Many-body Chemical Reactions in a Quantum Degenerate Gas

Chemical reactions in the quantum degenerate regime are described by mixing of matterwave fields. Quantum coherence and bosonic enhancement are two unique features of many-body reactions involving bosonic reactants and products. Such collective reactions of chemicals, dubbed "super-chemistry", is an elusive goal in quantum chemistry research. Here we report the observation of coherent and collective reactive coupling between Bose condensed atoms and molecules near a Feshbach resonance. Starting from an atomic condensate, the reaction begins with a rapid formation of molecules, followed by oscillations of their populations in the equilibration process. Faster oscillations are observed in samples with higher densities, indicating bosonic enhancement. We present a quantum field model which describes the dynamics well and identifies three-body recombination as the dominant reaction process. Our findings exemplify the highly sought-after quantum many-body chemistry and offer a new paradigm for the control of quantum chemical reactions.Comment: 15 pages, 10 figures. Nat. Phys. (2023

Scheme Design for Communication between Network Port and Serial Port Based on ARM

Abstract. The data transmission scheme between a transmission control protocol/internet protocol (TCP/IP) network port and a serial port based on an ARM embedded system is introduced in the paper. The data transmission between a personal computer (PC) and remote equipment through an Internet is realized. The structure of a hardware platform is simply introduced, the cutting and transplant of operating system, the communication program design of the network port and the serial port and the cross compiling between the two ports are introduced in detail. The AT91SAM9261 chip of ATMEL Corporation is employed as the embedded board of a kernel processor. The Redhat9 Linux operating system is employed as a software development platform, an ARM-Linux operating system is employed as a program operation platform and the kernel version is Linux-2.6.2. The C program is used and an ARM-Linux-GNU tool chain is used for the cross compiling. The experimental result proves that the real-time, parallel full duplex data transmission between the network port and the serial port is realized by the scheme provided in the paper

Scheme Design for Communication between Network Port and Serial Port Based on ARM

Abstract. The data transmission scheme between a transmission control protocol/internet protocol (TCP/IP) network port and a serial port based on an ARM embedded system is introduced in the paper. The data transmission between a personal computer (PC) and remote equipment through an Internet is realized. The structure of a hardware platform is simply introduced, the cutting and transplant of operating system, the communication program design of the network port and the serial port and the cross compiling between the two ports are introduced in detail. The AT91SAM9261 chip of ATMEL Corporation is employed as the embedded board of a kernel processor. The Redhat9 Linux operating system is employed as a software development platform, an ARM-Linux operating system is employed as a program operation platform and the kernel version is Linux-2.6.2. The C program is used and an ARM-Linux-GNU tool chain is used for the cross compiling. The experimental result proves that the real-time, parallel full duplex data transmission between the network port and the serial port is realized by the scheme provided in the paper

Aspirin Inhibits Natural Killer/T-Cell Lymphoma by Modulation of VEGF Expression and Mitochondrial Function

Extranodal nasal-type natural killer/T-cell lymphoma (NKTCL) is an Epstein-Barr virus (EBV)-associated lymphoma with a strong tendency relapse or be refractory in response to chemotherapy. Development of a new strategy for NKTCL treatment is still quite necessary. In this study, we found that aspirin treatment suppresses VEGF expression in NKTCL SNK-6 cells. Further investigation showed that aspirin treatment increases histone methylation in the range of −100~0 that is proximal to the transcription start site on the VEGF promoter, subsequently decreasing the binding ability of Sp1 to the VEGF promoter with VEGF suppression. Furthermore, aspirin treatment modulates mitochondrial function with increased ROS formation and apoptosis in NKTCL cells. Aspirin treatment alone slightly inhibits NKTCL SNK-6 tumor growth and EBV replication; while in the presence of histone deacetylase inhibitor (HDACi) chidamide (CDM), aspirin significantly suppresses the VEGF signaling pathway with increased ROS overgeneration and EBV inhibition. We also showed that with the addition of chidamide, aspirin significantly suppresses NKTCL tumor growth in both in vitro cell culture and in vivo mouse model with prolonged mouse survival. This is the first time that the potential mechanism for aspirin-mediated VEGF suppression and anti-tumor effect has been discovered, and this study provides a new strategy for anti-tumor drug development for NKTCL treatment based on aspirin-mediated targeting of the VEGF signaling pathway and ROS formation

PGC1β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression

Background: Breast cancer is a very common cancer with significant premature mortality in women. In this study, we show that HKDC1 expression in breast cancer cells is increased significantly. We aim to investigate the detailed mechanism for the regulation of HKDC1 expression and its potential contribution to tumorigenesis.Methods: Gene expression was evaluated by real time PCR, western blotting, and immunohistochemistry. The mechanism for PGC1β/SREBP1-mediated HKDC1 expression was investigated using luciferase reporter assay, chromatin immunoprecipitation, and siRNA techniques. In addition, HKDC1 was overexpressed or knocked down by lentivirus to evaluate the potential effect on in vitro cell proliferation, glucose uptake, mitochondrial function, apoptosis, and reactive oxygen species (ROS) formation. Furthermore, an in vivo xenograft tumor development study was employed to investigate the effect of HKDC1 on tumor growth and mouse survival.Results: HKDC1 is highly expressed in both breast cancer cells and clinical tumor tissues. HKDC1 expression is upregulated and co-activated by PGC1β through SREBP1 binding motif on the HKDC1 promoter. HKDC1 is located on the mitochondrial membrane and regulates the permeability transition pore opening by binding with VDAC1, subsequently modulating glucose uptake and cell proliferation. Overexpression of HKDC1 increases while knockdown of HKDC1 decreases in vitro breast cancer cell proliferation and in vivo tumor growth, metastasis, and mouse survival.Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment

Thermal induced spin-polarized current protected by spin-momentum locking in nanowires

Spin-momentum locking arising from strong spin-orbit coupling is one of the key natures of topological materials. Since charge can induce a spin polarization due to spin-momentum locking, the search for materials that exhibit this feature has become one of the top priorities in the field of spintronics. In this paper, we report the electrical detection of the spin-transport properties of nanowires, using a nonlocal geometry measurement. A clear hysteresis voltage signal, which depends on the relative orientations between the magnetization of the ferromagnetic electrodes and the carrier spin polarization, has been observed. The hysteresis voltage states can be reversed by altering the electron movement direction, providing direct evidence of the spin-momentum locking feature of nanowires and revealing its topological nature. Furthermore, the current-dependent measurement suggests that the charge (spin) current is induced by thermal effect, which utilizes the thermoelectric properties of . Using the thermal effect to control the spin-polarized current protected by spin-momentum locking offers possibilities for small-sized devices based on the topological materials