Fermi Large Area Telescope observations of the supernova remnant HESS J1731-347

Context: HESS J1731-347 has been identified as one of the few TeV-bright shell-type supernova remnants (SNRs). These remnants are dominated by nonthermal emission, and the nature of TeV emission has been continuously debated for nearly a decade. Aims: We carry out the detailed modeling of the radio to gamma-ray spectrum of HESS J1731-347 to constrain the magnetic field and energetic particles sources, which we compare with those of the other TeV-bright shell-type SNRs explored before. Methods: Four years of data from Fermi Large Area Telescope (LAT) observations for regions around this remnant are analyzed, leading to no detection correlated with the source discovered in the TeV band. The Markov Chain Monte Carlo method is used to constrain parameters of one-zone models for the overall emission spectrum. Results: Based on the 99.9% upper limits of fluxes in the GeV range, one-zone hadronic models with an energetic proton spectral slope greater than 1.8 can be ruled out, which favors a leptonic origin for the gamma-ray emission, making this remnant a sibling of the brightest TeV SNR RX J1713.7-3946, the Vela Junior SNR RX J0852.0-4622, and RCW 86. The best-fit leptonic model has an electron spectral slope of 1.8 and a magnetic field of about 30 muG, which is at least a factor of 2 higher than those of RX J1713.7-3946 and RX J0852.0-4622, posing a challenge to the distance estimate and/or the energy equipartition between energetic electrons and the magnetic field of this source. A measurement of the shock speed will address this challenge and has implications on the magnetic field evolution and electron acceleration driven by shocks of SNRs.Comment: 7 pages, 3 fogures, A&A in pres

Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS

Gate-Tunable Tunneling Resistance in Graphene/Topological Insulator Vertical Junctions

Graphene-based vertical heterostructures, particularly stacks incorporated with other layered materials, are promising for nanoelectronics. The stacking of two model Dirac materials, graphene and topological insulator, can considerably enlarge the family of van der Waals heterostructures. Despite well understanding of the two individual materials, the electron transport properties of a combined vertical heterojunction are still unknown. Here we show the experimental realization of a vertical heterojunction between Bi2Se3 nanoplate and monolayer graphene. At low temperatures, the electron transport through the vertical heterojunction is dominated by the tunneling process, which can be effectively tuned by gate voltage to alter the density of states near the Fermi surface. In the presence of a magnetic field, quantum oscillations are observed due to the quantized Landau levels in both graphene and the two-dimensional surface states of Bi2Se3. Furthermore, we observe an exotic gate-tunable tunneling resistance under high magnetic field, which displays resistance maxima when the underlying graphene becomes a quantum Hall insulator

Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway

The diterpenoid compound, Oridonin, extracted from the Chinese herb, Rabdosia rubescens, possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition of the Notch pathway in our in vitro study; therefore, its potential therapeutic effects were further investigated in the animal model of human Guillain-Barré syndrome (GBS) and other polyneuropathies – experimental autoimmune neuritis (EAN). Either preventive or therapeutic treatments with Oridonin greatly attenuated disease peak severity, suppressed paraparesis, shortened disease duration, and even delayed EAN onset. Progression of neuropathic pain, demyelination, inflammatory cellular accumulations, and inflammatory cytokines in peripheral nerves were significantly attenuated. Meanwhile, accumulation of immune cells in the spinal roots and microglial activation in the lumbar spinal cord were also reduced. Interestingly, Oridonin treatment significantly increased the proportion of anti-inflammatory macrophages and made them locally dominant among all infiltrated macrophages in the peripheral nerves. The down-regulation of local Notch pathway proteins, together with our in vitro results indicated their possible involvement. Taken together, our results demonstrated that Oridonin effectively suppressed EAN by attenuating local inflammatory reaction and increasing the proportion of immune regulating macrophages in the peripheral nerves, possibly through blockage of the Notch pathway, which suggests Oridonin as a potential therapeutic candidate for human GBS and neuropathies

Multi-wavelength study of the supernova remnant Kes 79 (G33.6+0.1): On its supernova properties and expansion into a molecular environment

Kes 79 (G33.6+0.1) is an aspherical thermal composite supernova remnant (SNR) observed across the electromagnetic spectrum and showing an unusual highly-structured morphology, in addition to harboring a central compact object (CCO). Using the CO J=1-0, J=2-1, and J=3-2 data, we provide the first direct evidence and new morphological evidence to support the physical interaction between the SNR and the molecular cloud at $V_LSR\sim 105$ km s$^{-1}$. We revisit the 380 ks XMM-Newton observations and perform a dedicated spatially resolved X-ray spectroscopic study with careful background subtraction. The overall X-ray-emitting gas is characterized by an under-ionized ($\tau_c \sim 6\times 10^{11}$ cm^${-3}$) cool ($kT_c \approx 0.20$ keV) plasma with solar abundances, plus an under-ionized ($\tau_h\sim 8\times 10^{10}$ cm$^{-3}$) hot ($kT_h\approx 0.80$ keV) plasma with elevated Ne, Mg, Si, S and Ar abundances. Kes 79 appears to have a double-hemisphere morphology viewed along the symmetric axis. Projection effect can explain the multiple shell structures and the thermal composite morphology. The X-ray filaments, spatially correlated with the 24 um IR filaments, are suggested to be due to the SNR shock interaction with dense gas, while the halo forms from SNR breaking out into a tenuous medium. The high-velocity, hot ($kT_h\sim 1.4$--1.6 keV) ejecta patch with high metal abundances, together with the non-uniform metal distribution across the SNR, indicating an asymmetric SN explosion of Kes 79. We refine the Sedov age to 4.4--6.7 kyr and the mean shock velocity to 730 km s$^{-1}$. Our multi-wavelength study suggests a progenitor mass of $\sim 15$--20 solar masses for the core-collapse explosion that formed Kes 79 and its CCO, PSR J1852+0040.Comment: 17 pages, 12 figures, 3 tables, published in Ap