156 research outputs found
Down-Regulation of Fructose-1, 6-Bisphosphatase-1 (FBP1) in High Grade Urothelial Carcinoma (UC); as a New Diagnostic Marker to Differentiate Nested Variants of Urothelial Carcinoma from Benign Entities
A Numerical Analysis Research on Earlier Behavior of Molten Droplet Covered with Vapor Film at the Stage of Triggering and Propagation in Steam Explosion
When the molten fuel with high temperature falls into the cavity water, it will be dispersed into droplets which are covered with vapor films due to the rapid heat transfer with phase transition. This situation cannot be simply described by liquid-liquid or gas-liquid systems. And there are no sufficient experimental studies on the behavior of droplet covered with vapor film because of the rapid reaction and the difficulty in capture of the film configuration. In this paper, a multiphase code with the volume of fluid (VOF) method is used to simulate the earlier behavior of droplet when vapor film exits. The earlier behavior is defined as behavior of the droplet before its disintegration. Thermal effect and pure hydrodynamic effect are, respectively, considered. The simulation results indicate that the film thickness and material density have significant effect on the earlier behavior of droplet. The situation assumed in Ciccarelli and Frost’s model (1994) is observed in current simulation of earlier thermal droplet behavior. The effect of triggering pressure pulse on earlier hydrodynamic behavior is also discussed and it indicates that vapor film has little effect on the hydrodynamic droplet deformation when the intensity of the pressure pulse is very high
Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit
Achieving spatiotemporal control of light at high-speeds presents immense
possibilities for various applications in communication, computation,
metrology, and sensing. The integration of subwavelength metasurfaces and
optical waveguides offers a promising approach to manipulate light across
multiple degrees of freedom at high-speed in compact photonic integrated
circuit (PICs) devices. Here, we demonstrate a gigahertz-rate-switchable
wavefront shaping by integrating metasurface, lithium niobite on insulator
(LNOI) photonic waveguide and electrodes within a PIC device. As proofs of
concept, we showcase the generation of a focus beam with reconfigurable
arbitrary polarizations, switchable focusing with lateral focal positions and
focal length, orbital angular momentum light beams (OAMs) as well as Bessel
beams. Our measurements indicate modulation speeds of up to gigahertz rate.
This integrated platform offers a versatile and efficient means of controlling
light field at high-speed within a compact system, paving the way for potential
applications in optical communication, computation, sensing, and imaging
16S rRNA gene sequencing reveals the correlation between the gut microbiota and the susceptibility to pathological scars
The gut microbiome profile in patients with pathological scars remains rarely known, especially those patients who are susceptible to pathological scars. Previous studies demonstrated that gut microbial dysbiosis can promote the development of a series of diseases via the interaction between gut microbiota and host. The current study aimed to explore the gut microbiota of patients who are prone to suffer from pathological scars. 35 patients with pathological scars (PS group) and 40 patients with normal scars (NS group) were recruited for collection of fecal samples to sequence the 16S ribosomal RNA (16S rRNA) V3-V4 region of gut microbiota. Alpha diversity of gut microbiota showed a significant difference between NS group and PS group, and beta diversity indicated that the composition of gut microbiota in NS and PS participants was different, which implied that dysbiosis exhibits in patients who are susceptible to pathological scars. Based on phylum, genus, species levels, we demonstrated that the changing in some gut microbiota (Firmicutes; Bacteroides; Escherichia coli, etc.) may contribute to the occurrence or development of pathological scars. Moreover, the interaction network of gut microbiota in NS and PS group clearly revealed the different interaction model of each group. Our study has preliminary confirmed that dysbiosis exhibits in patients who are susceptible to pathological scars, and provide a new insight regarding the role of the gut microbiome in PS development and progression
Potential of Core-Collapse Supernova Neutrino Detection at JUNO
JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve
Detection of the Diffuse Supernova Neutrino Background with JUNO
As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO
Real-time Monitoring for the Next Core-Collapse Supernova in JUNO
Core-collapse supernova (CCSN) is one of the most energetic astrophysical
events in the Universe. The early and prompt detection of neutrinos before
(pre-SN) and during the SN burst is a unique opportunity to realize the
multi-messenger observation of the CCSN events. In this work, we describe the
monitoring concept and present the sensitivity of the system to the pre-SN and
SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is
a 20 kton liquid scintillator detector under construction in South China. The
real-time monitoring system is designed with both the prompt monitors on the
electronic board and online monitors at the data acquisition stage, in order to
ensure both the alert speed and alert coverage of progenitor stars. By assuming
a false alert rate of 1 per year, this monitoring system can be sensitive to
the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos
up to about 370 (360) kpc for a progenitor mass of 30 for the case
of normal (inverted) mass ordering. The pointing ability of the CCSN is
evaluated by using the accumulated event anisotropy of the inverse beta decay
interactions from pre-SN or SN neutrinos, which, along with the early alert,
can play important roles for the followup multi-messenger observations of the
next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure
Numerical simulation of thermochemical non-equilibrium flow-field characteristics around a hypersonic atmospheric reentry vehicle
A multi-physics thermochemical non-equilibrium model is established to study the flow characteristics of the plasma sheath around an atmospheric reentry demonstrator. This model includes the tight coupling of Navier-Stokes equations, 54 chemical reactions of air, and a four-temperature model. The processes of dissociation, ionization, and the internal energy exchanges of air components were successfully simulated during aerodynamic heating of the reentry vehicle. The distributions of plasma sheath temperature, the molar fraction of air species, stagnation pressure, surface pressure, and electron number density around the reentry vehicle were obtained at different flight altitudes. Additionally, to validate the numerical model developed in this study, the flow characteristics of the Radio Attenuation Measurement-C-II (RAM-C-II) vehicle are also simulated and then compared with corresponding experimental data. They show good consistency in general. It is found that when the vehicle is at a high flight altitude, there is a strong thermochemical non-equilibrium phenomenon around the vehicle. However, the plasma sheath tends to be in local thermal equilibrium at a low flight altitude. The distance from the shock layer to the stagnation point decreases with a decrease in reentry altitude from 90 to 65 km but increases with a decrease from 65 to 40 km. The electron number density in the shock layer is maximum. The distribution of the electron number density in the wake region differs significantly at different flight altitudes
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