communicate with a base station sporadically and each user once activated can transmit with a large probability over multiple consecutive frames. We formulate the problem as a dynamic compressed sensing (DCS) problem to exploit both the sparsity and the temporal correlation of user activity. By leveraging the hybrid generalized approximate message passing (HyGAMP) framework, we design a computationally efficient algorithm, HyGAMP-DCS, to solve this problem. In contrast to only exploit the historical estimations, the proposed algorithm performs bidirectional message passing between the neighboring frames for activity likelihood update to fully exploit the temporally-correlated user activities. Furthermore, we develop an expectation maximization HyGAMP-DCS (EM-HyGAMP-DCS) algorithm to adaptively learn the hyperparameters during the estimation procedure when the system statistics are unknown. In particular, we propose to utilize the analysis tool of state evolution to find the appropriate hyperparameter initialization of EM-HyGAMP-DCS. Simulation results demonstrate that our proposed algorithms can significantly improve the user activity detection accuracy and reduce the channel estimation error.Comment: 31 pages, 14 figures, minor revisio

    An Empirical Study of Technology Diffusion and International Trade in korea: Using patent Application Data

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    International trade is an important conduit for international technology diffusion. Considering the endogenous growth theory, a rapid increase of foreign patent application, and international trade in Korea, it seems meaningful to study the role of international trade in the technology diffusion from foreign countries to Korea. This paper investigates the relationship between the trade and technology diffusion by using Korean patent data and trade data. We found that the international trade of Korea with foreign countries was very significant variable

    Cooperative Multi-Cell Massive Access with Temporally Correlated Activity

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    This paper investigates the problem of activity detection and channel estimation in cooperative multi-cell massive access systems with temporally correlated activity, where all access points (APs) are connected to a central unit via fronthaul links. We propose to perform user-centric AP cooperation for computation burden alleviation and introduce a generalized sliding-window detection strategy for fully exploiting the temporal correlation in activity. By establishing the probabilistic model associated with the factor graph representation, we propose a scalable Dynamic Compressed Sensing-based Multiple Measurement Vector Generalized Approximate Message Passing (DCS-MMV-GAMP) algorithm from the perspective of Bayesian inference. Therein, the activity likelihood is refined by performing standard message passing among the activities in the spatial-temporal domain and GAMP is employed for efficient channel estimation. Furthermore, we develop two schemes of quantize-and-forward (QF) and detect-and-forward (DF) based on DCS-MMV-GAMP for the finite-fronthaul-capacity scenario, which are extensively evaluated under various system limits. Numerical results verify the significant superiority of the proposed approach over the benchmarks. Moreover, it is revealed that QF can usually realize superior performance when the antenna number is small, whereas DF shifts to be preferable with limited fronthaul capacity if the large-scale antenna arrays are equipped.Comment: 16 pages, 17 figures, minor revisio

    Development of an indirect enzyme-linked immunosorbent assay (ELISA) assay based on a recombinant truncated VP2 (tVP2) protein for the detection of canine parvovirus antibodies

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    By removing the N-terminal hydrophobic sequence, truncated VP2 (tVP2) genes were cloned into the pET-32a (+) plasmid and subsequently expressed as His fusion proteins. The purified recombinant tVP2 proteins were specific to canine parvovirus (CPV), and one of them was used in an indirect enzyme-linked immunosorbent assay (ELISA) for the detection of CPV antibodies. The minimum detection limit of this method was 1:1280. There was good agreement between tVP2-based indirect ELISA and the commercially available diagnostic kit. The results suggest that the recombinant tVP2 protein-based ELISA could be used to detect CPV antibodies.Key words: Canine parvovirus, recombinant truncated VP2 (tVP2), enzyme-linked immunosorbent assay (ELISA), antibody detection

    Positive selection on hemagglutinin and neuraminidase genes of H1N1 influenza viruses

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    BACKGROUND: Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 influenza viruses from different hosts. RESULTS: Phylogenetic analysis revealed that both HA and NA genes have evolved into five distinct clusters, with further analyses indicating that the pandemic 2009 strains have experienced the strongest positive selection. We also found evidence of strong selection acting on the seasonal human H1N1 isolates. However, swine viruses from North America and Eurasia were under weak positive selection, while there was no significant evidence of positive selection acting on the avian isolates. A site-by-site analysis revealed that the positively selected sites were located in both of the cleaved products of HA (HA1 and HA2), as well as NA. In addition, the pandemic 2009 strains were subject to differential selection pressures compared to seasonal human, North American swine and Eurasian swine H1N1 viruses. CONCLUSIONS: Most of these positively and/or differentially selected sites were situated in the B-cell and/or T-cell antigenic regions, suggesting that selection at these sites might be responsible for the antigenic variation of the viruses. Moreover, some sites were also associated with glycosylation and receptor-binding ability. Thus, selection at these positions might have helped the pandemic 2009 H1N1 viruses to adapt to the new hosts after they were introduced from pigs to humans. Positive selection on position 274 of NA protein, associated with drug resistance, might account for the prevalence of drug-resistant variants of seasonal human H1N1 influenza viruses, but there was no evidence that positive selection was responsible for the spread of the drug resistance of the pandemic H1N1 strains
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