445 research outputs found
Effect of vehicle-track vertical coupling vibrations on frame-mounted traction motor dynamics
In order to reveal the effect of the vehicle-track vertical coupling vibrations on the frame-mounted traction motor dynamics, a vehicle-track vertical coupling dynamic model with considering the influence of the frame-mounted traction motor is established, and the correctness of the model is verified by real vehicle test. In case of the investigated vehicle model, the influences of the vehicle-track vertical coupling vibrations and the suspension parameters on the frame-mounted traction motor dynamics are discussed. The results show that the traction motor is significantly affected by the train system, when the motor is equivalent to the bogie frame mass, the phenomenon of underestimation exists to evaluate the vibration of the motor. In addition, suspension parameters have a great impact on the traction motor dynamics, rational selection suspension parameters can help to attenuate the vibration of the traction motor, and alleviate uneven the distribution of the air gap magnetic field of the traction motor
Ultimate boundary estimations and topological horseshoe analysis of a new 4D hyper-chaotic system
In this paper, we first estimate the boundedness of a new proposed 4-dimensional (4D) hyper-chaotic system with complex dynamical behaviors. For this system, the ultimate bound set Ω1 and globally exponentially attractive set Ω2 are derived based on the optimization method, Lyapunov stability theory and comparison principle. Numerical simulations are presented to show the effectiveness of the method and the boundary regions. Then, to prove the existence of hyper-chaos, the hyper-chaotic dynamics of the 4D nonlinear system is investigated by means of topological horseshoe theory and numerical computation. Based on the algorithm for finding horseshoes in three-dimensional hyper-chaotic maps, we finally find a horseshoe with two-directional expansions in the 4D hyper-chaotic system, which can rigorously prove the existence of the hyper-chaos in theory
Aggregation of TDP-43 fragments triggers cellular aberrant function: implication in neurodegeneration
Vibration characteristics of the impeller at multi-conditions in mixed-flow pump under the action of fluid-structure interaction
In this study, the flow field and impeller structure response in the mixed-flow pump are cooperative solved based on the bidirectional synchronization solving method, to study the vibration characteristics of the mixed-flow pump impeller rotor under the fluid-structure interaction. The pressure distributions of blade surface in the mixed-flow pump under different flow rate conditions were compared, and the deformation, equivalent stress distribution and natural vibration frequency of impeller blade under static force load were studied. Meanwhile, the deformation of impeller blade and coupling stress distribution was analyzed based on bidirectional fluid-structure interaction. The results show that the deformation of impeller blade increases from hub to rim, and the maximum deformation occurs at the rim of the blade. The stress distribution of impeller blade in the circumferential direction is symmetrical, and the maximum equivalent stress occurs at the blade outlet edge near the hub. The maximum deformation position and the stress concentration location are basically consistent before and after coupling calculation, but the maximum deformation value increases and the maximum equivalent stress value decreases under the fluid-structure interaction. The influence of water pressure on the strength and frequency of vibration is very limited. With the increase of flow rate, the maximum equivalent stress of impeller decreases and the total deformation increases gradually. The results of this research provide reference basis for the structure design and reliability analysis of the mixed-flow pump
A Galactomannoglucan Derived from Agaricus brasiliensis: Purification, Characterization and Macrophage Activation via MAPK and IkappaB/NFkappaB Pathways
In this study, a novel galactomannoglucan named as TJ2 was isolated from Agaricus brasiliensis with microwave extraction, macroporous resin, ion exchange resin and high resolution gel chromatography. TJ2 is composed of glucose, mannose and galactose in the ratio 99.2:0.2:0.6. Infrared spectra (IR), methylation analysis and nuclear magnetic resonance spectra indicated that TJ2 mainly contained a b-(1?3) – linked glucopyranosyl backbone. Interestingly, TJ2 significantly promoted RAW264.7 cell proliferation, and was able to activate the cells to engulf E. coli. In addition, TJ2 induced the expression of Interleukin 1b (IL-1b), Interleukin 6 (IL-6), tumor necrosis factor a (TNF-a) and cyclooxygenase-2 (Cox-2) in the cells. TJ2 also promoted the production of nitric oxide (NO) by inducing the expression of inducible nitric oxide synthase (iNOS). Moreover, TJ2 is a potent inducer in activating the mitogen-activated protein kinase (MAPK) and inhibitor of nuclear factor-kappa B (IkappaB)/nuclear factor-kappa B (NFkappaB) pathways
