Hashing technique to optimally balance load within switching networks

Network protocols use multiple paths to route packets between network nodes, such that network capacity is optimally utilized in a scalable manner. Equal cost multipath (ECMP) and weighted cost multipath (WCMP) are routing techniques to balance load across multiple paths between traffic source and destination. Load balancing is typically achieved using a hash function to select the next hop for flows of balanced size. Hash functions are provided by switch hardware, and there is often only a limited number of uncorrelated hash functions. Reuse of correlated hash functions can lead to imbalanced traffic distribution within the network. The present disclosure describes techniques to balance traffic distribution within a network by use of VLAN (virtual local area network) tags as a hash input and by shuffling VLAN tags of packets at switches along a path

Epidemiology and associations with climatic conditions of Mycoplasma pneumoniae and Chlamydophila pneumoniae infections among Chinese children hospitalized with acute respiratory infections

BACKGROUND: The incidence of severe acute respiratory tract infections in children caused by Mycoplasma pneumoniae (syn. Schizoplasma pneumoniae) and Chlamydophila pneumoniae (formerly Chlamydia pneumoniae) varies greatly from year to year and place to place around the world. This study investigated the epidemiology of M. pneumoniae and C. pneumoniae infections among children hospitalized with acute respiratory infections in Suzhou, China in the year 2006, and associations between incidence rates and climatic conditions. METHODS: Nasopharyngeal aspirates obtained from 1598 patients (aged 26.4 ± 28.3 months; range, 1 month to 13 years) were analyzed with real-time PCR and ELISA. Meteorological data were obtained from the weather bureau. RESULTS: About 18.5% of patients were infected with M. pneumoniae and, C. pneumoniae, or both. Isolated M. pneumoniae infection was positively correlated with increasing age (χ(2) = 34.76, P < 0.0001). Incidence of M. pneumoniae infection was seasonal with a peak in summer (P < 0.0001) and minimum in winter (P = 0.0001), whereas C. pneumoniae infection was low only in autumn (P = 0.02). Monthly mean temperature was strongly correlated with the incidence of M. pneumoniae infection (r = 0.825, P = 0.001). CONCLUSIONS: M. pneumoniae and C. pneumoniae are important infectious agents in hospitalized children with acute respiratory tract infections. M. pneumoniae infection showed a strong direct correlation with environmental temperature

Over-expression of human cytomegalovirus miR-US25-2-3p downregulates eIF4A1 and inhibits HCMV replication

AbstractIt has been reported that human cytomegalovirus (HCMV) miR-US25-2 reduces DNA viral replication including HCMV. However, the mechanism remains unknown. In our study, eukaryotic translation initiation factor 4A1 (eIF4A1) was identified to be a direct target of miR-US25-2-3p. Small interfering RNA (siRNA) and miR-US25-2-3p mediated eIF4A1 knockdown experiments revealed that high level of miR-US25-2-3p in MRC-5 cells decreased HCMV and host genomic DNA synthesis, and inhibited cap-dependent translation and host cell proliferation. However, eIF4A1 up-regulation induced by miR-US25-2-3p inhibitor increased HCMV copy number. Therefore, the over-expression of miR-US25-2-3p and consequent lower expression of eIF4A1 may contribute to the inhibition of HCMV replication

Characterization of the transcripts of human cytomegalovirus UL144

<p>Abstract</p> <p>Background</p> <p>The genome of human cytomegalovirus (HCMV) has been studied extensively, particularly in the UL/b' region. In this study, transcripts of one of the UL/b' genes, UL144, were identified in 3 HCMV isolates obtained from urine samples of congenitally infected infants.</p> <p>Methods</p> <p>Northern blot hybridization, cDNA library screening, and RACE-PCR were used.</p> <p>Results</p> <p>We identified at least 4 differentially regulated 3'-coterminal transcripts of UL144 in infected cells of 1,300, 1,600, 1,700, and 3,500 nucleotides (nt). The 1600 nt transcript was the major form of UL144 mRNA. The largest transcript initiated from the region within the UL141 open reading frame (ORF) and included UL141, UL142, UL143, UL144, and UL145 ORFs.</p> <p>Conclusions</p> <p>These findings reveal the complex nature of the transcription of the UL144 gene in clinical isolates.</p

Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia

Supporting data. (XLS 58 kb

New Measles Virus Genotype Associated with Outbreak, China

Better understanding of transmission patterns will enhance control and elimination programs

Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years

The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%–100% and 84.7%–100%, H1b were 97.1%–100% and 95.3%–100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years

TWINE: A Hybrid Emulation Testbed for Wireless Networks and Applications

In this paper, we present a high fidelity and efficient emulation framework called TWINE, which combines the accuracy and realism of emulated and physical networks and the scalability and repeatability of simulation in an integrated testbed, for evaluation of real protocols and applications. Our measurements show that the TWINE emulation kernel has a memory footprint of less than 100KB, and occupies no more than 3.5 % CPU cycles. Thanks to such small overhead and the accurate modelling of physical layer events(at microseconds level), application throughput measured in TWINE is within 5 % of the measured throughput from an equivalent physical wireless LAN. A single commodity PC in TWINE can emulate at least four wireless hosts or simulate sixty nodes in real time at microseconds granularity. This paper also illustrates TWINE’s novel capabilities via two case studies: a protocol to maintain fairness in mesh networks and an adaptive streaming media application operating in heterogeneous wireless networks. The results from the case studies clearly show the benefit of the TWINE evaluation methodology, by identifying a mismatch between the performance of the protocol or application based on actual user experience versus its performance as measured using traditional network performance metrics such as application throughput. 1