Etalon Array Reconstructive Spectrometry.

Compact spectrometers are crucial in areas where size and weight may need to be minimized. These types of spectrometers often contain no moving parts, which makes for an instrument that can be highly durable. With the recent proliferation in low-cost and high-resolution cameras, camera-based spectrometry methods have the potential to make portable spectrometers small, ubiquitous, and cheap. Here, we demonstrate a novel method for compact spectrometry that uses an array of etalons to perform spectral encoding, and uses a reconstruction algorithm to recover the incident spectrum. This spectrometer has the unique capability for both high resolution and a large working bandwidth without sacrificing sensitivity, and we anticipate that its simplicity makes it an excellent candidate whenever a compact, robust, and flexible spectrometry solution is needed

The H

The existence of global weak solutions to the Cauchy problem for a generalized Camassa-Holm equation with a dissipative term is investigated in the space C([0,∞) × R)∩L∞([0,∞); H1(R)) provided that its initial value u0(x) belongs to the space H1(R). A one-sided super bound estimate and a space-time higher-norm estimate on the first-order derivatives of the solution with respect to the space variable are derived

Three-dimensional fluorescent microscopy via simultaneous illumination and detection at multiple planes.

The conventional optical microscope is an inherently two-dimensional (2D) imaging tool. The objective lens, eyepiece and image sensor are all designed to capture light emitted from a 2D 'object plane'. Existing technologies, such as confocal or light sheet fluorescence microscopy have to utilize mechanical scanning, a time-multiplexing process, to capture a 3D image. In this paper, we present a 3D optical microscopy method based upon simultaneously illuminating and detecting multiple focal planes. This is implemented by adding two diffractive optical elements to modify the illumination and detection optics. We demonstrate that the image quality of this technique is comparable to conventional light sheet fluorescent microscopy with the advantage of the simultaneous imaging of multiple axial planes and reduced number of scans required to image the whole sample volume

Coupled effects of moisture transport pathway and convection on stable isotopes in precipitation across the East Asian Monsoon Region: implications for paleoclimate reconstruction

This study investigated the variations in stable oxygen isotopes in daily precipitation (δ18Op) collected between 2010 and 2013 at four sites across the East Asian monsoon region to address the controversy whether local meteorological factors, moisture transport pathway, or convection dominates the δ18Op changes. We found that the δ18Op time series exhibit opposite seasonal patterns between the southern and northern sites; however, relatively low δ18Op values occur at each site during summer. The opposite seasonal patterns are closely related to the proportional change in the contributions from oceanic (>52% in the south) and continental (>85% in the north) moisture sources. Moisture transport distances also influence the seasonal δ18Op fluctuations. In the south, the moisture transported over short distances from the middle of the western Pacific Ocean results in relatively high δ18Op values during the premonsoon season. In contrast, long-distance transport of moisture from the Indian and equatorial Pacific Oceans during the monsoon season results in relatively low δ18Op values. In the north, relatively low δ18Op values during the monsoon season can be attributed to an increase in relatively distant moisture originating from the middle of the western Pacific Ocean. Convection only plays a role in affecting δ18Op values in the south during the monsoon season. Our study suggests that moisture transport pathway (moisture sources and moisture transport distances) is a major factor that governs seasonal variations in δ18Op across the East Asian monsoon region, which has implications for the interpretation of paleoclimate records from this region

Array atomic force microscopy for real-time multiparametric analysis.

Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale biological and physical systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. Conventional AFMs only permit sequential single-point analysis; widespread adoption of array AFMs for simultaneous multipoint study is challenging owing to the intrinsic limitations of existing technological approaches. Here, we describe a prototype dispersive optics-based array AFM capable of simultaneously monitoring multiple probe-sample interactions. A single supercontinuum laser beam is utilized to spatially and spectrally map multiple cantilevers, to isolate and record beam deflection from individual cantilevers using distinct wavelength selection. This design provides a remarkably simplified yet effective solution to overcome the optical cross-talk while maintaining subnanometer sensitivity and compatibility with probe-based sensors. We demonstrate the versatility and robustness of our system on parallel multiparametric imaging at multiscale levels ranging from surface morphology to hydrophobicity and electric potential mapping in both air and liquid, mechanical wave propagation in polymeric films, and the dynamics of living cells. This multiparametric, multiscale approach provides opportunities for studying the emergent properties of atomic-scale mechanical and physicochemical interactions in a wide range of physical and biological networks

