A Mathematical Model for Ballast Tamping Decision Making in Railway Tracks

Ballast tamping is considered as an important maintenance process for railway infrastructures and has a large influence on the capacity of any railway networks. But optimizing the plan of that process is a complex problem with a high cost. This paper discusses optimizing tamping operations on ballasted tracks to improve the track geometry and reduce the total maintenance cost. A mathematical model for this problem in the literature is improved here by including the restriction on the resources (tools, workers and budget) in the model and including constant/variable values for track possession cost and available resources. The optimal solutions obtained for all instances are found by using the global optimization. Besides, a numerical study is presented to test and evaluate the model performance. The results show that the proposed model can be adopted by the infrastructure manager (IM) to make suitable tamping scheduling decisions under normal or private conditions; however, the private conditions lead to an increase of the final cost compared to that of the normal ones. Doi: 10.28991/cej-2020-03091601 Full Text: PD

G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension

Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the non-genomic pathways of aldosterone while the hormone simultaneously interacts with mineralocorticoid receptor. In contrast to its cardio-protective role in postmenopausal women via its interaction with estrogen, GPER seems to trigger vasoconstriction effects and can further induce water and sodium retention in the presence of aldosterone, indicating two entirely different binding sites and effects for estrogen and aldosterone. Accumulating evidence also points to a role of aldosterone in mediating hypertension and its risk factors via the interaction with GPER. Therefore, with this review, we aimed to summarize the research on these interactions to help (1) elucidate the role of GPER activated by aldosterone in the blood vessels, heart, and kidney; (2) compare the non-genomic actions between aldosterone and estrogen mediated by GPER; and (3) address the potential of GPER as a new promising therapeutic target for aldosterone-induced hypertension

In Situ Test of Grouting Reinforcement for Water-Enriched Sandy Gravel Ground in River Floodplain

The performance of the ground treatment is always critical for a tunnel excavated in unstable stratum. Laodongnanlu Xiangjiang Tunnel (Changsha, China) across the Xiangjiang River will be constructed in a sandy gravel ground which is characterized by loose structure, extensive porosity, elevated sensitivity, poor stability, and a high groundwater table. Permeation grouting will be employed to improve the bearing capacity and mitigate groundwater movement into the excavation. In order to seek suitable injection parameters and grouting method, a field trial of vertical grouting was conducted in the sandy gravel stratum in river floodplain. A series of tests focusing on grout material, grouting sequence of boreholes, injection pressure, and grouting volume were performed to improve the sandy gravel mass strength and reduce water permeability. The examination of the results obtained during water pressure testing and core drilling on completion of the grouting trial successfully demonstrated that the specified injection criteria had led to an expected effect. Grouting control method of this saturated sandy gravel stratum was concluded after the test, which would contribute to the future pregrouting work during the tunnelling

Network analysis of the relationships between problematic smartphone use and anxiety, and depression in a sample of Chinese college students

BackgroundProblematic smartphone use (PSU) is associated with both anxiety and depression. However, the relationships between components of PSU and symptoms of anxiety or depression have not been investigated. Hence, the aim of this study was to closely examine the relationships between PSU and anxiety and depression to identify the pathological mechanisms underpinning those relationships. A second aim was to identify important bridge nodes to identify potential targets for intervention.MethodsSymptom-level network structures of PSU and anxiety, and PSU and depression were constructed to investigate the connections between the variables and evaluate the bridge expected influence (BEI) of each node. Network analysis using data from 325 Chinese healthy college students was performed.ResultsFive strongest edges appeared within the communities in both the PSU-anxiety and PSU-depression networks. The “Withdrawal” component had more connections with symptoms of anxiety or depression than any other PSU node. In particular, the edges between “Withdrawal” and “Restlessness” and between “Withdrawal” and “Concentration difficulties” were the strongest cross-community edges in the PSU-anxiety network and PSU-depression network, respectively. Furthermore, “Withdrawal” had the highest BEI in the PSU community in both networks.ConclusionsThese findings provide preliminary evidence of the pathological pathways linking PSU with anxiety and depression, with “Withdrawal” linking PSU with both anxiety and depression. Hence, “Withdrawal” may be a potential target for preventing and intervening in cases of anxiety or depression

Application of Zebrafish Models in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, recurrent, and remitting inflammatory disease with unclear etiology. As a clinically frequent disease, it can affect individuals throughout their lives, with multiple complications. Unfortunately, traditional murine models are not efficient for the further study of IBD. Thus, effective and convenient animal models are needed. Zebrafish have been used as model organisms to investigate IBD because of their suggested highly genetic similarity to humans and their superiority as laboratory models. The zebrafish model has been used to study the composition of intestinal microbiota, novel genes, and therapeutic approaches. The pathogenesis of IBD is still unclear and many risk factors remain unidentified. In this review, we compare traditional murine models and zebrafish models in terms of advantages, pathogenesis, and drug discovery screening for IBD. We also review the progress and deficiencies of the zebrafish model for scientific applications

A Three-Stage Stirling Pulse Tube Cryocooler Approaching 4 K

Presented at the 16th International Cryocooler Conference, held May 17-20, 2008 in Atlanta, Georgia.It is a great challenge for a Stirling Pulse tube cryocooler (PTC) to reach liquid-helium temperature, where there are promising applications such as superconducting digital electronics, midinfrared instrument, heterodyne detectors. Lockheed Martin first achieved a temperature below 4 K with a four-stage configuration with He-3 as working fluid. A single-stage Stirling PTC precooled by a self-made two-stage GM-type PTC has been constructed and tested to explore the loss mechanism of 4 K PTC working at high frequency at Zhejiang University. Temperature as low as 4.2 K has been successfully obtained with He-4 as working fluid by the end of 2008. In this paper, we report a newly-designed three-stage PTC, which aims to reach 4 K. The 4 K cooler is a thermalcoupled type, whose mass flows are easier t ocontrol and whose energy flows are more readily monitored. It will be working with He-4 instead of He-3. The first and second stages have been finished. A bottom temperature of 35 K and 9 W at 77 K with 300 We input has been achieved in the first stage. The bottom temperature of second stage is as low as 20.6 K, and the cooling power is measured as 1.0 W at 28.6 K. The test results are in good agreement with the model for both stages. The first and second stage is designed to couple with the a stage, which is expected to reach below 5.0 K at 30 Hz

