Aspirin for Primary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Controlled Trials and Subgroup Analysis by Sex and Diabetes Status

Objective: To evaluate the benefits and harms of aspirin for the primary prevention of CVD and determine whether the effects vary by sex and diabetes status. Methods: We searched Medline, Embase, and Cochrane databases for randomized controlled trials comparing the effects of aspirin with placebo or control in people with no pre-existing CVD. Two investigators independently extracted data and assessed the study quality. Analyses were performed using Stata version 12. Results: Fourteen trials (107,686 participants) were eligible. Aspirin was associated with reductions in major cardiovascular events (risk ratio, 0.90; 95% confidence interval, 0.85–0.95), myocardial infarction (0.86; 0.75–0.93), ischemic stroke (0.86; 0.75–0.98) and all-cause mortality (0.94; 0.89–0.99). There were also increases in hemorrhagic stroke (1.34; 1.01–1.79) and major bleeding (1.55; 1.35–1.78) with aspirin. The number needed to treat to prevent 1 major cardiovascular event over a mean follow-up of 6.8 years was 284. By comparison, the numbers needed to harm to cause 1 major bleeding is 299. In subgroup analyses, pooled results demonstrated a reduction in myocardial infarction among men (0.71; 0.59–0.85) and ischemic stroke among women (0.77; 0.63–0.93). Aspirin use was associated with a reduction (0.65; 0.51–0.82) in myocardial infarction among diabetic men. In meta-regression analyses, the results suggested that aspirin therapy might be associated with a decrease in stroke among diabetic women and a decrease in MI among diabetic men and risk reductions achieved with low doses (75 mg/day) were as large as those obtained with higher doses (650 mg/day). Conclusions: The use of low-dose aspirin was beneficial for primary prevention of CVD and the decision regarding an aspirin regimen should be made on an individual patient basis. The effects of aspirin therapy varied by sex and diabetes status. A clear benefit of aspirin in the primary prevention of CVD in people with diabetes needs more trials

Preparation of SiC coated graphite composite powders by nitriding combustion synthesis

Ceramic-coated graphite powders are considered as effective raw materials to fabricate three-dimensional continuous ceramic skeleton-reinforced graphite matrix composites which can overcome their inherent poor densification and improve their mechanical and antioxidation properties. However, the morphology and thickness regulation of ceramic coatings on graphite particles are still a great challenge. Herein, SiC-coated graphite (graphite@SiC) powders were prepared by nitriding combustion synthesis using Si and graphited mesocarbon microbead (MCMB) as raw powders with polytetrafluoroethylene (PTFE) as a promoter. The effects of the PTFE content and the Si/MCMB molar ratio on the phase composition and coating morphology were investigated. The phase transition and microstructure evolution of a combustion synthesis (CS) process were revealed by a gas-released quenching experiment. When the Si/MCMB molar ratio was 1 : 3 and the PTFE content was 10 wt%, the thickness of the SiC coating synthesized under 2 MPa N2 reached 1.14 μm. The corresponding sintered graphite@SiC composite had relative density of 99.2% and flexural strength of 231 MPa, accompanied by a significant improvement in high-temperature antioxidation properties. The as-synthesized graphite@SiC powders with good sinterability and antioxidation properties show great promise for applications in the nuclear industry and other extreme fields

Multiparametric MRI radiomics for the differentiation of brain glial cell hyperplasia from low-grade glioma

Abstract Background Differentiating between low-grade glioma and brain glial cell hyperplasia is crucial for the customized clinical treatment of patients. Objective Based on multiparametric MRI imaging and clinical risk factors, a radiomics-clinical model and nomogram were constructed for the distinction of brain glial cell hyperplasia from low-grade glioma. Methods Patients with brain glial cell hyperplasia and low-grade glioma who underwent surgery at the First Affiliated Hospital of Soochow University from March 2016 to March 2022 were retrospectively included. In this study, A total of 41 patients of brain glial cell hyperplasia and 87 patients of low-grade glioma were divided into training group and validation group randomly at a ratio of 7:3. Radiomics features were extracted from T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (T1-enhanced). Then, LASSO, SVM, and RF models were created in order to choose a model with a greater level of efficiency for calculating each patient’s Rad-score (radiomics score). The independent risk factors were identified via univariate and multivariate logistic regression analysis to filter the Rad-score and clinical risk variables in turn. A radiomics-clinical model was next built of which effectiveness was assessed. Results Brain glial cell hyperplasia and low-grade gliomas from the 128 cases were randomly divided into 10 groups, of which 7 served as training group and 3 as validation group. The mass effect and Rad-score were two independent risk variables used in the construction of the radiomics-clinical model, and their respective AUCs for the training group and validation group were 0.847 and 0.858. The diagnostic accuracy, sensitivity, and specificity of the validation group were 0.821, 0.750, and 0.852 respectively. Conclusion Combining with radiomics constructed by multiparametric MRI images and clinical features, the radiomics-clinical model and nomogram that were developed to distinguish between brain glial cell hyperplasia and low-grade glioma had a good performance

