Strategi Pembangunan Pariwisata melalui Sinergitas Dinas Pariwisata dengan Desa Adat ( Studi Kasus pada Pengelolaan Obyek Wisata Pantai Labuan Sait dalam Meningkatkan Retribusi Daerah di Kabupaten Badung)

A gradual Tourism development is very important to improve the quality of tourism each year to compete with other tourist attraction. The synergy between the Central Government with local government plays an important role to the development of tourism. The background to this research is the development of tourism which is still insufficient in Labuan Sait both in terms of means and infrastructure, promotion, as well as structuring tourism. This study measures how does tourism development strategy through the synergy with the customary village tourism office on the management of Beach Tourism Labuan Sait in increasing the levy County in Badung Regency with the theory of development that uses the concept of planning development by Sjahrizal in the regional development planning in the era of autonomy. The indicator consists of planning, implementation, monitoring and evaluation. In addition also use the concept of synergy from Najiyati and Rahmat which consists of indicators communication and coordination as well as indicators of the SWOT by Freddy Rangkuti. Method used in this study is a qualitative method with descriptive approach with data collection techniques in the form of in-depth interviews to several informants associated with this research. The results of the research showed that the development strategy of tourism through the synergy with the customary village Tourism Office on the management of Beach Tourism Labuan Sait in improving regional levies in Badung Regency are still insufficient. That is because the is still lacking from the indicator monitoring and implementation and evaluation of the impact against the decline of levy of admission attractions Labuan Sait in the 2017.     Keywords: Development, Tourism, Synergy, and Strateg

Additional file 2: Table S1. of The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment

List of raw and final sequencing results as well as all metadata. (XLSX 2040 kb

Exploring the Biologically Relevant Chemical Space for Drug Discovery

Both recent studies and our calculation suggest that the physicochemical properties of launched drugs changed continuously over the past decades. Besides shifting of commonly used properties, the average biological relevance (BR) and similarity to natural products (NPs) of launched drugs decreased, reflecting the fact that current drug discovery deviated away from NPs. To change the current situation characterized by high investment but low productivity in drug discovery, efforts should be made to improve the BR of the screening library and hunt drugs more effectively in the biologically relevant chemical space. Additionally, a multiple dimensional molecular descriptor, named the biologically relevant spectrum (BRS) was proposed for quantitative structure–activity relationships (QSAR) study or screening library preparation. Prediction models for 43 biological activity categories were developed with BRS and support vector machine (SVM). In most cases, the overall prediction accuracies were around 95% and the Matthew’s correlation coefficients (MCC) were over 0.8. Thirty-seven out of 48 drug-activity associations were successfully predicted for drugs that launched from 2006 to 2012, which were not included in the training data set. A web-server named BioRel (http://ibi.hzau.edu.cn/biorel) was developed to provide services including BR, BRS calculation, activity class, and pharmacokinetic property prediction