Nine radiation components observed at the Shangdianzi regional GAW station in China (2013-2022)

This dataset consists of quality-assured daily data of nine radiation components (i.e., global shortwave irradiance, direct shortwave irradiance, diffuse shortwave irradiance, upwelling shortwave irradiance, photosyntheticall active radiation, ultraviolet A irradiance, ultraviolet B irradiance, downwelling longwave irradiance, and upwelling longwave irradiance) observed at the Shangdianzi regional GAW station (40.65°N, 117.12°E; 293.3 m a.s.l.) in China during 2013–2022. A Hybrid Algorithm for Radiation Data Quality Control (HARDQC) algorithm is performed on all radiation data to guarantee the highest quality of the dataset. The dataset can be applied in many fields such as the validation of satellite products and numerical models, investigation of relationships between radiation and atmospheric composition, and the detection of changes in the surface fluxes

Aiolos Promotes Anchorage Independence by Silencing p66Shc Transcription in Cancer Cells

SummaryAnchorage of tissue cells to their physical environment is an obligate requirement for survival that is lost in mature hematopoietic and in transformed epithelial cells. Here we find that a lymphocyte lineage-restricted transcription factor, Aiolos, is frequently expressed in lung cancers and predicts markedly reduced patient survival. Aiolos decreases expression of a large set of adhesion-related genes, disrupting cell-cell and cell-matrix interactions. Aiolos also reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66Shc and blocking anoikis in vitro and in vivo. In lung cancer tissues and single cells, p66Shc expression inversely correlates with that of Aiolos. Together, these findings suggest that Aiolos functions as an epigenetic driver of lymphocyte mimicry in metastatic epithelial cancers