Effect of earthquake on stability of subway station and ground motions of surrounding rock masses

The effect of earthquakes on the stability of the subway station and ground motions of surrounding rock masses, plays a key role in the seismic design of the subway station to avoid severe damage to subway station itself and adjacent structures. Most of the reported cases in the literatures on the effect of earthquake on ground motions focused on the ground motions without considering underground structures. In this study, the effect of earthquakes on the stability of the subway station, and ground motions of surrounding rock masses were investigated by using the Flac3d. The ground acceleration and safety factor of tunnel lining were highlighted. The results of the numerical analysis indicated the presence of a subway station has a great influence on ground motions, especially for the vertical ground acceleration. The ground acceleration increases with the decrease of buried depth. The amplification factor of ground acceleration is about 1.42. It exists an amplification region above the subway station with the width of 15 m. The safety factor of tunnel lining in subway station has a significant decrease in the maximum decrease rate of 67 %. The safety factor of tunnel lining except for tunnel crown and bottom changes periodic. Ground acceleration will induce extrusion or detach between surrounding rock masses and tunnel lining, and the direction of ground acceleration has a great influence on distribution of safety factor. The side wall and arch feet of tunnel lining is the most unfavorable part. Special attention should be paid to the side wall and arch feet of the subway station during seismic design

Effect of earthquake on stability of subway station and ground motions of surrounding rock masses

The effect of earthquakes on the stability of the subway station and ground motions of surrounding rock masses, plays a key role in the seismic design of the subway station to avoid severe damage to subway station itself and adjacent structures. Most of the reported cases in the literatures on the effect of earthquake on ground motions focused on the ground motions without considering underground structures. In this study, the effect of earthquakes on the stability of the subway station, and ground motions of surrounding rock masses were investigated by using the Flac3d. The ground acceleration and safety factor of tunnel lining were highlighted. The results of the numerical analysis indicated the presence of a subway station has a great influence on ground motions, especially for the vertical ground acceleration. The ground acceleration increases with the decrease of buried depth. The amplification factor of ground acceleration is about 1.42. It exists an amplification region above the subway station with the width of 15 m. The safety factor of tunnel lining in subway station has a significant decrease in the maximum decrease rate of 67 %. The safety factor of tunnel lining except for tunnel crown and bottom changes periodic. Ground acceleration will induce extrusion or detach between surrounding rock masses and tunnel lining, and the direction of ground acceleration has a great influence on distribution of safety factor. The side wall and arch feet of tunnel lining is the most unfavorable part. Special attention should be paid to the side wall and arch feet of the subway station during seismic design

Effect of earthquake on stability of subway station and ground motions of surrounding rock masses

The effect of earthquakes on the stability of the subway station and ground motions of surrounding rock masses, plays a key role in the seismic design of the subway station to avoid severe damage to subway station itself and adjacent structures. Most of the reported cases in the literatures on the effect of earthquake on ground motions focused on the ground motions without considering underground structures. In this study, the effect of earthquakes on the stability of the subway station, and ground motions of surrounding rock masses were investigated by using the Flac3d. The ground acceleration and safety factor of tunnel lining were highlighted. The results of the numerical analysis indicated the presence of a subway station has a great influence on ground motions, especially for the vertical ground acceleration. The ground acceleration increases with the decrease of buried depth. The amplification factor of ground acceleration is about 1.42. It exists an amplification region above the subway station with the width of 15 m. The safety factor of tunnel lining in subway station has a significant decrease in the maximum decrease rate of 67 %. The safety factor of tunnel lining except for tunnel crown and bottom changes periodic. Ground acceleration will induce extrusion or detach between surrounding rock masses and tunnel lining, and the direction of ground acceleration has a great influence on distribution of safety factor. The side wall and arch feet of tunnel lining is the most unfavorable part. Special attention should be paid to the side wall and arch feet of the subway station during seismic design

Burden of carbon monoxide poisoning in China, 1990–2019: A systematic analysis of data from the global burden of disease study 2019

