Two-parameter asymptotic expansions for elliptic equations with small geometric perturbation and high contrast ratio

We consider the asymptotic solutions of an interface problem corresponding to an elliptic partial differential equation with Dirich- let boundary condition and transmission condition, subject to the small geometric perturbation and the high contrast ratio of the conductivity. We consider two types of perturbations: the first corresponds to a thin layer coating a fixed bounded domain and the second is the per perturbation of the interface. As the perturbation size tends to zero and the ratio of the conductivities in two subdomains tends to zero, the two-parameter asymptotic expansions on the fixed reference domain are derived to any order after the single parameter expansions are solved be- forehand. Our main tool is the asymptotic analysis based on the Taylor expansions for the properly extended solutions on fixed domains. The Neumann boundary condition and Robin boundary condition arise in two-parameter expansions, depending on the relation of the geometric perturbation size and the contrast ratio

Modeling and Control of Networked Systems with Different Loop Topologies

AbstractIn this paper, modeling and control of networked control system with different loop topology structures are considered. The indeterminate time-delay is known to the controller node by using time-stamping and introducing buffers for different topology structure NCSs. The uniform discrete state-space model is established by introducing state augmentation for both short and long time-delay. Then, the controller is designed by augmented state pole-placement algorithm

Floroindole confers protection against cecal ligation and puncture-induced sepsis via inhibition of NF-kB p65 phosphorylation

Purpose: To investigate the protective effect of floroindole against cecal ligation and puncture (CLP)- induced sepsis, as well as the underlying mechanism of action. Methods: Thirty-five 10–week-old male Wistar rats weighing 190 - 210 g (mean: 200.00 ± 10.10 g) were used for this study. The rats were randomly assigned to seven groups of five rats each, viz, normal control group, and six CLP groups. The CLP groups were those subjected to cecal ligation and puncture (CLP). The first 5 CLP groups received 2, 4, 6, 8 or 10 mg/kg floroindole, respectively, 1 h after CLP, via intraperitoneal route (i.p.) while the 6th CLP group served as untreated control. Western blotting, enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) were used for the assessment of the expression levels of tumor necrosis factor-α (TNF- α), interleukn-6 (IL-6), nucleotide-binding oligomerization domain 2 (NOD2) and p-NF-κB p65. Results: Cecal ligation and puncture (CLP) significantly and time-dependently upregulated the expressions of TNF-α, IL-6 and NOD2 in intestinal tissues of rats (p < 0.05). However, treatment with floroindole significantly, and dose-dependently down-regulated CLP-induced expressions of these proteins (p < 0.05). Treatment of rats with floroindole also significantly and dose-dependently inhibited CLP-induced phosphorylation of NF-κB p65 in rat ileum (p < 0.05). Conclusion: The results obtained in this study demonstrate that floroindole confers some degree of protection against CLP-induced sepsis via inhibition of NF-κB p65 phosphorylation

Molecular Detection of Porcine Torovirus in Piglets with Diarrhea in Southwest China

Porcine torovirus (PToV) was detected from intestinal samples of piglets with diarrhea from 20 farms in southwest China. The total prevalence of PToV was 45% (9 out of 20 farms); it was the first detection of PToV in China, and also the study analyzed the phylogenetic relationships between the Chinese PToV and PToV reference strains as well as other representative toroviruses. Genetic and phylogenetic analysis showed the existence of genetic diversity among geographically separated PToV. Statistical analysis of the PToV positive rate as well as a survey for other enteric pathogens in diarrheic pigs suggests that PToV may play a role as a causative agent of severe diarrhea in piglets