IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells.

The neurotropic JHM strain of mouse hepatitis virus (JHMV) replicates primarily within glial cells following intracranial inoculation of susceptible mice, with relative sparing of neurons. This study demonstrates that glial cells derived from neural progenitor cells are susceptible to JHMV infection and that treatment of infected cells with IFN-gamma inhibits viral replication in a dose-dependent manner. Although type I IFN production is muted in JHMV-infected glial cultures, IFN-beta is produced following IFN-gamma-treatment of JHMV-infected cells. Also, direct treatment of infected glial cultures with recombinant mouse IFN-alpha or IFN-beta inhibits viral replication. IFN-gamma-mediated control of JHMV replication is dampened in glial cultures derived from the neural progenitor cells of type I receptor knock-out mice. These data indicate that JHMV is capable of infecting glial cells generated from neural progenitor cells and that IFN-gamma-mediated control of viral replication is dependent, in part, on type I IFN secretion

Network analysis of the worldwide footballer transfer market

The transfer of football players is an important part in football games. Most studies on the transfer of football players focus on the transfer system and transfer fees but not on the transfer behavior itself. Based on the 470,792 transfer records from 1990 to 2016 among 23,605 football clubs in 206 countries and regions, we construct a directed footballer transfer network (FTN), where the nodes are the football clubs and the links correspond to the footballer transfers. A systemic analysis is conduced on the topological properties of the FTN. We find that the in-degrees, out-degrees, in-strengths and out-strengths of nodes follow bimodal distributions (a power law with exponential decay), while the distribution of link weights has a power-law tail. We further figure out the correlations between node degrees, node strengths and link weights. We also investigate the general characteristics of different measures of network centrality. Our network analysis of the global footballer transfer market sheds new lights into the investigation of the characteristics of transfer activities.Comment: 7 pages, 6 figure

The H-index of a network node and its relation to degree and coreness

Identifying influential nodes in dynamical processes is crucial in understanding network structure and function. Degree, H-index and coreness are widely used metrics, but previously treated as unrelated. Here we show their relation by constructing an operator , in terms of which degree, H-index and coreness are the initial, intermediate and steady states of the sequences, respectively. We obtain a family of H-indices that can be used to measure a node’s importance. We also prove that the convergence to coreness can be guaranteed even under an asynchronous updating process, allowing a decentralized local method of calculating a node’s coreness in large-scale evolving networks. Numerical analyses of the susceptible-infected-removed spreading dynamics on disparate real networks suggest that the H-index is a good tradeoff that in many cases can better quantify node influence than either degree or coreness.This work was partially supported by the National Natural Science Foundation of China (Grant Nos. 11205042, 11222543, 11075031, 61433014). L.L. acknowledges the research start-up fund of Hangzhou Normal University under Grant No. PE13002004039 and the EU FP7 Grant 611272 (project GROWTHCOM). The Boston University work was supported by NSF Grants CMMI 1125290, CHE 1213217 and PHY 1505000. (11205042 - National Natural Science Foundation of China; 11222543 - National Natural Science Foundation of China; 11075031 - National Natural Science Foundation of China; 61433014 - National Natural Science Foundation of China; PE13002004039 - research start-up fund of Hangzhou Normal University; 611272 - EU FP7 Grant (project GROWTHCOM); CMMI 1125290 - NSF; CHE 1213217 - NSF; PHY 1505000 - NSF)Published versio

Community analysis of global financial markets

We analyze the daily returns of stock market indices and currencies of 56 countries over the period of 2002–2012. We build a network model consisting of two layers, one being the stock market indices and the other the foreign exchange markets. Synchronous and lagged correlations are used as measures of connectivity and causality among different parts of the global economic system for two different time intervals: non-crisis (2002–2006) and crisis (2007–2012) periods. We study community formations within the network to understand the influences and vulnerabilities of specific countries or groups of countries. We observe different behavior of the cross correlations and communities for crisis vs. non-crisis periods. For example, the overall correlation of stock markets increases during crisis while the overall correlation in the foreign exchange market and the correlation between stock and foreign exchange markets decrease, which leads to different community structures. We observe that the euro, while being central during the relatively calm period, loses its dominant role during crisis. Furthermore we discover that the troubled Eurozone countries, Portugal, Italy, Greece and Spain, form their own cluster during the crisis period.Published versio