The Gentlest Ascent Dynamics

Dynamical systems that describe the escape from the basins of attraction of stable invariant sets are presented and analyzed. It is shown that the stable fixed points of such dynamical systems are the index-1 saddle points. Generalizations to high index saddle points are discussed. Both gradient and non-gradient systems are considered. Preliminary results on the nature of the dynamical behavior are presented

HST and LAMOST discover a dual active galactic nucleus in J0038+4128

We report the discovery of a kiloparsec-scale dual active galactic nucleus (AGN) in J0038+4128. From the Hubble Space Telescope (HST) Wide Field Planetary Camera (WFPC2) images, we find two optical nuclei with a projection separation of 4.7 kpc (3.44 arcsec). The southern component (J0038+4128S) is spectroscopically observed with the HST Goddard High Resolution Spectrograph in the UV range and is found to be a Seyfert 1 galaxy with a broad Ly alpha emission line. The northern component (J0038+4128N) is spectroscopically observed during the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (also named the Guoshoujing Telescope) pilot survey in the optical range. The observed line ratios as well as the consistency of redshift of the nucleus emission lines and the host galaxy's absorption lines indicate that J0038+4128N is a Seyfert 2 galaxy with narrow lines only. These results thus confirm that J0038+4128 is a Seyfert 1-Seyfert 2 AGN pair. The HST WFPC2 F336W/U-band image of J0038+4128 also reveals for the first time for a dual AGN system two pairs of bi-symmetric arms, as are expected from the numerical simulations of such system. Being one of a few confirmed kiloparsec-scale dual AGNs exhibiting a clear morphological structure of the host galaxies, J0038+4128 provides an unique opportunity to study the co-evolution of the host galaxies and their central supermassive black holes undergoing a merging process.Comment: 6 pages, 4 figures, 2 tables, Accepted for publication in MNRAS Letter

TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer.

TIFA (TNF receptor associated factor (TRAF)-interacting protein with a Forkhead-associated (FHA) domain), also called T2BP, was first identified using a yeast two-hybrid screening. TIFA contains a FHA domain, which directly binds phosphothreonine and phosphoserine, and a consensus TRAF6-binding motif. TIFA-mediated oligomerization and poly-ubiquitinylation of TRAF6 mediates signaling downstream of the Tumor necrosis factor alpha receptor 1 (TNFaR-I) and interleukin-1/Toll-like receptor 4 (TLR4) pathways. Examining TIFA expression in hepatocellular carcinoma (HCC) tissues microarrays, we noted marked decreases TIFA reactivity in tumor versus control samples. In agreement, we found that HCC cell lines show reduced TIFA expression levels versus normal liver controls. Reconstituting TIFA expression in HCC cell lines promoted two independent apoptosis signaling pathways: the induction of p53 and cell cycle arrest, and the activation of caspase-8 and caspase-3. In contrast, the expression of a non-oligomerizing mutant of TIFA impacted cells minimally, and suppression of TIFA expression protected cells from apoptosis. Mice bearing TIFA overexpression hepatocellular xenografts develop smaller tumors versus TIFA mutant tumors; terminal deoxynucleotidyl transferase dUTP nick end labeling staining demonstrates increased cell apoptosis, and decreased proliferation, reflecting cell cycle arrest. Interestingly, p53 has a greater role in decreased proliferation than cell death, as it appeared dispensable for TIFA-induced cell killing. The findings demonstrate a novel suppressive role of TIFA in HCC progression via promotion of cell death independent of p53

Coexistence of multi-photon processes and longitudinal couplings in superconducting flux qubits

In contrast to natural atoms, the potential energies for superconducting flux qubit (SFQ) circuits can be artificially controlled. When the inversion symmetry of the potential energy is broken, we find that the multi-photon processes can coexist in the multi-level SFQ circuits. Moreover, there are not only transverse but also longitudinal couplings between the external magnetic fields and the SFQs when the inversion symmetry of potential energy is broken. The longitudinal coupling would induce some new phenomena in the SFQs. Here we will show how the longitudinal coupling can result in the coexistence of multi-photon processes in a two-level system formed by a SFQ circuit. We also show that the SFQs can become transparent to the transverse coupling fields when the longitudinal coupling fields satisfy the certain conditions. We further show that the quantum Zeno effect can also be induced by the longitudinal coupling in the SFQs. Finally we clarify why the longitudinal coupling can induce coexistence and disappearance of single- and two-photon processes for a driven SFQ, which is coupled to a single-mode quantized field.Comment: 11 pages, 6 figure

A convenient tandem one-pot synthesis of donor-acceptor-type triphenylene 2,3-dicarboxylic esters from diarylacetylene

A tandem one-pot method for the direct synthesis of polysubstituted triphenylene 2,3-dicarboxylic esters with different substitution patterns was developed by enyne metathesis of diarylacetylene, followed by Diels–Alder, aromatization and a cyclization cascade

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

The ‘ribosomal stress (RS)-p53 pathway’ is triggered by any stressor or genetic alteration that disrupts ribosomal biogenesis, and mediated by several ribosomal proteins (RPs), such as RPL11 and RPL5, which inhibit MDM2 and activate p53. Inosine monophosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate-limiting enzyme in de novo guanine nucleotide biosynthesis and crucial for maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It is highly expressed in many malignancies. We previously showed that inhibition of IMPDH2 leads to p53 activation by causing RS. Surprisingly, our current study reveals that Inauzhin (INZ), a novel non-genotoxic p53 activator by inhibiting SIRT1, can also inhibit cellular IMPDH2 activity, and reduce the levels of cellular GTP and GTP-binding nucleostemin that is essential for rRNA processing. Consequently, INZ induces RS and the RPL11/RPL5-MDM2 interaction, activating p53. These results support the new notion that INZ suppresses cancer cell growth by dually targeting SIRT1 and IMPDH2

Physical accessible transformations on a finite number of quantum states

We consider to treat the usual probabilistic cloning, state separation, unambiguous state discrimination, \emph{etc} in a uniform framework. All these transformations can be regarded as special examples of generalized completely positive trace non-increasing maps on a finite number of input states. From the system-ancilla model we construct the corresponding unitary implementation of pure $\to$ pure, pure $\to$ mixed, mixed $\to$ pure, and mixed $\to$ mixed states transformations in the whole system and obtain the necessary and sufficient conditions on the existence of the desired maps. We expect our work will be helpful to explore what we can do on a finite set of input states.Comment: 7 page

Relation between hyperbolic Nizhnik-Novikov-Veselov equation and stationary Davey-Stewartson II equation

A Lax system in three variables is presented, two equations of which form the Lax pair of the stationary Davey-Stewartson II equation. With certain nonlinear constraints, the full integrability condition of this Lax system contains the hyperbolic Nizhnik-Novikov-Veselov equation and its standard Lax pair. The Darboux transformation for the Davey-Stewartson II equation is used to solve the hyperbolic Nizhnik-Novikov-Veselov equation. Using Darboux transformation, global $n$-soliton solutions are obtained. It is proved that each $n$-soliton solution approaches zero uniformly and exponentially at spatial infinity and is asymptotic to $n^2$ lumps of peaks at temporal infinity.Comment: 25 pages, 5 figure