2,801 research outputs found
Higgs production at future colliders in the Georgi-Machacek model
We study how the dominant single and double SM-like Higgs () production at
future colliders is modified in the Georgi-Machacek (GM) model. On
imposing theoretical, indirect and direct constraints, significant deviations
of -couplings from their SM values are still possible; for instance, the
Higgs-gauge coupling coupling can be corrected by a factor
in the allowed parameter space. For the
Higgs-strahlung and vector boson fusion processes , the cross section could increase by or decrease
by . In the case of associated production with a top quark pair
, the cross section can be enhanced up to several times
when the custodial triplet scalar is resonantly produced. In the
meanwhile, the double Higgs production can be
maximally enhanced by one order of magnitude at the resonant
production. We also include exclusion limits expected from future LHC runs at
higher energy and luminosity and discuss their further constraints on the
relevant model parameters. We find that the GM model can result in likely
measurable deviations of Higgs production from the SM at future
colliders.Comment: 31 pages, 17 figures, published in JHE
Hunting for Heavy Majorana Neutrinos with Lepton Number Violating Signatures at LHC
The neutrinophilic two-Higgs-doublet model (2HDM) provides a natural way
to generate tiny neutrino mass from interactions with the new doublet scalar
() and singlet neutrinos of TeV scale. In this
paper, we perform detailed simulations for the lepton number violating (LNV)
signatures at LHC arising from cascade decays of the new scalars and neutrinos
with the mass order . Under constraints from lepton
flavor violating processes and direct collider searches, their decay properties
are explored and lead to three types of LNV signatures: , , and . We
find that the same-sign trilepton signature is quite
unique and is the most promising discovery channel at the high-luminosity LHC.
Our analysis also yields the C.L. exclusion limits in the plane of the
and masses at 13 (14) TeV LHC with an integrated luminosity of
100~(3000)/fb.Comment: 31 pages, 17 figures, 6 tables; v2: added a few refs and updated one
ref, without other change
Amending coherence-breaking channels via unitary operations
The coherence-breaking channels play a significant role in quantum
information theory. We study the coherence-breaking channels and give a method
to amend the coherence-breaking channels by applying unitary operations. For
given incoherent channel , we give necessary and sufficient conditions
for the channel to be a coherence-breaking channel and amend it via unitary
operations. For qubit incoherent channels that are not
coherence-breaking ones, we consider the mapping and present
the conditions for coherence-breaking and channel amendment as well.Comment: 8 page
Benzoxime inhibits matrix metalloproteinase-13 activation and cartilage damage in osteoarthritis rats via inhibition of NF-κB pathway
Purpose: To investigate the effect of benzoxime on degradation of articular cartilage in a rat model of osteoarthritis (OA), and the mechanism involved.Methods: The OA rat model was prepared by injecting monosodium iodoacetate (MIA) intra-articularly to Wistar rats. Rats in the treatment group were given benzoxime (5 mg/kg) daily for 21 days through the intra-articular route. The animals were then examined for behavioral changes by assessment of asymmetry in bearing weight and paw withdrawal threshold of the hind limb. Western blot assay was used for the analysis of inflammatory cytokine expressions.Results: The expression of P2X purinoceptor 7 receptor (P2X7R) mRNA was significantly elevated in the OA rats (p < 0.02). However, benzoxime treatment caused a marked decrease in the level of P2X1-8R mRNA. Benzoxime treatment also prevented asymmetry in bearing weight, decreased paw withdrawal threshold, and inhibited the expressions of interleukin-1β, interleukin-6 and tumor necrosis factor-α in plasma and cartilage. Moreover, benzoxime exhibited significant inhibitory effects on the expressions of P2X7R, matrix metalloproteinase (MMP)-13 and prostaglandin E2 (PGE2) in cartilage tissue. It also significantly suppressed OA-induced increases in the levels of inhibitor of nuclear factor-κB (NF-κB) kinase (IKK)α, IKKβ, IκBα and NF-κB p65, and blocked OA-induced increases in the expressions of P2X7R, MMP-13 and PGE2.Conclusion: These results demonstrate that benzoxime prevents cartilage degradation in OA rats by targeting NF-κB signaling pathway. Thus, benzoxime possesses clinical and therapeutic potentials for the prevention of cartilage degradation in OA.Keywords: Interleukin-1β, Purinoceptor-7, Benzoxime, Osteoarthritis, Prostaglandin, Matrix metalloproteinase
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