An Application Case Study on Multi-sensor Data fusion System for Intelligent Process Monitoring

AbstractMulti-sensor data fusion is a technology to enable combining information from several sources in order to form a unified picture. Focusing on the indirect method, an attempt was made to build up a multi-sensor data fusion system to monitor the condition of grinding wheels with force signals and the acoustic emission (AE) signals. An artificial immune algorithm based multi-signals processing method was presented in this paper. The intelligent monitoring system is capable of incremental supervised learning of grinding conditions and quickly pattern recognition, and can continually improve the monitoring precision. The application case indicates that the accuracy of condition identification is about 87%, and able to meet the industrial need on the whole

Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.

In Arabidopsis, the salt overly sensitive (SOS) pathway, consisting of calcineurin B-like protein 4 (CBL4/SOS3), CBL-interacting protein kinase 24 (CIPK24/SOS2) and SOS1, has been well defined as a crucial mechanism to control cellular ion homoeostasis by extruding Na+ to the extracellular space, thus conferring salt tolerance in plants. CBL10 also plays a critical role in salt tolerance possibly by the activation of Na+ compartmentation into the vacuole. However, the functional relationship of the SOS and CBL10-regulated processes remains unclear. Here, we analyzed the genetic interaction between CBL4 and CBL10 and found that the cbl4 cbl10 double mutant was dramatically more sensitive to salt as compared to the cbl4 and cbl10 single mutants, suggesting that CBL4 and CBL10 each directs a different salt-tolerance pathway. Furthermore, the cbl4 cbl10 and cipk24 cbl10 double mutants were more sensitive than the cipk24 single mutant, suggesting that CBL10 directs a process involving CIPK24 and other partners different from the SOS pathway. Although the cbl4 cbl10, cipk24 cbl10, and sos1 cbl10 double mutants showed comparable salt-sensitive phenotype to sos1 at the whole plant level, they all accumulated much lower Na+ as compared to sos1 under high salt conditions, suggesting that CBL10 regulates additional unknown transport processes that play distinct roles from the SOS1 in Na+ homeostasis

SPIDER-WEB enables stable, repairable, and encryptible algorithms under arbitrary local biochemical constraints in DNA-based storage

DNA has been considered as a promising medium for storing digital information. Despite the biochemical progress in DNA synthesis and sequencing, novel coding algorithms need to be constructed under the specific constraints in DNA-based storage. Many functional operations and storage carriers were introduced in recent years, bringing in various biochemical constraints including but not confined to long single-nucleotide repeats and abnormal GC content. Existing coding algorithms are not applicable or unstable due to more local biochemical constraints and their combinations. In this paper, we design a graph-based architecture, named SPIDER-WEB, to generate corresponding graph-based algorithms under arbitrary local biochemical constraints. These generated coding algorithms could be used to encode arbitrary digital data as DNA sequences directly or served as a benchmark for the follow-up construction of coding algorithms. To further consider recovery and security issues existing in the storage field, it also provides pluggable algorithmic patches based on the generated coding algorithms: path-based correcting and mapping shuffling. They provide approaches for probabilistic error correction and symmetric encryption respectively.Comment: 30 pages; 12 figures; 2 table

Heavy Neutral Leptons in Gauged U(1)Lμ−LτU(1)_{L_\mu-L_\tau} at Muon Collider

Heavy neutral leptons $N$ are the most appealing candidates to generate the tiny neutrino masses. In this paper, we study the signature of heavy neutral leptons in gauged $U(1)_{L_\mu-L_\tau}$ at a muon collider. Charged under the $U(1)_{L_\mu-L_\tau}$ symmetry, the heavy neutral leptons can be pair produced via the new gauge boson $Z'$ at muon collider as $\mu^+\mu^-\to Z^{\prime *}\to NN$ and $\mu^+\mu^-\to Z^{\prime (*)} \gamma\to NN\gamma$. We then perform a detailed analysis on the lepton number violation signature $\mu^+\mu^-\to NN\to \mu^\pm\mu^\pm W^\mp W^\mp$ and $\mu^+\mu^-\to NN \gamma\to \mu^\pm\mu^\pm W^\mp W^\mp \gamma$ at the 3 TeV muon collider, where the hadronic decays of $W$ boson are treated as fat-jets $J$. These lepton number violation signatures have quite clean backgrounds at the muon collider. Our simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon collider. For instance, with new gauge coupling $g'=0.6$ and an integrated luminosity of 1000 fb$^{-1}$, the $\mu^\pm\mu^\pm JJ$ signal could probe $m_{Z'}\lesssim 12.5$ TeV. Meanwhile, if the gauge boson mass satisfies $2 m_N<m_{Z'}<\sqrt{s}$, the $\mu^\pm\mu^\pm JJ\gamma$ signature would be more promising than the $\mu^\pm\mu^\pm JJ$ signature.Comment: 20 pages, 8 figures, 2 table

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.

BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, can reduce EAE severity by protecting myelin from demyelination, its effect on immune responses in EAE has not yet been studied. METHODS: We investigated the effect of Mdivi-1, a small molecule inhibitor of Drp1, on EAE. Clinical scores, inflammation, demyelination and Drp1 activation in the central nervous system (CNS), and T cell responses in both CNS and periphery were determined. RESULTS: Mdivi-1 effectively suppressed EAE severity by reducing demyelination and cellular infiltration in the CNS. Mdivi-1 treatment decreased the phosphorylation of Drp1 (ser616) on CD4+ T cells, reduced the numbers of Th1 and Th17 cells, and increased Foxp3+ regulatory T cells in the CNS. Moreover, Mdivi-1 treatment effectively inhibited IFN-γ+, IL-17+, and GM-CSF+ CD4+ T cells, while it induced CD4+ Foxp3+ regulatory T cells in splenocytes by flow cytometry. CONCLUSIONS: Together, our results demonstrate that Mdivi-1 has therapeutic potential in EAE by modulating the balance between Th1/Th17 and regulatory T cells

Method of determining cosmological parameter ranges with samples of candles with an intrinsic distribution

In this paper, the effect of the intrinsic distribution of cosmological candles is investigated. We find that, in the case of a narrow distribution, the deviation of the observed modulus of sources from the expected central value could be estimated within a ceratin range. We thus introduce a lower and upper limits of $\chi ^{2}$, $\chi_{\min}^{2}$ and $\chi_{\max}^{2}$, to estimate cosmological parameters by applying the conventional minimizing $\chi ^{2}$ method. We apply this method to a gamma-ray burst (GRB) sample as well as to a combined sample including this GRB sample and an SN Ia sample. Our analysis shows that: a) in the case of assuming an intrinsic distribution of candles of the GRB sample, the effect of the distribution is obvious and should not be neglected; b) taking into account this effect would lead to a poorer constraint of the cosmological parameter ranges. The analysis suggests that in the attempt of constraining the cosmological model with current GRB samples, the results tend to be worse than what previously thought if the mentioned intrinsic distribution does exist.Comment: 6 pages,4 figures,1 tables.Data updated. Main conclusion unchange

N,N′-Di-p-tolyl­ethyl­enediamine

The asymmetric unit of the title compound, C16H20N2, contains two independent mol­ecules. The rings in each mol­ecule are oriented at dihedral angles of 78.94 (3) and 77.76 (3)°