Dynamic modeling, simulation and experimental investigation on cycling-trainers equipped with suspensions considering human biomechanical characteristics
At present, to meet the innervation and the comfort of cycling-trainers, the trend of deploying suspension system is still upwards. However, there is no reliable dynamic model for cycling-trainers equipped with suspension systems, and the influence of the suspension damping on the dynamic responses needs to be explored. In this paper, based on a commercially available cycling-trainer with suspension systems, a non-linear dynamic model of trainer-human coupled system was established. According to the bench test, the damping coefficient of suspension dampers was measured. By the cycling test, the dynamic model was validated. The test values of the vertical acceleration of the human lower trunk are in agreement with the simulation values, in which the maximum deviation is less than 15.0Â % and the root mean square deviation is less than 8.0Â %. Based on the model, the influences of the damper damping on the dynamic responses were analyzed. The results show that the influence laws of the suspension damping characteristics on the human body responses vary greatly under the different riding frequencies, and an optimal damping exists to avoid excessive fatigue caused by vibration under the medium and low frequency riding conditions. The established model and the revealed rules can provide useful reference for the suspension design and optimization of cycling-trainers
Exploratory Factor Analysis for Validating Traditional Chinese Syndrome Patterns of Chronic Atrophic Gastritis
Background. Traditional Chinese medicine (TCM) has long been used to treat chronic atrophic gastritis (CAG). The aim of the present study was to evaluate the TCM syndrome characteristics of CAG and its core pathogenesis so as to promote optimization of treatment strategies. Methods. This study was based on a participant survey conducted in 4 hospitals in China. Patients diagnosed with CAG were recruited by simple random sampling. Exploratory factor analysis (EFA) was conducted on syndrome extraction. Results. Common factors extracted were assigned to six syndrome patterns: qi deficiency, qi stagnation, blood stasis, phlegm turbidity, heat, and yang deficiency. Distribution frequency of all syndrome patterns showed that qi deficiency, qi stagnation, blood stasis, phlegm turbidity, and heat excess were higher (76.7%–84.2%) compared with yang deficiency (42.5%). Distribution of main syndrome patterns showed that frequencies of qi deficiency, qi stagnation, phlegm turbidity, heat, and yang deficiency were higher (15.8%–20.8%) compared with blood stasis (8.3%). Conclusions. The core pathogenesis of CAG is combination of qi deficiency, qi stagnation, blood stasis, phlegm turbidity, heat, and yang deficiency. Therefore, treatment strategy of herbal prescriptions for CAG should include herbs that regulate qi, activate blood, resolve turbidity, clear heat, remove toxin, and warm yang
Numerical Prediction and Performance Experiment in an Engine Cooling Water Pump with Different Blade Outlet Widths
Moderate increase of precipitation stimulates CO2 production by regulating soil organic carbon in a saltmarsh
Saltmarsh is widely recognized as a blue carbon ecosystem with great carbon storage potential. Yet soil respiration with a major contributor of atmospheric CO2 can offset its carbon sink function. Up to date, mechanisms ruling CO2 emissions from saltmarsh soil remain unclear. In particular, the effect of precipitation on soil CO2 emissions is unclear in coastal wetlands, due the lack of outdoor data in real situations. We conducted a 7-year field manipulation experiment in a saltmarsh in the Yellow River Delta, China. Soil respiration in five treatments (−60%, −40%, +0%, +40%, and + 60% of precipitation) was measured in the field. Topsoils from the last 3 years (2019–2021) were analyzed for CO2 production potential by microcosm experiments. Furthermore, quality and quantity of soil organic carbon and microbial function were tested. Results show that only the moderate precipitation rise of +40% induced a 66.2% increase of CO2 production potential for the microcosm experiments, whereas other data showed a weak impact. Consistently, soil respiration was also found to be strongest at +40%. The CO2 production potential is positively correlated with soil organic carbon, including carbon quantity and quality. But microbial diversity did not show any positive response to precipitation sizes. r-/K-strategy seemed to be a plausible explanation for biological factors. Overall, our finding reveal that a moderate precipitation increase, not decrease or a robust increase, in a saltmarsh is likely to improve soil organic carbon quality and quantity, and bacterial oligotroph:copiotroph ratio, ultimately leading to an enhanced CO2 production
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