28 research outputs found
Imaging features of neonatal systemic juvenile xanthogranuloma: A case report and review of the literature
Get PDFJuvenile xanthogranuloma (JXG) is the most common non-Langerhans cell histiocytic disorder in children. This report describes the case of a 28-day-old boy that presented with multiple subcutaneous nodular lesions on the trunk and extremities, and multiple red nodular lesions on the scrotum. Magnetic resonance imaging (MRI) of the brain showed a well-demarcated extra-axial dura-based mass that appeared isointense or slightly hyperintense on T1-weighted images, hypointense on T2-weighted images and had intense enhancement on gadolinium-enhanced T1-weighted images. Computed tomography (CT) or MRI scans of the chest and abdomen revealed multiple scattered nodular or patchy lesions of varying sizes in the lungs, liver and left kidney. Histological analysis of a subcutaneous mass suggested JXG. The patient was diagnosed with neonatal systemic JXG with involvement of the central nervous system, lungs, liver, kidneys, subcutaneous soft tissue and skin. CT and MRI after 3 months of treatment with methylprednisolone sodium succinate demonstrated that the lesions were obviously diminished. This report discusses the imaging findings in this current case of multi-organ JXG and reviews the imaging literature on this condition to improve awareness of the lesions in order to help radiologists establish an accurate differential diagnosis when confronted with similar cases
Ozone affects plant, insect, and soil microbial communities: a threat to terrestrial ecosystems and biodiversity
Get PDFElevated tropospheric ozone concentrations induce adverse effects in plants. We reviewed how ozone affects (i) the composition and diversity of plant communities by affecting key physiological traits; (ii) foliar chemistry and the emission of volatiles, thereby affecting plant-plant competition, plant-insect interactions, and the composition of insect communities; and (iii) plant-soil-microbe interactions and the composition of soil communities by disrupting plant litterfall and altering root exudation, soil enzymatic activities, decomposition, and nutrient cycling. The community composition of soil microbes is consequently changed, and alpha diversity is often reduced. The effects depend on the environment and vary across space and time. We suggest that Atlantic islands in the Northern Hemisphere, the Mediterranean Basin, equatorial Africa, Ethiopia, the Indian coastline, the Himalayan region, southern Asia, and Japan have high endemic richness at high ozone risk by 2100
Effects of acute moderate-intensity exercise at different duration on blood pressure and endothelial function in young male patients with stage 1 hypertension
No full textPurpose The studies regarding the effects of exercise duration on blood pressure have reported inconsistent and conflicting results. Nitric oxide (NO) is a well-known vasodilator released by endothelial cells, and endothelial microparticles (EMPs) are membranous vesicles released into the circulation from activated or apoptotic endothelial cells, both of whose level can reflect the endothelial function. But few studies have been done to explore the effect of exercise duration on blood pressure and endothelial function, especially, the EMPs response to exercise in young male patients with hypertension. This study aimed to investigate the blood pressure response during moderate-intensity exercise performed in different durations and the acute effects on post-exercise hypotension and endothelial function in hypertensive patients. Methods Eighteen young male hypertensive patients who did not take antihypertensive drugs were recruited in this study. They randomly performed twice exercises on a cycle ergometer at a moderate intensity of 40%–50% of their HR reserve; one was 20 min (E20 session), the other one was 40 min (E40 session); there was 1-week break between the two exercises. Blood pressure was monitored by the YUWELL blood pressure monitor at rest, every 5 min during exercise, and 3 and 6 min post-exercise. The level of NO (nitrate/nitrite reduction) and EMPs (flow cytometry) in plasma were detected before and immediately following exercise. CD31+/CD42b− events were classified as EMPs and events per microliter plasma were calculated. This study was approved by the Beijing Sport University Institutional Review Board (protocol number 2019087 H). Results Mean age of patients was 34.8 ± 3.5 yrs, and BMI was 27.6 ± 2.7 kg/m2. Systolic blood pressure (SBP) in the two sessions increased significantly during exercise. The SBP in the E20 session increased by 37 mmHg (P < .01) at 5 min during exercise and remained stable afterward. In the E40 session, the SBP increased by 35 mmHg (P < .01) at 5 min during exercise and was stable at 5 through 25 min, decreased by 8 mmHg at 25 through 35 min during exercise, and then stabilized (P < .01). There was no obvious change of diastolic blood pressure (DBP) in the two sessions during exercise. In the E20 session, SBP at 6 min following exercise was no different from the rest; in the E40 session, SBP at 6 min following exercise was 14 mmHg lower than at the rest (P < .01). DBP in the E20 session was the same as rest at 3 min following exercise and decreased by 4 mmHg at 6 min following exercise compared with the rest (P < .05), while DBP in the E40 session decreased by 3 mmHg at 3 min following exercise compared with the rest (P < .05). The plasma NO levels of E20 and E40 increased significantly following exercise (P < .01 for both). There was no difference in plasma NO level between the two sessions pre- and post-exercise, but the increased magnitude of NO level in E40 was greater than that in E20 (24.47% vs. 9.24%, P < .01). The plasma EMPs level of E20 and E40 decreased significantly following exercise (P < .01 for both). There was no difference in plasma EMPs level between the two sessions pre- and post-exercise, but the decreased magnitude of EMPs level in E40 was greater than that in E20 (15.66% vs. 8.00%, P < .01). Conclusion There is no exaggerated blood pressure response to 20-min and 40-min acute moderate-intensity exercise in young hypertensive men with no antihypertensive drugs. Both 20-min and 40-min acute moderate exercise can reduce the rest blood pressure, and improve endothelial function by increasing NO and decreasing EMPs in young male patients with hypertension, and the effects of 40-min exercise on lowering SBP and improving endothelial function are better than that of 20-min
