Bis[1,3-bis­(diphenyl­phosphinoylimino)isoindolinato-κ3 O,N,O′]calcium(II)

In the title compound, [Ca(C32H24N3O2P2)2], the 1,3-bis­(diphenyl­phosphinoylimino)isoindoline ligand adopts a tridentate coordination mode. The compound exhibits a distorted octa­hedral geometry. The Ca atom lies on a twofold rotation axis

Commodifying Non-English Foreign Language via Chinese University Websites

This paper examines the commodification of non-English foreign languages through the official websites of 42 China’s double first-class universities. Informed by the concepts of language as commodity (Heller 2010), this study examines how non-English foreign languages are ideologically constructed as valued resources exchange for decent job, advanced education and China’s regional integration. However, the study also finds that even these websites try their best to portray non-English foreign languages as valuable commodity, the concept of English as the default language still permeates in the whole promoting process. Therefore, there is still some tensions between ideal promoting vision and actual practices. This study can shed lights on the valorization of multilingual education in China and the promotion of non-English foreign languages to the world

An Analysis of the Construction and Development of ‘Starry Star’ Training Camp in Zhengzhou City

Since 2017, the Ministry of Education has taken the lead in establishing the \u27Starry Star\u27 pilot training camp. As a leading city of school football campaign/activity, Zhengzhou City takes up heavy responsibility of continuously promoting the rapid development of school football in Henan Province. This paper adopts such methodologies such as literature, fieldwork, mathematical statistics and logical analysis to identify the weaknesses in the current phase of construction and to make reasonable recommendations according to policies and the actual situation for pointing out the direction for the future development. In terms of organizational leadership, all relevant policies and documents are well-developed reflecting the high degree of importance attached to each training camp, but very few of them have omissions in the development of the system of admissions and training management regulations. In terms of condition guarantee, three aspects are prominent, including the treatment of coaches (calculation of hours), the size of the training grounds at each training site not meeting the requirements of the camps\u27 participation groups (due to limited size of the campus), and the lack of implementation of supporting funds (in the surrounding counties). In terms of competition and training, all schools lost points to varying degrees in the various detailed assessment indicators of the survey and assessment such as inappropriate teaching attitude of the teaching staff, unsystematic training syllabus, unfinished work arrangements for two tournaments and one practice and insufficient attention to the campers\u27 performance in cultural subjects. In terms of reserve training and training participation rate, nearly 30% of the camps failed to send outstanding athletes to higher level schools; half of the camps failed to ensure over 90% attendance of campers. It is suggested that relevant authorities should in future give standardized and clear policies regarding admissions and other related systems. Further, the authorities should clarify the way of coaches\u27 salary and title appraisal, focus on the implementation of matching funds for training camps, and gradually adjust the correspondence between matching camper groups and camp site conditions. As the main task of the Starry Star training camps, more attention should be placed in future work, improving policies, seriously correcting and dealing with various situations that affect the quality of race training in each camp. The authorities should optimize the way of supplying outstanding athletes, and at the same time strengthen regular inspections and random checks for the attendance, putting equal emphasis on training quality and participation

Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification.

Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice. However, essential ingredients in TCM herbs have not been fully identified, and their precise mechanisms and targets are not elucidated. In this study, a new strategy combining comprehensive two-dimensional K562/cell membrane chromatographic system and in silico target identification was established to characterize active components from Indigo naturalis, a famous TCM herb that has been widely used for the treatment of leukemia in China, and their targets. Three active components, indirubin, tryptanthrin and isorhamnetin, were successfully characterized and their anti-leukemia effects were validated by cell viability and cell apoptosis assays. Isorhamnetin, with undefined cancer related targets, was selected for in silico target identification. Proto-oncogene tyrosine-protein kinase (Src) was identified as its membrane target and the dissociation constant (Kd) between Src and isorhamnetin was 3.81 μM. Furthermore, anti-leukemia effects of isorhamnetin were mediated by Src through inducing G2/M cell cycle arrest. The results demonstrated that the integrated strategy could efficiently characterize active components in TCM and their targets, which may bring a new light for a better understanding of the complex mechanism of herbal medicines

Molecular cloning and functional characterization of BcTSA in the biosynthesis of indole alkaloids in Baphicacanthus cusia

Baphicacanthus cusia (Nees) Bremek (B. cusia) is an essential traditional Chinese herb that is commonly used to treat colds, fever, and influenza. Indole alkaloids, such as indigo and indirubin, are the primary active constituents of B. cusia. The indole-producing reaction is crucial for regulating the flow of indole alkaloids metabolites along the pathways and coordinating primary and secondary product biosynthesis in plants. The tryptophan synthase alpha-subunit (TSA) can catalyse a process that produces indole, which is free to enter secondary metabolite pathways; however, the underlying potential mechanism of regulating indigo alkaloids synthesis remains unknown. Here, a BcTSA was cloned from the transcriptome of B. cusia. The BcTSA has a significant degree of similarity with other plant TSAs according to bioinformatics and phylogenetic analyses. Quantitative real-time PCR (RT-qPCR) research showed that BcTSA was dramatically enhanced in response to treatment with methyl jasmonate (MeJA), salicylic acid (SA), and abscisic acid (ABA), and was predominantly expressed in the stems as opposed to the leaves and rhizomes. Subcellular localization revealed that BcTSA is localized in chloroplasts, which is compatible with the fact that the conversion of indole-3-glycerol phosphate (IGP) to indole occurs in chloroplasts. The complementation assay results showed that BcTSA was functional, demonstrating that it was capable of catalyzing the conversion of IGP to indole. BcTSA was shown to stimulate the manufacture of indigo alkaloids including isatin, indigo, and indirubin when the gene was overexpressed in the hairy roots of Isatis indigotica. In conclusion, our research provides novel perspectives that might be applied to manipulating the indole alkaloid composition of B. cusia

Urinary biomarkers associated with podocyte injury in lupus nephritis

The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular epithelial cell damage. Assays for urine biomarkers have demonstrated significant promise in the early detection of LN, evaluation of disease activity, and tracking of reaction to therapy. This is because they are non-invasive, allow for frequent monitoring and easy self-collection, transport and storage. Podocyte injury is believed to be a essential factor in LN. The extent and type of podocyte injury could be connected to the severity of proteinuria, making podocyte-derived cellular debris and injury-related urinary proteins potential markers for the diagnosis and monitoring of LN. This article focuses on studies examining urinary biomarkers associated with podocyte injury in LN, offering fresh perspectives on the application of biomarkers in the early detection and management of LN

Mechanical Properties of Recycled Concrete in Marine Environment

Experimental work was carried out to develop information about mechanical properties of recycled concrete (RC) in marine environment. By using the seawater and dry-wet circulation to simulate the marine environment, specimens of RC were tested with different replacement percentages of 0%, 30%, and 60% after immersing in seawater for 4, 8, 12, and 16 months, respectively. Based on the analysis of the stress-strain curves (SSCs) and compressive strength, it is revealed that RC’ peak value and elastic modulus decreased with the increase of replacement percentage and corroding time in marine environment. And the failure of recycled concrete was speeded up with more obvious cracks and larger angles of 65° to 85° in the surface when compared with normal concrete. Finally, the grey model (GM) with equal time intervals was constructed to investigate the law of compressive strength of recycled concrete in marine environment, and it is found that the GM is accurate and feasible for the prediction of RC compressive strength in marine environment