90 research outputs found
Impact of diagenesis on the pore evolution and sealing capacity of carbonate cap rocks in the Tarim Basin, China
Analyzing the pore structure and sealing efficiency of carbonate cap rocks is essential to assess their ability to retain hydrocarbons in reservoirs and minimize leaking risks. In this contribution, the impact of diagenesis on the cap rocks' sealing capacity is studied in terms of their pore structure by analyzing rock samples from Ordovician carbonate reservoirs (Tarim Basin). Four lithology types are recognized: highly compacted, peloidal packstone-grainstone; highly cemented, intraclastic-oolitic-bioclastic grainstone; peloidal dolomitic limestone; and incipiently dolomitized, peloidal packstone-grainstone. The pore types of cap rocks include microfractures, intercrystalline pores, intergranular pores, and dissolution vugs. The pore structure of these cap rocks was heterogeneously modified by six diagenetic processes, including calcite cementation, dissolution, mechanical and chemical compaction, dolomitization, and calcitization (dedolomitization). Three situations affect the rocks' sealing capacity: (1) grainstone cap rocks present high sealing capacity in cases where compaction preceded cementation; (2) residual microfractures connecting adjacent pores result in low sealing capacity; and (3) increasing grain size in grainstones results in a larger proportion of intergranular pores being cemented. Four classes of cap rocks have been defined according to the lithology, pore structures, diagenetic alterations, and sealing performance. Class I cap rocks present the best sealing capacity because they underwent intense mechanical compaction, abundant chemical compaction, and calcite cementation, which contributed to the heterogeneous pore structures with poor pore connectivity. A four-stage, conceptual model of pore evolution of cap rocks is presented to reveal how the diagenetic evolution of cap rocks determines the heterogeneity of their sealing capacity in carbonate reservoirs.</p
OmniQuant: Omnidirectionally Calibrated Quantization for Large Language Models
Large language models (LLMs) have revolutionized natural language processing
tasks. However, their practical deployment is hindered by their immense memory
and computation requirements. Although recent post-training quantization (PTQ)
methods are effective in reducing memory footprint and improving the
computational efficiency of LLM, they hand-craft quantization parameters, which
leads to low performance and fails to deal with extremely low-bit quantization.
To tackle this issue, we introduce an Omnidirectionally calibrated Quantization
(OmniQuant) technique for LLMs, which achieves good performance in diverse
quantization settings while maintaining the computational efficiency of PTQ by
efficiently optimizing various quantization parameters. OmniQuant comprises two
innovative components including Learnable Weight Clipping (LWC) and Learnable
Equivalent Transformation (LET). LWC modulates the extreme values of weights by
optimizing the clipping threshold. Meanwhile, LET tackles activation outliers
by shifting the challenge of quantization from activations to weights through a
learnable equivalent transformation. Operating within a differentiable
framework using block-wise error minimization, OmniQuant can optimize the
quantization process efficiently for both weight-only and weight-activation
quantization. For instance, the LLaMA-2 model family with the size of 7-70B can
be processed with OmniQuant on a single A100-40G GPU within 1-16 hours using
128 samples. Extensive experiments validate OmniQuant's superior performance
across diverse quantization configurations such as W4A4, W6A6, W4A16, W3A16,
and W2A16. Additionally, OmniQuant demonstrates effectiveness in
instruction-tuned models and delivers notable improvements in inference speed
and memory reduction on real devices. Codes and models are available at
\url{https://github.com/OpenGVLab/OmniQuant}.Comment: Updated result with 2-bit quantization. A differentiable quantization
method for LL
Orbital forcing of tropical climate dynamics in the Early Cambrian
peer reviewedAccording to modern atmospheric circulation models, the Intertropical Convergence Zone (ITCZ), as the Earth's meteorological equator, plays an essential role in the low-latitude hydrologic cycles. The limited availability of high-resolution tropical climate archives, especially from the Early Paleozoic Era, severely limits our understanding of ITCZ migration dynamics in deep time. Here we present high-resolution climate-proxy records (i.e., magnetic susceptibility (MS) and Zirconium/Aluminum (Zr/Al)) from tropical marine sediments of the ∼526-million-year-old Qiongzhusi Formation in South China to investigate the link between orbitally forced insolation changes, ITCZ migration dynamics, and low-latitude climate processes. These orbital-scale variations in MS and Zr/Al series are interpreted as alternations between wet and dry cycles, controlled by monsoon intensity under the orbitally forced ITCZ-related paleo-Hadley Cell dynamics. Our results show that combined precession and obliquity orbital cycles had an impact on the Early Cambrian ITCZ migration. Specifically, the precession and obliquity forcing shift the mean position of the ITCZ latitudinally by changing the interhemispheric pressure contrasts, thus affecting the low latitude hydroclimate cycle. We report semi-precession cycles of 8.3–7.9 kyr, which were probably associated with the twice-annual passage of the ITCZ across the intertropical zone, consistent with the paleogeographical location of South China near the equator during the Early Cambrian. Observed ∼1.1 – ∼1.5 Myr eccentricity amplitude modulation (AM) cycles and ∼ 1.0 – ∼1.2 Myr obliquity AM cycles may provide geological evidence for the chaotic motion between Earth and Mars in the Early Cambrian
