Dynamic Context-guided Capsule Network for Multimodal Machine Translation

Multimodal machine translation (MMT), which mainly focuses on enhancing text-only translation with visual features, has attracted considerable attention from both computer vision and natural language processing communities. Most current MMT models resort to attention mechanism, global context modeling or multimodal joint representation learning to utilize visual features. However, the attention mechanism lacks sufficient semantic interactions between modalities while the other two provide fixed visual context, which is unsuitable for modeling the observed variability when generating translation. To address the above issues, in this paper, we propose a novel Dynamic Context-guided Capsule Network (DCCN) for MMT. Specifically, at each timestep of decoding, we first employ the conventional source-target attention to produce a timestep-specific source-side context vector. Next, DCCN takes this vector as input and uses it to guide the iterative extraction of related visual features via a context-guided dynamic routing mechanism. Particularly, we represent the input image with global and regional visual features, we introduce two parallel DCCNs to model multimodal context vectors with visual features at different granularities. Finally, we obtain two multimodal context vectors, which are fused and incorporated into the decoder for the prediction of the target word. Experimental results on the Multi30K dataset of English-to-German and English-to-French translation demonstrate the superiority of DCCN. Our code is available on https://github.com/DeepLearnXMU/MM-DCCN

Androgen Regulation of 5α-Reductase Isoenzymes in Prostate Cancer: Implications for Prostate Cancer Prevention

The enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key functions in the androgen receptor (AR) signaling pathway. The three isoenzymes of 5α-reductase identified to date are encoded by different genes: SRD5A1, SRD5A2, and SRD5A3. In this study, we investigated mechanisms underlying androgen regulation of 5α-reductase isoenzyme expression in human prostate cells. We found that androgen regulates the mRNA level of 5α-reductase isoenzymes in a cell type–specific manner, that such regulation occurs at the transcriptional level, and that AR is necessary for this regulation. In addition, our results suggest that AR is recruited to a negative androgen response element (nARE) on the promoter of SRD5A3 in vivo and directly binds to the nARE in vitro. The different expression levels of 5α-reductase isoenzymes may confer response or resistance to 5α-reductase inhibitors and thus may have importance in prostate cancer prevention

Effect of Mo/Nb ratio variations on the microstructure and cryogenic impact toughness of NiCrMo deposited metals

Effects of varying the Mo/Nb (in weight percent) ratio in ENiCrMo-6-deposited metals on the microstructure and cryogenic impact toughness of the metals were investigated. When the Mo/Nb ratio decreased from 6.09 to 3.28, the Nb-rich phase on the grain boundaries was transformed from un-continuous precipitation to continuous precipitation, the area fraction and average size of the precipitates within the grains were significantly increased, and a eutectic-type Laves phase appeared. Although the austenitic matrix of the deposited metals indicated a ductile fracture mode, the precipitates significantly deteriorated the cryogenic impact toughness. As the average size and area fraction of the precipitates increased, the cryogenic impact value decreased significantly

Stability of Impulsive Neural Networks with Time-Varying and Distributed Delays

This work is devoted to investigating the stability of impulsive cellular neural networks with time-varying and distributed delays. We use the new method of fixed point theory to obtain some new and concise sufficient conditions to ensure the existence and uniqueness of solution and the global exponential stability of trivial equilibrium. The presented algebraic criteria are easily checked and do not require the differentiability of delays

Effects of residual mulching films with different mulching years on the diversity of soil microbial communities in typical regions

Polyethylene mulching film plays a critical role in agricultural production. To clarify the impact of residual film and microplastics on soil microorganisms, this study examined four cotton fields with different film coverage years in typical areas of Xinjiang and analyzed the changes in soil bacterial and fungal community structure and diversity under residual film and microplastics using high-throughput sequencing technology. The results showed that the residual film in the 0–150 mm soil layers and 150–300 mm soil layers at the same sampling point had spatial distribution characteristics of 60–70% and 30–40%, respectively. The short period of the 0–10 years film mulching treatment increased the soil microbial diversity of the cotton field, whereas continuous film mulching for 25 years significantly decreased the soil microbial diversity, in which Proteobacteria was the dominant bacterial phylum and Ascomycetes was the dominant fungal phylum. The microbial diversity of the film-covered soil was lower than that of the control group. The spatial distribution of the residual film and microplastic changed the distribution of the microbial communities. The diversity of the microbial community structure of the 0–150 mm soil layers was higher than that of the 150–300 mm soil layers. The increase in residual film and microplastics had no significant effect on the diversity of the fungal community but decreased the diversity of the soil bacterial community and decreased the relative abundance of Proteobacteria and Campylobacter. In conclusion, long-term film mulching reduced the soil microbial diversity in cotton fields. This study provides a theoretical basis for understanding the impact of film residues on microorganisms and the ecological environment in typical areas

Additional file 2: Table S2. of Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions

Presenting sterility and pathogen testing in the two clinical-grade hiPSC lines. (DOC 33 kb