Mechanisms Of Cannabinoid Cb 2 Receptor-Mediated Reduction Of Dopamine Neuronal Excitability In Mouse Ventral Tegmental Area

Background: We have recently reported that activation of cannabinoid type 2 receptors (CB 2 Rs)reduces dopamine (DA)neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods: Patch-clamp recordings were performed in mouse VTA slices and dissociated single VTA DA neurons. Findings: Using cell-attached recording in VTA slices, bath-application of CB 2 R agonists (JWH133 or five other CB 2 R agonists)significantly reduced VTA DA neuron action potential (AP)firing rate. Under the patch-clamp whole-cell recording model, JWH133 (10 μM)mildly reduced the frequency of miniature excitatory postsynaptic currents (mEPSCs)but not miniature inhibitory postsynaptic currents (mIPSCs). JWH133 also did not alter evoked EPSCs or IPSCs. In freshly dissociated VTA DA neurons, JWH133 reduced AP firing rate, delayed AP initiation and enhanced AP after-hyperpolarization. In voltage-clamp recordings, JWH133 (1 μM)enhanced M-type K + currents and this effect was absent in CB 2−/− mice and abolished by co-administration of a selective CB 2 R antagonist (10 μM, AM630). CB 2 R-mediated inhibition in VTA DA neuron firing can be mimicked by M-current opener (10 μM retigabine)and blocked by M-current blocker (30 μM XE991). In addition, enhancement of neuronal cAMP by forskolin (10 μM)reduced M-current and increased DA neuron firing rate. Finally, pharmacological block of synaptic transmission by NBQX (10 μM), D-APV (50 μM)and picrotoxin (100 μM)in VTA slices failed to prevent CB 2 R-mediated inhibition, while intracellular infusion of guanosine 5\u27-O-2-thiodiphosphate (600 μM, GDP-β-S)through recording electrode to block postsynaptic G-protein function prevented JWH133-induced reduction in AP firing. Interpretation: Our results suggest that CB 2 Rs modulate VTA DA neuron excitability mainly through an intrinsic mechanism, including a CB 2 R-mediated reduction of intracellular cAMP, and in turn enhancement of M-type K + currents. Fund: This research was supported by the Barrow Neuroscience Foundation, the BNI-BMS Seed Fund, and CNSF (81771437)

Effect of Axial Force on the Performance of Micromachined Vibratory Rate Gyroscopes

It is reported in the published literature that the resonant frequency of a silicon micromachined gyroscope decreases linearly with increasing temperature. However, when the axial force is considerable, the resonant frequency might increase as the temperature increases. The axial force is mainly induced by thermal stress due to the mismatch between the thermal expansion coefficients of the structure and substrate. In this paper, two types of micromachined suspended vibratory gyroscopes with slanted beams were proposed to evaluate the effect of the axial force. One type was suspended with a clamped-free (C-F) beam and the other one was suspended with a clamped-clamped (C-C) beam. Their drive modes are the bending of the slanted beam, and their sense modes are the torsion of the slanted beam. The relationships between the resonant frequencies of the two types were developed. The prototypes were packaged by vacuum under 0.1 mbar and an analytical solution for the axial force effect on the resonant frequency was obtained. The temperature dependent performances of the operated mode responses of the micromachined gyroscopes were measured. The experimental values of the temperature coefficients of resonant frequencies (TCF) due to axial force were 101.5 ppm/°C for the drive mode and 21.6 ppm/°C for the sense mode. The axial force has a great influence on the modal frequency of the micromachined gyroscopes suspended with a C-C beam, especially for the flexure mode. The quality factors of the operated modes decreased with increasing temperature, and changed drastically when the micromachined gyroscopes worked at higher temperatures

Exploring the Potential of Integrated Optical Sensing and Communication (IOSAC) Systems with Si Waveguides for Future Networks

Advanced silicon photonic technologies enable integrated optical sensing and communication (IOSAC) in real time for the emerging application requirements of simultaneous sensing and communication for next-generation networks. Here, we propose and demonstrate the IOSAC system on the silicon nitride (SiN) photonics platform. The IOSAC devices based on microring resonators are capable of monitoring the variation of analytes, transmitting the information to the terminal along with the modulated optical signal in real-time, and replacing bulk optics in high-precision and high-speed applications. By directly integrating SiN ring resonators with optical communication networks, simultaneous sensing and optical communication are demonstrated by an optical signal transmission experimental system using especially filtering amplified spontaneous emission spectra. The refractive index (RI) sensing ring with a sensitivity of 172 nm/RIU, a figure of merit (FOM) of 1220, and a detection limit (DL) of 8.2*10-6 RIU is demonstrated. Simultaneously, the 1.25 Gbps optical on-off-keying (OOK) signal is transmitted at the concentration of different NaCl solutions, which indicates the bit-error-ratio (BER) decreases with the increase in concentration. The novel IOSAC technology shows the potential to realize high-performance simultaneous biosensing and communication in real time and further accelerate the development of IoT and 6G networks.Comment: 11pages, 5 figutre