3D Modeling and Inversion of Gravity Data in Exploration Scale

The gravity method has been widely used for detecting the subsurface density anomaly and geological structures. The interpretation result based on gravity data can be used for mineral/oil exploration and regional geological study. The effective and successful application of gravity methods depends on the fast forward modeling and stable inversion tools to image the subsurface density structures. In this chapter, we will review the applications and developments of gravity method. We starts form the basic theory for gravity field and the scalar gravity potential and introduce the closed form of the solution for the gravity field caused by a density anomaly. Different gravity data forward modeling and inversion techniques will be introduced in this chapter with their application in petroleum reconnaissance. Several examples will be presented in this chapter to illustrate the application of different gravity modeling and inversion techniques

Effectiveness and safety of co-administration of moxifloxacin with netilmicin in drug-resistant tuberculosis patients, and its impact on inflammatory factors and immune function

Purpose: To study the effectiveness and safety of co-administration of moxifloxacin with netilmicin in drug-resistant tuberculosis (TB) patients, and its impact on levels of inflammatory factors and immune function. Methods: We enrolled 100 patients with drug-resistant TB admitted to People’s Hospital of Rizhao between May 2017 and October 2019. The patients were randomly allocated to control group and study group, with 50 patients per group. The control group received moxifloxacin at a dose of 0.2 g t.i.d. for 6 months and the study group received netilmicin at a dose of 0.1 g t.i.d. plus. The response, incidence of adverse reactions, expression levels of inflammatory factors, immune function, and sputum-negative status after 2, 4 and 6 months of TB treatment were compared. Results: The study group showed markedly higher response than the control group (p < 0.05). Moreover, there were lower incidence of adverse effects in the study group than in the control group (p < 0.05). The expression levels of inflammatory factors were significantly lower in the study group, while the concentrations of CD3+, CD4+, and CD8+ were markedly higher (p < 0.05). After 2, 4 and 6 months of TB treatment, cases of sputum-negative conversion were significantly higher in the study group than in the control group (p < 0.05). Conclusion: Co-administration of moxifloxacin with netilmicin produces much higher effectiveness and safety than moxifloxacin monotherapy, decreases inflammatory factor levels and improves immune function in patients with drug-resistant TB

The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

<p>Abstract</p> <p>Background</p> <p>This paper investigates the effects of a new radiosensitizer, doranidazole, and enhancing irradiation on colorectal cancer cells.</p> <p>Methods</p> <p>The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high doses of γ-ray irradiation under hypoxic conditions <it>in vitro</it>. Fluorescence staining and cell migration assays were also used to assess the radiosensitizing effect.</p> <p>Results</p> <p>Cell proliferation evaluated by clonogenic survival curves was significantly inhibited by 5 mmol/L doranidazole, particularly at doses ranging from 10 to 30 Gy of irradiation. The radiosensitizing effect of doranidazole on colorectal cancer cells occurs in a time- and dose-dependent manner. Doranidazole also inhibited the mobility of cell invasion and migration.</p> <p>Conclusion</p> <p>Doranidazole can enhance the killing effect and the cell growth inhibition of colorectal cancer after high-dose irradiation in a time and dose-dependent manner.</p

A Double-Boost Converter Based on Coupled Inductance and Magnetic Integration

High-voltage gain converter has a high-frequency use in some industrial fields, for instance, the fuel cell system, the photovoltaic system, electric vehicles, and the high-intensity discharge lamp. In order to solve the problem of the low-voltage gain of traditional boost converter, the double-boost converter with coupled inductance and doubled voltage is proposed, which connects the traditional boost converter in parallel. The voltage gain of the converter is further improved by introducing the voltage-doubled unit of the coupled inductance. Moreover, the clamp capacitor can absorb the leakage inductance in the circuit and reduce the voltage stress of the switch. In addition, two coupled inductors are magnetically collected; then, the loss of the core is analyzed under the same gain. The detailed analysis of the proposed converter and a comparison considering other topologies previously published in the literature are also presented in this article. In order to verify the proposed converter performance, a prototype has been built for a power of 200 W, input and output voltages of 12 and 84 V, respectively, and a switching frequency of 50 kHz. Experimental results validate the effectiveness of the theoretical analysis proving the satisfactory converter performance, whose peak efficiency is 95.5%

S gene mutations of HBV in children with HBV-associated glomerulonephritis

<p>Abstract</p> <p>Background</p> <p>Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a kind of immune complex-induced glomerulonephritis. The present study was designed to determine whether mutation of Hepatitis B virus (HBV) S gene is associated with glomerulonephritis in Chinese children.</p> <p>Methods</p> <p>Total 53 subjects, including 30 HBV-GN, 5 nephrosis with HBV carriers (control group 1), and 18 HBV carriers (control group 2) were included in this study. Polymerase chain reaction (PCR) was used to detect the HBV-GN S gene mutation.</p> <p>Results</p> <p>(1) The serotype of HBV was adw in the majority (52/53) of subjects, and was adr in only 1 subject in the control group 2; (2) the genotype of HBV was the type B in 51 subjects, the type E in 1 HBV-GN child, and the type C in 1 HBV carrier; (3) Seventeen point mutations in the S gene of HBV were identified in 21 of 30 (70%) HBV-GN patients. Among them, 16 of 21 (76.2%) mutations may cause amino acid substitutions of the HBV proteins, which occur predominantly (11/16 mutations) at threonine, serine or tyrosine phosphorylation sites of mitogen-activated protein kinase (MAPK) or protein tyrosine kinase (PTK). (4) In addition, single nucleotide mutations without amino acid substitutions (same sense mutation) were found in 2 subjects in each control group and 5 subjects in HBV-GN group.</p> <p>Conclusions</p> <p>HBV S gene mutations and the subsequent amino acid substitutions in HBV proteins were found in most children with HBV-GN, suggesting that these mutations may play an important role in the pathogenesis of HBV-GN.</p

A review on smart strategies for active layer phase separation regulation of organic solar cells

Exciton dissociation and charge transport are important processes in the photoelectric conversion of organic solar cells (OSCs), directly affecting the performance of OSCs. In order to facilitate exciton dissociation, phase separation size should be as small as possible. However, for the sake of continuous charge transport, a large phase separation size is also necessary. To balance these two conflicting needs, it is of utmost importance to regulate the phase separation of the active layer. This Review mainly elaborated the smart tactics commonly adopted to phase separation optimization, aiming to understand how these treatments affect both the active layer phase separation and the performance of OSCs. Furthermore, we present an outlook on the new opportunities of phase separation regulation of the active layer. Finally, this Review may provide some reference for the researchers engaged in the research of OSCs

Cell survival curve of Colo 201 after different doses of irradiation under hypoxia in the presence or absence of 5 mmol/L Doranidazole

<p><b>Copyright information:</b></p><p>Taken from "The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation"</p><p>http://www.biomedcentral.com/1471-2407/7/188</p><p>BMC Cancer 2007;7():188-188.</p><p>Published online 6 Oct 2007</p><p>PMCID:PMC2082041.</p><p></p

Cell growth and cell death of Colo 201 exposed to Doranidazole for 4 days

<p><b>Copyright information:</b></p><p>Taken from "The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation"</p><p>http://www.biomedcentral.com/1471-2407/7/188</p><p>BMC Cancer 2007;7():188-188.</p><p>Published online 6 Oct 2007</p><p>PMCID:PMC2082041.</p><p></p