24,127 research outputs found
Practical Block-wise Neural Network Architecture Generation
Convolutional neural networks have gained a remarkable success in computer
vision. However, most usable network architectures are hand-crafted and usually
require expertise and elaborate design. In this paper, we provide a block-wise
network generation pipeline called BlockQNN which automatically builds
high-performance networks using the Q-Learning paradigm with epsilon-greedy
exploration strategy. The optimal network block is constructed by the learning
agent which is trained sequentially to choose component layers. We stack the
block to construct the whole auto-generated network. To accelerate the
generation process, we also propose a distributed asynchronous framework and an
early stop strategy. The block-wise generation brings unique advantages: (1) it
performs competitive results in comparison to the hand-crafted state-of-the-art
networks on image classification, additionally, the best network generated by
BlockQNN achieves 3.54% top-1 error rate on CIFAR-10 which beats all existing
auto-generate networks. (2) in the meanwhile, it offers tremendous reduction of
the search space in designing networks which only spends 3 days with 32 GPUs,
and (3) moreover, it has strong generalizability that the network built on
CIFAR also performs well on a larger-scale ImageNet dataset.Comment: Accepted to CVPR 201
Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells
Following a synthetic chemistry blueprint for the valorization of lignocellulosic platform chemicals, this study showcases a so far unprecedented approach to implement non-natural enzyme modules in vivo. For the design of a novel functional whole cell tool, two purely abiotic transformations, a styrene monooxygenase-catalyzed Achmatowicz rearrangement and an alcohol dehydrogenase-mediated borrowing hydrogen redox isomerization, were incorporated into a recombinant bacterial host. Introducing this type of chemistry otherwise unknown in biosynthesis, the cellular factories were enabled to produce complex lactone building blocks in good yield from bio-based furan substrates. This whole cell system streamlined the synthetic cascade, eliminated isolation and purification steps, and provided a high degree of stereoselectivity that has so far been elusive in the chemical methodology.Peer reviewe
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