Bleeding and thrombotic risk in pregnant women with Fontan physiology
Background/objectives Pregnancy may potentiate the inherent hypercoagulability of the Fontan circulation, thereby amplifying adverse events. This study sought to evaluate thrombosis and bleeding risk in pregnant women with a Fontan. Methods We performed a retrospective observational cohort study across 13 international centres and recorded data on thrombotic and bleeding events, antithrombotic therapies and pre-pregnancy thrombotic risk factors. Results We analysed 84 women with Fontan physiology undergoing 108 pregnancies, average gestation 33 +/- 5 weeks. The most common antithrombotic therapy in pregnancy was aspirin (ASA, 47 pregnancies (43.5%)). Heparin (unfractionated (UFH) or low molecular weight (LMWH)) was prescribed in 32 pregnancies (30%) and vitamin K antagonist (VKA) in 10 pregnancies (9%). Three pregnancies were complicated by thrombotic events (2.8%). Thirty-eight pregnancies (35%) were complicated by bleeding, of which 5 (13%) were severe. Most bleeds were obstetric, occurring antepartum (45%) and postpartum (42%). The use of therapeutic heparin (OR 15.6, 95% CI 1.88 to 129, p=0.006), VKA (OR 11.7, 95% CI 1.06 to 130, p=0.032) or any combination of anticoagulation medication (OR 13.0, 95% CI 1.13 to 150, p=0.032) were significantly associated with bleeding events, while ASA (OR 5.41, 95% CI 0.73 to 40.4, p=0.067) and prophylactic heparin were not (OR 4.68, 95% CI 0.488 to 44.9, p=0.096). Conclusions Current antithrombotic strategies appear effective at attenuating thrombotic risk in pregnant women with a Fontan. However, this comes with high (>30%) bleeding risk, of which 13% are life threatening. Achieving haemostatic balance is challenging in pregnant women with a Fontan, necessitating individualised risk-adjusted counselling and therapeutic approaches that are monitored during the course of pregnancy
Extensional tectonics and sedimentary response of the Early–Middle Cambrian passive continental margin, Tarim Basin, Northwest China
The fact that several half-grabens and normal faults developed in the Lower–Middle Cambrian of Tazhong (central Tarim Basin) and Bachu areas in Tarim Basin, northwest China, indicates that Tarim Basin was under extensional tectonic setting at this time. The half-grabens occur within a linear zone and the normal faults are arranged in en echelon patterns with gradually increasing displacement eastward. Extensional tectonics resulted in the formation of a passive continental margin in the southwest and a cratonic margin depression in the east, and most importantly, influenced the development of a three-pronged rift in the northeast margin of the Tarim Basin. The fault system controlled the development of platform – slope – bathyal facies sedimentation of mainly limestone-dolomite-gypsum rock-saline rock-red beds in the half-grabens. The NW-SE trending half-grabens reflect the distribution of buried basement faults
Microstructure and mechanical properties of Ti6321 alloy welded joint by EBW
Titanium and its alloys have excellent combination of properties, such as low density, high specific strength and corrosion resistance, and they are extensively used in many industrial fields. This work is aiming at investigation on the microstructure and mechanical properties of Ti–6Al–3Nb–2Zr–1Mo (Ti6321) alloy joints by Electron beam welding (EBW). The results show that the microstructure of the weld metal (WM) is composed of a mixture of acicular α, acicular α′, and β. The heat affected zone (HAZ) near WM consists of acicular α, primary α, acicular β phase and lots of acicular martensite α′. The HAZ near base metal consists of primary α phase and transformed β containing acicular α. The micro-hardness of the weld metal and heat affected zone are higher than that of base metal, and there are the peak values for the HAZ near the weld metal. The tensile strength of joint is equal to that of base metal, and the fracture locations of all the tensile specimens are in base metal, and it is well in accordance with the relationship between microstructure and mechanical properties of welded joints. Keywords: Ti6321, Electron beam welding, Microstructure, Propertie
Spectrum Medical Quantum or Terumo CDI 500: Which Device Measures Hemoglobin and Oxygen Saturation Most Accurately When Compared to a Benchtop Blood Analyzer?