BackgroundCarbon monoxide (CO) poisoning is one of the most common toxic occupational diseases, but related data in China are scarce. A better understanding of the burden of CO poisoning is essential for improving its management.MethodsA systematic analysis of data from the Global Burden of Disease (GBD) Study 2019 was conducted. Following the general analytical strategy used in the GBD Study 2019, the sex- and age-specific incidence and mortality rates of CO poisoning and disability-adjusted life years (DALYs) due to CO poisoning in China were analyzed. Estimated average annual percentage changes (AAPCs) in age-standardized rates were calculated by joinpoint regression analysis. The effects of age, period and cohort on the incidence of CO poisoning and DALYs due to CO poisoning were estimated by an age-period-cohort model.ResultsThe age-standardized incidence and mortality rates as well as DALYs of CO poisoning per 100,000 population were estimated to be 21.82 [95% uncertainty interval (UI): 15.05–29.98], 0.93 (95% UI: 0.63–1.11), and 40.92 (95% UI: 28.43–47.85), respectively, in 2019. From 1990 to 2019, the AAPCs in the age-standardized incidence significantly increased in both males and females, while the age-standardized mortality rates and DALYs significantly decreased in both males and females. The incidence of CO poisoning peaked in individuals aged 15–19 years. Males had a higher burden of CO poisoning than females. The age effect showed that the relative risks (RRs) of incident CO poisoning decreased with age among males and females and that individuals aged 15–24 years had the highest RRs. The RRs of incident CO poisoning increased with time. The cohort effect showed that the incidence increased in successive birth cohorts.ConclusionsThe incidence of CO poisoning in China increased from 1990 to 2019. More attention should be given to improving the burden of CO poisoning in Chinese adolescents. The results of this study can be used by health authorities to inform preventative measures to reduce the burden of CO poisoning

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies

Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma

XGNN: Towards Model-Level Explanations of Graph Neural Networks

Graphs neural networks (GNNs) learn node features by aggregating and combining neighbor information, which have achieved promising performance on many graph tasks. However, GNNs are mostly treated as black-boxes and lack human intelligible explanations. Thus, they cannot be fully trusted and used in certain application domains if GNN models cannot be explained. In this work, we propose a novel approach, known as XGNN, to interpret GNNs at the model-level. Our approach can provide high-level insights and generic understanding of how GNNs work. In particular, we propose to explain GNNs by training a graph generator so that the generated graph patterns maximize a certain prediction of the model.We formulate the graph generation as a reinforcement learning task, where for each step, the graph generator predicts how to add an edge into the current graph. The graph generator is trained via a policy gradient method based on information from the trained GNNs. In addition, we incorporate several graph rules to encourage the generated graphs to be valid. Experimental results on both synthetic and real-world datasets show that our proposed methods help understand and verify the trained GNNs. Furthermore, our experimental results indicate that the generated graphs can provide guidance on how to improve the trained GNNs

Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein

A new homozygous humanized transgenic mouse strain, HLA-A2.1+/+HLA-DP4+/+ hCD4+/+mCD4−/−IAβ−/−β2m−/− (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2+/+β2m−/− (A2) mouse and our previously created HLA-DP4+/+ hCD4+/+mCD4−/−IAβ−/− (DP4) mouse. We confirmed that the transgenes (HLA-A2, HLA-DP4, hCD4) inherited from the parental A2 and DP4 mice are functional in the HLA-A2/DP4 mice. After immunizing HLA-A2/DP4 mice with a hepatitis B DNA vaccine, hepatitis B virus-specific antibodies, HLA-A2-restricted and HLA-DP4-restricted responses were observed to be similar to those in naturally infected humans. Therefore, the present study demonstrated that HLA-A2/DP4 transgenic mice can faithfully mimic human cellular responses. Furthermore, we reported four new HLA-DP4-restricted epitopes derived from HBsAg that were identified in both vaccinated HLA-A2/DP4 mice and HLA-DP4-positive human individuals. The HLA-A2/DP4 mouse model is a promising preclinical animal model carrying alleles present to more than a quarter of the human population. This model should facilitate the identification of novel HLA-A2- and HLA-DP4-restricted epitopes and vaccine development as well as the characterization of HLA-DP4-restricted responses against infection in humans

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701