The evaluation of experimental data in fast range for n + 56

Iron is one of the five materials selected for evaluation within the pilot international evaluation project CIELO. Analysis of experimental data for n+56Fe reaction is the basis for constraining theoretical calculations and eventual creation of the evaluated file. The detail analysis was performed for inelastic cross sections of neutron induced reactions with 56Fe in the fast range up to 20 MeV where there are significant differences among the main evaluated libraries, mainly caused by the different inelastic scattering cross section measurements. Gamma-ray production cross sections provide a way to gain experimental information about the inelastic cross section. Large discrepancies between experimental data for the 847-keV gamma ray produced in the 56Fe(n,n1'γ) reaction were analyzed. In addition, experimental data for elastic scattering cross section between 9.41∼11 MeV were used to deduce the inelastic cross section from the unitarity constrain

Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (<i>Sargentodoxa cuneata</i> (Oliv.) Rehd. et W and <i>Alangium chinense</i> (Lour.) Harms) by UPLC-MS/MS

Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia. At the same time, the combination of Sargentodoxa cuneata (Oliv.) Rehd. et W (SC) and Alangium chinense (Lour.) Harms (AC), the core drug pair (CDP) in the formula of JGL, is used at high frequencies in many Miao medicine prescriptions for rheumatic diseases. However, previous research lacks the pharmacokinetic study of JGL, and study on the compatibility of its CDP with other medicinal herbs in the formula is needed. This study aims to establish a simple, rapid, and sensitive Ultra Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) method for the simultaneous determination of four main bioactive components of JGL in rat plasma, including Salidroside (Sal), Anabasine (Ana), Chlorogenic Acid (CA), and Protocatechuic Acid (PCA), and compare the pharmacokinetic properties of two groups of rats after being orally administrated with JGL and its CDP extracts, respectively. The results showed that area under the plasma concentration-time curve (AUC), mean retention time (MRT), and clearance rate (CL), of Sal, Ana, CA and PCA in the two groups of rats were changed in different degrees. The CDP combined with other drugs could significantly increase the absorption of Sal and Ana, prolong its retention time in vivo, and may accelerate the absorption rate of CA and PCA. This indicated that the combination of CDP and other herbs may affect the pharmacokinetics process of active components in vivo, increase the exposure and bioavailability of compounds in the JGL group, and prolong the retention time, which may be the reason why JGL has a better inhibitory effect on inflammatory cytokines, providing a viable orientation for the compatibility investigation of herb medicines

Effect of Ti6Al4V reinforcement particles on the mechanical, wear, and corrosion properties of AZ91D magnesium matrix composites

This study aims to synthesize composite materials using TC4 particles and AZ91D alloy through semi-solid stirring and hot extrusion techniques. The main objective is to investigate the microstructure, mechanical properties, wear resistance, and corrosion behavior of composites comprising a minor volume fraction (0, 2, and 5 vol%) of spherical TC4 particles. The findings showed that the dual synergistic effect of TC4 particles and the β-phase leads to a refinement in the grain size of the composite material. Moreover, the incorporation of TC4 particles enhances the hardness, yield strength (YS), and ultimate tensile strength (UTS) of the magnesium matrix, with almost no reduction observed in ductility. Additionally, the TC4/AZ91D composite displays lower wear rates and friction coefficients compared to the matrix when subjected to forces of 150 N and 300 N. However, the corrosion performance of the composite material deteriorates due to the influence of the galvanic effect between the particles and the matrix

Anti-Rheumatoid Arthritis Pharmacodynamic Substances Screening of <i>Periploca forrestii</i> Schltr.: Component Analyses In Vitro and In Vivo Combined with Multi-Technical Metabolomics

The purpose of this study was to elucidate the metabolic action patterns of P. forrestii against rheumatoid arthritis (RA) using metabolomics, and to obtain its potential effective substances for treating RA. First, the therapeutic effects of P. forrestii against RA were confirmed; second, the chemical composition of P. forrestii was analyzed, and 17 prototypes were absorbed into blood; subsequently, plasma metabolomics studies using UPLC-Triple-TOF-MS/MS and GC-MS were performed to disclose the metabolomics alterations in groups, which revealed 38 altered metabolites after drug intervention. These metabolites were all associated with the arthritis pathophysiology process (−log(p) > 1.6). Among them, sorted by variable important in projection (VIP), the metabolites affected (VIP ≥ 1.72) belonged to lipid metabolites. Finally, Pearson’s analysis between endogenous metabolites and exogenous compounds was conducted to obtain potential pharmacological substances for the P. forrestii treatment of RA, which showed a high correlation between five blood-absorbed components and P. forrestii-regulated metabolites. This information provides a basis for the selection of metabolic action modes for P. forrestii clinical application dosage, and potential pharmacological substances that exerted anti-RA effects of P. forrestii were discovered. The study provided an experimental basis for further research on pharmacoequivalence, molecular mechanism validation, and even the development of new dosage forms in the future

The evaluation of experimental data in fast range for n + 56Fe(n,inl)

Iron is one of the five materials selected for evaluation within the pilot international evaluation project CIELO. Analysis of experimental data for n+56Fe reaction is the basis for constraining theoretical calculations and eventual creation of the evaluated file. The detail analysis was performed for inelastic cross sections of neutron induced reactions with 56Fe in the fast range up to 20 MeV where there are significant differences among the main evaluated libraries, mainly caused by the different inelastic scattering cross section measurements. Gamma-ray production cross sections provide a way to gain experimental information about the inelastic cross section. Large discrepancies between experimental data for the 847-keV gamma ray produced in the 56Fe(n,n1'γ) reaction were analyzed. In addition, experimental data for elastic scattering cross section between 9.41∼11 MeV were used to deduce the inelastic cross section from the unitarity constrain