Large Scale Model Test Study of Foundation Pit Supported by Pile Anchors
No full textDue to the special time–space and environmental effects of the foundation pit, there are many unstable factors in the construction process of the field test. The indoor model test can avoid many uncertainties in the construction process due to its operability, which can reduce the interference with the test results and improve the accuracy of the test. In order to further discuss the force-bearing characteristics and deformation laws of loess pits’ support structure in Northwest China, a large model test of foundation pit supported by a pile anchor with a geometric similarity ratio of 1:10 was designed and completed. The force and deformation characteristics of the support structure were systematically studied by simulating the conditions of additional load at the pit edge, soil layered excavated, and anchors tensioned. The test results show that: for the pile-anchor support structure, the anchors have significant limiting effects on the displacement of the piles. Especially, when the position of the first row of anchors is closer to the pile top, the displacement of the pile is smaller. The stress state of the piles was changed by the prestressed anchor. The passive stress state of piles is changed from one side of tension and the other side of compression to the active stress state of “S” shape, which makes the distribution of the bending moment of piles more reasonable. The measured earth pressure in the process of soil unloading has a nonlinear distribution, which is different from the classical Rankine earth pressure distribution; specifically, the passive earth pressure in front of the pile is more obvious. In addition, the prestress applied to the anchors has a more significant effect on the internal forces of the other anchors. Compared with sequential tensioning, the prestress loss caused by interval hole tensioning is significantly reduced. The greater the number of spaced holes, the smaller the prestress loss and the better the anchoring effect of the anchor. The results of the study can provide reference for similar model tests, and also for related engineering applications
Large Scale Model Test Study of Foundation Pit Supported by Pile Anchors
No full textDue to the special time–space and environmental effects of the foundation pit, there are many unstable factors in the construction process of the field test. The indoor model test can avoid many uncertainties in the construction process due to its operability, which can reduce the interference with the test results and improve the accuracy of the test. In order to further discuss the force-bearing characteristics and deformation laws of loess pits’ support structure in Northwest China, a large model test of foundation pit supported by a pile anchor with a geometric similarity ratio of 1:10 was designed and completed. The force and deformation characteristics of the support structure were systematically studied by simulating the conditions of additional load at the pit edge, soil layered excavated, and anchors tensioned. The test results show that: for the pile-anchor support structure, the anchors have significant limiting effects on the displacement of the piles. Especially, when the position of the first row of anchors is closer to the pile top, the displacement of the pile is smaller. The stress state of the piles was changed by the prestressed anchor. The passive stress state of piles is changed from one side of tension and the other side of compression to the active stress state of “S” shape, which makes the distribution of the bending moment of piles more reasonable. The measured earth pressure in the process of soil unloading has a nonlinear distribution, which is different from the classical Rankine earth pressure distribution; specifically, the passive earth pressure in front of the pile is more obvious. In addition, the prestress applied to the anchors has a more significant effect on the internal forces of the other anchors. Compared with sequential tensioning, the prestress loss caused by interval hole tensioning is significantly reduced. The greater the number of spaced holes, the smaller the prestress loss and the better the anchoring effect of the anchor. The results of the study can provide reference for similar model tests, and also for related engineering applications
Secular change in cardiorespiratory fitness and body composition of women: The aerobics center longitudinal study
No full textTo investigate secular change of cardiorespiratory fitness (CRF) and body composition during 35 years in a large sample of women enrolled in the Aerobics Center Longitudinal Study.A cross-sectional analysis of baseline fitness data collected during preventive medical examination of 13,037 women aged 20 to 64 years evaluated at the Cooper Clinic in Dallas, Texas, from January 1, 1970, through December 30, 2004, who underwent a body composition assessment and a maximal treadmill exercise test. Women were stratified by examination year (5 years for each group) and age. Analysis of covariance was used to ascertain secular change of CRF and body composition.Adjusted CRF levels, as indicated by maximal metabolic equivalent or relative maximum oxygen consumption, among women in the cohort increased significantly during a 35-year period for both age groups (
