Numerical Modeling of Debris Flows Induced by Dam-Break Using the Smoothed Particle Hydrodynamics (SPH) Method

Dam-break flows may change into debris flows if certain conditions are satisfied, such as abundant loose material and steep slope. These debris flows are typically characterized by high density and can generate strong impact forces. Due to the complexity of the materials that they are made of, it has always been very challenging to numerically simulate these phenomena and accurately reproduce experimentally debris flows’ processes. Therefore, to fill this gap, the formation-movement processes of debris flows induced by dam-break were simulated numerically, modifying the existing smoothed particle hydrodynamics (SPH) method. By comparing the shape and the velocity of dam break debris flows under different configurations, it was found that when simulating the initiation process, the number of particles in the upstream section is overestimated while the number of particles in the downstream area is underestimated. Furthermore, the formation process of dam-break debris flow was simulated by three models which consider different combinations of the viscous force, the drag force and the virtual mass force. The method taking into account all these three kinds of interface forces produced the most accurate outcome for the numerical simulation of the formation process of dam-break debris flow. Finally, it was found that under different interface force models, the particle velocity distribution did not change significantly. However, the direction of the particle force changed, which is due to the fact that the SPH model considers generalized virtual mass forces, better replicating real case scenarios. The modalities of dam failures have significant impacts on the formation and development of debris flows. Therefore, the results of this study will help authorities to select safe sites for future rehabilitation and relocation projects and can also be used as an important basis for debris flow risk management. Future research will be necessary to understand more complex scenarios to investigate mechanisms of domino dam-failures and their effects on debris flows propagation

The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp

<p>Abstract</p> <p>Background</p> <p>The heme acquisition machinery in <it>Streptococcus pyogenes </it>is believed to consist of the surface proteins, Shr and Shp, and heme-specific ATP-binding cassette transporter HtsABC. Shp has been shown to rapidly transfer its heme to the lipoprotein component, HtsA, of HtsABC. The function of Shr and the heme source of Shp have not been established.</p> <p>Results</p> <p>The objective of this study was to determine whether Shr binds heme and is a heme source of Shp. To achieve the objective, recombinant Shr protein was prepared. The purified Shr displays a spectrum typical of hemoproteins, indicating that Shr binds heme and acquires heme from <it>Escherichia coli </it>hemoproteins in vivo. Spectral analysis of Shr and Shp isolated from a mixture of Shr and heme-free Shp (apoShp) indicates that Shr and apoShp lost and gained heme, respectively; whereas Shr did not efficiently lose its heme in incubation with apoHtsA under the identical conditions. These results suggest that Shr directly transfers its heme to Shp. In addition, the rates of heme transfer from human hemoglobin to apoShp are close to those of simple ferric heme dissociation from hemoglobin, suggesting that methemoglobin does not directly transfer its heme to apoShp.</p> <p>Conclusion</p> <p>We have demonstrated that recombinant Shr can acquire heme from <it>E. coli </it>hemoproteins in vivo and appears to directly transfer its heme to Shp and that Shp appears not to directly acquire heme from human methemoglobin. These results suggest the possibility that Shr is a source of heme for Shp and that the Shr-to-Shp heme transfer is a step of the heme acquisition process in <it>S. pyogenes</it>. Further characterization of the Shr/Shp/HtsA system would advance our understanding of the mechanism of heme acquisition in <it>S. pyogenes</it>.</p

Style Generation: Image Synthesis based on Coarsely Matched Texts

Previous text-to-image synthesis algorithms typically use explicit textual instructions to generate/manipulate images accurately, but they have difficulty adapting to guidance in the form of coarsely matched texts. In this work, we attempt to stylize an input image using such coarsely matched text as guidance. To tackle this new problem, we introduce a novel task called text-based style generation and propose a two-stage generative adversarial network: the first stage generates the overall image style with a sentence feature, and the second stage refines the generated style with a synthetic feature, which is produced by a multi-modality style synthesis module. We re-filter one existing dataset and collect a new dataset for the task. Extensive experiments and ablation studies are conducted to validate our framework. The practical potential of our work is demonstrated by various applications such as text-image alignment and story visualization. Our datasets are published at https://www.kaggle.com/datasets/mengyaocui/style-generation

Pulsar discovery prospect of FASTA

The Five-hundred-meter Aperture Spherical radio Telescope (FAST) has discovered more than 650 new pulsars, which account for 20% of our known Galactic pulsar population. In this paper, we estimate the prospect of a pulsar survey with a radio telescope array to be planned -- the FAST Array (FASTA), consists of six "FAST-type" telescopes. Such a sensitive radio telescope array would be a powerful instrument in probing the pulsar population deep into our Galaxy as well as in nearby galaxies. We simulate the FASTA pulsar discovery prospects with different Galactic pulsar population models and instrumental parameter combinations. We find that FASTA could detect tens of thousands of canonical pulsars and well-over thousands of millisecond pulsars. We also estimate the potential yield if the FASTA is used to search for pulsars from the nearby spiral galaxy M31, and find that it would probably discover around a hundred new radio pulsars

Lake volume variation in the endorheic basin of the Tibetan Plateau from 1989 to 2019

Lake storage change serves as a unique indicator of natural climate change on the Tibetan Plateau (TP). However, comprehensive lake storage data, especially for lakes smaller than 10 km2, are still lacking in the region. In this dataset, we completed a census of annual relative lake volume (RLV) for 976 lakes, which are larger than 1 km2, on the endorheic basin of the Tibetan Plateau (EBTP) during 1989–2019 using Landsat imagery and digital terrain models. Our method first identifies individual lakes, determines their analysis extents and calculates annual lake area from Landsat imagery. It then derives lake area-elevation relationship, estimates lake surface elevation, and calculates RLV. Validation and comparison with several existing datasets indicate our data are more reliable and comprehensive. Our study complements existing lake datasets by providing a complete and long-term lake water volume change data for the region

空間的分布情報を利用した多変量自己回帰状態空間(MARSS)モデルによる東シナ海の漁業資源評価

学位の種別: 課程博士審査委員会委員 : （主査）東京大学准教授 山川 卓, 東京大学教授 白木原 國雄, 東京大学准教授 平松 一彦, 東京大学元教授 大竹 二雄, 横浜商科大学教授 小松 輝久University of Tokyo(東京大学

The Two-Component Regulatory System VicRK is Important to Virulence of Streptococcus equi Subspecies equi

This study aims at evaluating the importance of the two-component regulatory system VicRK to virulence of the horse pathogen Streptococcus equi subspecies equi and the potential of a vicK mutant as a live vaccine candidate using mouse infection models. The vicK gene was deleted by gene replacement. The ΔvicK mutant is attenuated in virulence in both subcutaneous and intranasal infections in mice. ΔvicK grows less slowly than the parent strain but retains the ability of S. equi to resist to phagocytosis by polymorphoneuclear leukocytes, suggesting that the vicK deletion causes growth defect. ΔvicK infection protects mice against reinfection with a wild-type S. equi strain. Intranasal ΔvicK infection induces production of anti-SeM mucosal IgA and systemic IgG. These results indicate that VicRK is important to S. equi growth and virulence and suggest that ΔvicK has the potential to be developed as a live S. equi vaccine