SGLT-2 Inhibitors for Non-Alcoholic Fatty Liver Disease: A Review

Non-alcoholic fatty liver disease (NAFLD) is a group of metabolic liver illnesses that lead to accumulation of liver fat mainly due to excessive nutrition. It is closely related to insulin resistance, obesity, type 2 diabetes, and cardiovascular disease, and has become one of the main causes of chronic liver disease worldwide. At present, there is no specific drug for the treatment of NAFLD; lifestyle interventions including dietary control and exercise are recommended as routine treatments. As a drug for the treatment of type 2 diabetes, sodium-glucose co-transporter type 2 (SGLT-2) inhibitors may also play a beneficial role in the treatment of NAFLD. This article reviews the mechanism of SGLT-2 inhibitors in the treatment of NAFLD

Characteristics of pantograph-catenary arc under low air pressure and strong airflow

Pantograph-catenary arc fault is the primary factor threatening the stability of the power transmission for high-speed railway. The motion characteristics of the pantograph-catenary arc under low air pressure and strong airflow is significantly different from the case under atmospheric pressure. In this paper, an experimental platform of pantograph-catenary arc was built to investigate arc root position-time and arc column longitudinal drift height-time characteristic curves under different air pressures and airflow velocites. Via analysing the corresponding results, it can be found that there are different arc root–arc column traction mechanisms at different stages of arc development. The arcing time and arc root stagnation time under low air pressure are significantly longer than the case under atmospheric pressure, resulting in more serious electrode ablation. The arc column longitudinal drift velocity and height are greater with the increase of airflow velocity. Two typical irregular arc motion phenomena—arc root jumping and arc reignition are observed. To clarify the internal mechanism of the above phenomenon, a magnetohydrodynamics (MHD) model of the pantograph-catenary arc was lauched, the influence mechanism of the pantograph-catenary arc temperature and voltage are studied, and the physical process of arc temperature oscillation is analysed. The research results provide theoretical support for arc protection in high-altitude areas.Published versionFunding Information: NEEC project, Grant/Award Number: NEEC‐2018‐B06; National Natural Science Foundation of China, Grant/Award Numbers: 51807167, 51837009, 51922090, 52077182, U19A20105; Science and Technology Project of Headquarter of SGCC, Grant/Award Number: SGTYHT/19‐JS‐215

provenanceofcentralcanyoninqiongdongnanbasinasevidencedbydetritalzirconupbstudyofuppermiocenesandstones

Deep-water canyon systems can provide important sandstone reservoirs for deep-water oil and gas exploration in the South China Sea; however, the sedimentary provenance of the Central Canyon in the Qiongdongnan Basin remains controversial. In this work, detrital zircon grains from three drilling sandstones in the Upper Miocene Huangliu Formation in the western part of the Central Canyon were analysed by LA-ICP-MS for U-Pb ages, in order to constrain their provenance. One hundred and ninety-one zircon grains yield concordant U-Pb ages ranging from 28.6 to 3285 Ma. Most of them show oscillatory or linear zoning in CL-images and high Th/U ratios (> 0.1), suggesting that they are magmatic zircons. Three major age clusters at about 30 Ma (N=6), 220-270 Ma (N=29), and 420-440 Ma (N=13), and five minor age clusters at 70-110 Ma (N=7), 150-170 Ma (N=4), 800-850 Ma (N=11), 1800-2000 Ma (N=16), and 2400-2600 Ma (N=7), can be identified in the age spectrum, which are very similar to those of the Upper Miocene sandstones and modern river sands in the Red River area, but different from those of other nearby regions (e.g., Hainan Island, the Pearl River area, and the Mekong River area) in Southeast Asia. The major age peak at about 30 Ma in our samples is consistent with the timing of tectonothermal events in the Red River Fault Zone. Therefore, we suggest that the provenance of the western part of the Central Canyon, in the Qiongdongnan Basin, was fed dominantly by the Paleo-Red River system during the Late Miocene

Influence of Interface Temperature on the Electric Contact Characteristics of a C-Cu Sliding System

Electrical contact resistance (ECR) and discharge are the key parameters of electrical contact performance for carbon-copper (C-Cu) contacts in the pantograph-contact line system. The change in physical and chemical properties of the C-Cu interface caused by interface temperature is the main reason for the variation in ECR and discharge. In this paper, an electric contact test platform based on interface temperature control was established. The influence of interface temperature on ECR and the discharge characteristics under different current amplitudes were studied. There are opposite trends in the change in ECR and the discharge characteristics with interface temperature under different currents, which results from the competition between interface oxidation and a softening of the contact spots caused by high temperature. The trend of interface oxidation with temperature was analyzed via the quantitative analysis of the composition and content of the oxides at the C-Cu contact interface and is discussed here. The relationship between interface oxidation, ECR, and discharge characteristics was studied. Furthermore, a finite element simulation model was established for estimating the temperature distribution throughout the C-Cu contact spots. The competitive process of the softening and oxidation of the contact spots at different temperatures and currents was analyzed, and the variation mechanism of the ECR and discharge characteristics with interface temperature was studied