Magic wavelengths for the 6s^2\,^1S_0-6s6p\,^3P_1^o transition in ytterbium atom

The static and dynamic electric-dipole polarizabilities of the 6s^2\,^1S_0 and 6s6p\,^3P_1^o states of Yb are calculated by using the relativistic ab initio method. Focusing on the red detuning region to the 6s^2\,^1S_0-6s6p\,^3P_1^o transition, we find two magic wavelengths at 1035.7(2) nm and 612.9(2) nm for the 6s^2\,^1S_0-6s6p\,^3P_1^o, M_J=0 transition and three magic wavelengthes at 1517.68(6) nm, 1036.0(3) nm and 858(12) nm for the 6s^2\,^1S_0-6s6p\,^3P_1^o, M_J=\pm1 transitions. Such magic wavelengths are of particular interest for attaining the state-insensitive cooling, trapping, and quantum manipulation of neutral Yb atom.Comment: 13 pages, 3 figure

Effects of behavioral response and vaccination policy on epidemic spreading - an approach based on evolutionary-game dynamics

date of Acceptance: 23/06/2014 This work was supported by the National Natural Science Foundation of China (Grant Nos. 11331009, 11135001, 11105025). Y.-C.L. was supported by AFOSR under Grant No. FA9550-10-1-0083.Peer reviewedPublisher PD

Epidemic Variability in Hierarchical Geographical Networks with Human Activity Patterns

Recently, some studies have revealed that non-Poissonian statistics of human behaviors stem from the hierarchical geographical network structure. On this view, we focus on epidemic spreading in the hierarchical geographical networks, and study how two distinct contact patterns (i. e., homogeneous time delay (HOTD) and heterogeneous time delay (HETD) associated with geographical distance) influence the spreading speed and the variability of outbreaks. We find that, compared with HOTD and null model, correlations between time delay and network hierarchy in HETD remarkably slow down epidemic spreading, and result in a upward cascading multi-modal phenomenon. Proportionately, the variability of outbreaks in HETD has the lower value, but several comparable peaks for a long time, which makes the long-term prediction of epidemic spreading hard. When a seed (i. e., the initial infected node) is from the high layers of networks, epidemic spreading is remarkably promoted. Interestingly, distinct trends of variabilities in two contact patterns emerge: high-layer seeds in HOTD result in the lower variabilities, the case of HETD is opposite. More importantly, the variabilities of high-layer seeds in HETD are much greater than that in HOTD, which implies the unpredictability of epidemic spreading in hierarchical geographical networks

An Eye on Travel: An Overview of Travel-Related Ocular Complications

Travellers are at risk of a diverse range of environmental and infectious conditions, some of which may affect the eyes and lead to blindness in severe cases. Travel-related ocular infections include onchocerciasis, leishmaniasis, cysticercosis, trachoma, dengue, loiasis, and leptospirosis. The travel medicine adviser should also recognise other hazards encountered during travel which may adversely affect the eye. These include recreational activities such as high altitude trekking, bungee jumping, skiing, scuba diving, and sun exposure. There is a subset of travellers who have underlying eye conditions, which predispose them to complications during international travel, including angle-closure glaucoma, and expansion of intraocular gas from previous vitreoretinal surgery. Contact lens wearers have a greater risk of ocular infection and corneal erosion during travel, especially where hygiene standards are low. Despite the susceptibility of the eye to infection, traumatic injury and environmental damage during international travel, this topic is not frequently discussed in the context of pre-travel consultations. Travel medicine professionals should have a reasonable knowledge of the major ocular risks associated with travel overseas

Poly[[tetraaqua­bis(μ3-1H-benzimidazole-5,6-dicarboxyl­ato)dicobalt(II)] trihydrate]

The title complex, {[Co2(C9H4N2O4)2(H2O)4]·3H2O}n, was synthesized hydro­thermally. The unique CoII ion is coordin­ated in a distorted octa­hedral coordination environment by two water mol­ecules and three symmetry-related 1H-benzimid­azole-5,6-dicarboxyl­ate (Hbidc) ligands. The Hbidc ligands coordinate via a bis-chelating and mono-chelating carboxyl­ate group and by an imidazole group N atom, bridging the CoII ions and forming an extended two-dimensional structure in the ab plane. In the crystal structure, inter­molecular N—H⋯O and O—H⋯O hydrogen bonds connect complex and solvent water mol­ecules, forming a three-dimensional supermolecular network. One of the solvent water mol­ecules lies on a twofold rotation axis

In-silico design of novel myocilin inhibitors for glaucoma therapy

Purpose: To explore newer computational approaches in the design of novel myocilin inhibitors for the treatment of glaucoma.Methods: An in-silico virtual screening technique based on simulation of molecular docking was utilised to design a novel myocilin inhibitors for the treatment of  glaucoma. The designed novel molecules were theoretically evaluated to predict their pharmacokinetic properties and toxic effects. Lead molecules were screened out in virtual screening technique on the basis of low binding energies obtained in AutoDock based molecular docking simulation.Results: Out of ten top lead compounds screened, ZINC01729523 and ZINC04692015 were promising, having shown potent inhibition of myocilin, good pharmacokinetic properties and absence of any toxic effects.Conclusion: In-silico virtual screening of molecular libraries containing a large number of ligands is very useful for short-listing of potential lead molecules for further structure-based discovery of antiglaucoma-drugs.Keywords: Glaucoma, Myocilin, Docking, Virtual-screening, Autodock, Ligand, Drug desig