Traffic conflict identification of e-bikes at signalized intersections

The increase of e-bikes has raised traffic conflict concerns over past decade. Numerous conflict indicators are applied to measure traffic conflicts by detecting differences in temporal or spatial proximity between users. However, for traffic environment with plenty of e-bikes, these separate space-time approaching indicators may not be applicable. Thus, this study aims to propose a multi-variable conflict indicator and build a conflict identification method for e-bikes moving in the same direction. In particular, by analysing the conflict characteristics from e-bikes trajectories, a multi-variable conflict indicator utilizing change of forecast post encroachment time, change of relative speed and change of distance is derived. Mathematical statistics and cluster discriminant analyses are applied to identify types of conflict, including conflict existence identification and conflict severity identification. The experimental results show: in mixed traffic environments with many e-bikes, compared with time-to-collision and deceleration, accuracy of identifying e-bike conflict types based on proposed method is the highest and can reach more than 90%; that is, multi-variable indicator based on time and space are more suitable for identifying e-bike conflicts than separate space-time approaching indicators. Furthermore, setting of dividing strip between motor vehicle and non-motorized vehicle has significant influence on number and change trend of conflict types. The proposed method can not only provide a theoretical basis and technical support for automated conflict detection in mixed transportation, but also give the safety optimization sequence of e-bikes at different types of intersections. First published online 22 October 202

Inverse altitude effect disputes the theoretical foundation of stable isotope paleoaltimetry

Stable isotope paleoaltimetry that reconstructs paleoelevation requires stable isotope (δD or δ18O) values to follow the altitude effect. Some studies found that the δD or δ18O values of surface isotopic carriers in some regions increase with increasing altitude, which is defined as an “inverse altitude effect” (IAE). The IAE directly contradicts the basic theory of stable isotope paleoaltimetry. However, the causes of the IAE remain unclear. Here, we explore the mechanisms of the IAE from an atmospheric circulation perspective using δD in water vapor on a global scale. We find that two processes cause the IAE: (1) the supply of moisture with higher isotopic values from distant source regions, and (2) intense lateral mixing between the lower and mid-troposphere along the moisture transport pathway. Therefore, we caution that the influences of those two processes need careful consideration for different mountain uplift stages before using stable isotope palaeoaltimetry

Higher adjuvant radioactive iodine therapy dosage helps intermediate-risk papillary thyroid carcinoma patients achieve better therapeutic effect

ObjectiveThis retrospective study aims to evaluate the therapeutic effect of varying dosages of adjuvant radioactive iodine (RAI) therapy on intermediate-risk papillary thyroid carcinoma (PTC) patients.MethodsThis retrospective study involved a total of 427 intermediate-risk PTC patients, out of which 202 received a 3.7GBq dosage of RAI, and 225 received a 5.55GBq dosage. The evaluation involved assessing the therapeutic outcomes, number of treatment cycles, and successful remnant ablation rates in both dose groups, six months post-adjuvant RAI therapy. Univariate and multivariate logistic regression analyses were employed to identify factors linked with excellent response (ER). Following this, prognostic nomograms were constructed to provide a visual representation of the prediction models. Calibration curves, the concordance index (C-index), and the receiver operating characteristic (ROC) curve were employed to evaluate the predictive performance of these nomograms. The Hosmer-Lemeshow test was applied to assess the models’ goodness-of-fit. Additionally, the clinical utility of the prognostic nomograms was appraised through decision curve analysis (DCA)ResultsThe high-dose (HD) group exhibited significantly higher proportions of ER, single treatment cycles, and successful remnant ablation rates (p<0.05). Being male, receiving a 3.7GBq dose, having an N1b stage, an sTg level ≥10ng/ml, or an sTg/TSH ratio ≥0.11 were independent risk factors for Non-ER. Two prognostic nomograms, “sTg Nomogram” and “sTg/TSH Nomogram”, were established. The ranking of factors contributing to ER, in descending order, included the sTg or sTg/TSH ratio, N stage, therapy dosage, sex, and soft tissue invasion. The “sTg/TSH Nomogram” demonstrated a higher C-index compared to the “sTg Nomogram”. The calibration curves indicated excellent calibration for both nomograms. DCA demonstrated that the net benefit of the “sTg/TSH Nomogram” was higher than that of the “sTg Nomogram”.ConclusionHigher initial RAI therapy doses can improve therapeutic efficacy for intermediate-risk PTC patients. The developed nomograms, particularly the “sTg/TSH Nomogram”, could assist clinicians in optimal therapeutic decision-making