To examine the accuracy between analyzers, the Terumo CDI 500 and the Spectrum Medical Quantum were compared to each other and to the ABL90 FLEX benchtop blood analyzer. Patients were retrospectively identified who underwent cardiac surgery requiring cardiopulmonary bypass between August 1, 2018 and November 1, 2019. Hemoglobin and venous saturation (SvO2) values from all three analyzers were collected. Measurements from the Quantum and the CDI 500 were averaged over 1 minute to provide a single value for the minute for the given device. Blood analysis on the ABL90 benchtop device was performed at a minimum of every hour during congenital cardiopulmonary bypass (CPB). There were 519 patients included in the analysis. Data points numbering 69,404 and 70,598 were analyzed when comparing the CDI 500 to the Quantum for hemoglobin and SvO2, respectively. Comparison of hemoglobin and SvO2 for the CDI 500 and Quantum versus ABL90 used 2283 and 1414 data points respectively, in each group. The CDI 500 and Quantum reported hemoglobin within 1 g/dL of the ABL90 86.9% and 87.5% of the time, respectively. The CDI 500 and Quantum reported SvO2 within 3% of the ABL90 61.0% and 57.9% of the time, respectively. The mean difference between the CDI 500 and Quantum hemoglobin and SvO2 measurements equaled .194 g/dL (p < .001) and .861% (p < .001), respectively and were both significantly different from zero. All device comparisons were statistically significantly different when compared to zero difference, likely due to the large data set as the magnitudes of these differences are all quite small and may not be clinically significant. However, while the reader should judge for themselves based upon their specific practice, in our opinion, the 95% Limit of Agreement was too large for either the CDI 500 or Quantum hemoglobin and SvO2 values to be substituted for ABL90 values. As recommended by the manufacturers, the CDI 500 and Quantum should only be used as a trending device
FR-PatchCore: An Industrial Anomaly Detection Method for Improving Generalization
In recent years, a multitude of self-supervised anomaly detection algorithms have been proposed. Among them, PatchCore has emerged as one of the state-of-the-art methods on the widely used MVTec AD benchmark due to its efficient detection capabilities and cost-saving advantages in terms of labeled data. However, we have identified that the PatchCore similarity principal approach faces significant limitations in accurately locating anomalies when there are positional relationships between similar samples, such as rotation, flipping, or misaligned pixels. In real-world industrial scenarios, it is common for samples of the same class to be found in different positions. To address this challenge comprehensively, we introduce Feature-Level Registration PatchCore (FR-PatchCore), which serves as an extension of the PatchCore method. FR-PatchCore constructs a feature matrix that is extracted into the memory bank and continually updated using the optimal negative cosine similarity loss. Extensive evaluations conducted on the MVTec AD benchmark demonstrate that FR-PatchCore achieves an impressive image-level anomaly detection AUROC score of up to 98.81%. Additionally, we propose a novel method for computing the mask threshold that enables the model to scientifically determine the optimal threshold and accurately partition anomalous masks. Our results highlight not only the high generalizability but also substantial potential for industrial anomaly detection offered by FR-PatchCore
Additional file 1 of Development of a multiple cross displacement amplification combined with nanoparticles-based biosensor assay for rapid and sensitive detection of Streptococcus pyogenes
Additional file 1
Degradation State Recognition of Piston Pump Based on ICEEMDAN and XGBoost
Under different degradation conditions, the complexity of natural oscillation of the piston pump will change. Given the difference of the characteristic values of the vibration signal under different degradation states, this paper presents a degradation state recognition method based on improved complete ensemble empirical mode decomposition with adaptive noise (ICEEMDAN) and eXtreme gradient boosting (XGBoost) to improve the accuracy of state recognition. Firstly, ICEEMDAN is proposed to alleviate the mode mixing phenomenon, which decomposes the vibration signal and obtain the intrinsic mode functions (IMFs) with less noise and more physical meaning, and subsequently the optimal IMF is found by using the correlation coefficient method. Then, the time domain, frequency domain, and entropy of the effective IMF are calculated, and the new characteristic values which can represent the degradation state are selected by principal component analysis (PCA) that it realizes dimension reduction. Finally, the above-mentioned characteristic indexes are used as the input of the XGBoost algorithm to achieve the recognition of the degradation state. In this paper, the vibration signals of four different degradation states are generated and analyzed through the piston pump slipper degradation experiment. By comparing the proposed method with different state recognition algorithms, it can be seen that the method based on ICEEMDAN and XGBoost is accurate and efficient, the average accuracy rate can reach more than 99%. Therefore, this method can more accurately describe the degradation state of the piston pump and has a highly practical application value
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