Normal References of Peak Oxygen Uptake for Cardiorespiratory Fitness Measured with Cardiopulmonary Exercise Testing in Chinese Adults
No full textIntroduction: This study aims to establish normal reference values of peak oxygen uptake (VO2peak) for cardiorespiratory fitness (CRF) in Chinese adults using cardiorespiratory exercise testing (CPET). Methods: A cross-sectional study was done in four communities, two in the North (Beijing) and two in the South (Hezhou, Guangxi) of China from 1 January 2017 to 31 December 2018, with one urban and one rural in each region. Out of 1642 participants screened, 1114 were eligible and completed CPET using a cycle ergometer (Ergosana320F) without abnormal ECG and were included in the analysis. The 2nd and 98th percentiles of V·O2peak were used as the lower and upper limits of the normal reference values. Results: Significant difference in mean V·O2peak was shown between men (27.0 mL·min−1·kg−1) and women (23.7 mL·min−1·kg−1). The mean V·O2peak decreased with age in both sexes, from 35.8 mL·min−1·kg−1 in age 20–29 years to 20.5 mL·min−1·kg−1 in 70–79 years in men and from 29.2 mL·min−1·kg−1 to 17.0 mL·min−1·kg−1 in women. Thus, the age- and sex-specific normal reference values of V·O2peak were presented for each 10-year age group by men and women separately. Conclusions: This first community-based study in China provides age- and sex-specific normal references of V·O2peak as a measure of CRF in Chinese adults, which differed significantly from those established in Western populations. Future studies with national representative samples should be warranted
A case study on the bearing characteristics of a bottom uplift pile in a layered foundation
No full textAbstract The bottom uplift pile, which has been applied in practical projects, has the following advantages: the pile body is not easy to crack, good bearing characteristics, and small displacement of the pile top. Based on the bearing capacity test of foundation piles in the third stage expansion project of Lanzhou Zhongchuan International Airport, the upper part pile of the self-balancing test method was used to simulate the bottom uplift pile, and the anchor piles in the anchor pile method were regarded as normal uplift piles. The bearing characteristics of the bottom uplift pile in a layered foundation were studied by comparing these two kinds of piles. The results show that under the same displacement of the pile top, the ultimate uplift bearing capacity of the bottom uplift pile can be more than twice that of the normal uplift pile because of the fully exerted frictional resistance of the soil at the bottom of the pile, the Poisson effect of the pile body and the avoidance of the influence of pile body deformation on the pile top displacement. The maximum axial force of the bottom uplift pile appears at the bottom of the pile and gradually decreases from the bottom to the top, which is opposite to that of the normal uplift pile. The properties and thickness of the soil layers around the pile have a great influence on the distribution curves of the frictional resistance along the pile length of the two kinds of uplift piles. With changing soil layer conditions, the distribution curve may be a "parabola", a "straight line" or a "double line". The soil property plays a decisive role in the frictional resistance, which may cause softening. The influence of the pile diameter on the ultimate uplift bearing capacity is greater than that of the pile length, while the elastic modulus of the pile has little influence
Design and Field Monitoring of a Pile–Anchor–Brace Supporting System in a Soft Soil Area
No full textWith the continuous development of urbanization and the rapid development of science and technology, the requirements for foundation pit engineering are getting higher and higher. Foundation pit engineering is gradually developing in the direction of larger area and deeper excavation. In engineering examples, the combined supporting structure of a pile–brace and pile–anchor for foundation pits is widely used, while the engineering examples supported by a pile–anchor–brace supporting system are less frequently used. Based on a super-large deep foundation pit project in Yancheng City, Jiangsu Province, China, according to the surrounding environmental conditions, the foundation pit support scheme, and on-site construction situation, the design and on-site monitoring of the pile–anchor–brace supporting system were introduced and analyzed. The results show that: (1) the deformation of the pile–anchor–brace supporting system shows an obvious spatial effect, and the horizontal displacement of the pile and soil of the long side direction is greater than the short side direction; (2) in the initial state, the deep horizontal displacement of the soil is in the form of a ‘cantilever’, but in the later stage it changed to the form of a ‘drum belly’, and both the brace and anchor cable can limit the displacement of the soil effectively; (3) the axial force of the brace develops rapidly in the initial stage, but its development tends to be gentle after the completion of the first anchor cable construction. Through on-site monitoring, it was found that the axial force of the ring brace was larger than that of the corner brace, which was larger than the opposite brace; and (4) the development trend of the axial force for the two rows of anchor cables is quite different. The average axial force of the first row of anchor cables is greater than the second row of anchor cables, and the development trend of the first row of anchor cables is steep first and then gentle, while the change trend of the second row of anchor cables is just the opposite
