1,661 research outputs found

    A position optimization strategy of the dynamic vibration absorber for the noise control of the power equipment

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    Power equipment shows obvious low frequency line spectrum noise characteristics due to the power frequency. The effective noise control of the power equipment can be achieved by installing dynamic vibration absorbers (DVAs) on the structure surface of electrical equipment. However, if DVAs are not installed properly, considering the cases that they are installed at the vibration mode node position, the low radiation vibration mode and the redistribution of the integrate vibration power, the vibration and noise absorbing performances of DVAs may degrade. In order to achieve efficient vibration absorption and noise reduction on the power equipment, this paper proposes a low-frequency noise reduction technology for power equipment based on DVAs. The position optimization of the DAVs using in the power equipment is studied for the first time. Aimed at the single frequency radiated sound power of equipment, the integrate radiated sound power of the equipment is minimized through adjusting the position parameters of DVAs. A numerical case is studied to verify the effectiveness of the proposed DVAs position optimization. The results show that the noise control effect of the power equipment with the optimized DVAs is significantly improved. The method proposed in this paper solves the noise problem of the power equipment, which provides reference for power noise control

    Multilayer Mo2N-Ag/SiNx films for demanding applications: Morphology, structure and temperature-cycling tribological properties

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    Nowadays there is the need to avoid the excessive consumption of liquid lubricant oils, as they are harmful to the environment and hard to disposal. Self-lubricant films have been seen as the sustainable solution to achieve a long-term lubrication under high temperature-cycling conditions. In this manuscript, multilayer Mo2N-Ag/SiNx films with a fixed modulation ratio (thickness of Mo2N-Ag to SiNx) of 3:1, with changing modulation period (Λ, thickness of Mo2N-Ag and SiNx) from 8 to 200 nm were produced to achieve an effective balance between the lubricious phase diffusion control and the adequate formation of the low friction tribo-layers. Results showed that a dual-phase of fcc-Mo2N and fcc-Ag co-existed in Mo2N-Ag layers, while the SiNx layer exhibited an amorphous character. Both room temperature (RT) lubricant and wear-resistance properties of the films were improved by increasing Λ from 8 to 64 nm, while a further increase of Λ degraded the wear-resistance properties. The multilayer film at Λ = 64 nm exhibited an excellent RT-500 °C temperature-cycling tribological properties. Mechanical properties and the synergistic effect of both modulation layers were the cause for the improvement of the tribological properties.Supported by the National Natural Science Foundation of China, China (51801081, 52071159, 52171071, 52172090); Portugal National Funds through FCT project, Portugal (2021.04115); Outstanding University Young Teachers of ‘‘Qing Lan Project” of Jiangsu Province, China; Excellent Talents of ‘‘Shenlan Project” of Jiangsu University of Science and Technology, China; China Merchants Marine Scientific Research and Innovation Fund, China. Filipe Fernandes acknowledges the funding received in the aim of the projects: MCTool21 - ref. ‘‘POCI-01-0247- FEDER-045940”, CEMMPRE – ref. ‘‘UIDB/00285/2020” and SMARTLUB – ref. ‘‘POCI- 01-0145-FEDER-031807”.info:eu-repo/semantics/publishedVersio

    Isostructural Phase Transition of TiN Under High Pressure

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    In situ high-pressure energy dispersive x-ray diffraction experiments on polycrystalline powder TiN with NaCl-type structure have been conducted with the pressure up to 30.1 GPa by using the diamond anvil cell instrument with synchrotron radiation at room tempearture. The experimental results suggested that an isostructural phase transition might exist at about 7 GPa as revealed by the discontinuity of V/V0 with pressure.Comment: submitte

    Effects of Curcumin on Epidermal Growth Factor in Proliferative Vitreoretinopathy

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    Background/Aims: Proliferative vitreoretinopathy (PVR) is a common refractory eye disease that causes blindness and occurs after retinal detachment or retinal reattachment. Epidermal growth factor (EGF) has been shown to play an important role in the migration and proliferation of retinal pigment epithelium (RPE) cells, which promote PVR. Curcumin inhibits RPE cell proliferation, but it is not known whether it participates in the formation of PVR. Curcumin regulates the biological functions of EGF, which plays important roles in the development of PVR. This study aimed to evaluate the effect of curcumin on the regulation of EGF in PVR. Methods: Rabbit RPE cells were cultured, and EGF expression was detected by immunocytochemistry. MTT assay was conducted to determine cell proliferation induced by different concentrations of EGF. Immunocytochemical staining was used to detect EGF expression after treatment with curcumin at varying concentrations. Real-time PCR (RT-PCR) and western blot analysis were used to detect the concentrations of EGF mRNA and protein after treatment with curcumin. After RPE cells and curcumin were injected into experimental rabbit eyes, the cornea, aqueous humor, lens, and vitreous opacity were observed and recorded simultaneously by indirect ophthalmoscopy, fundus color photography, and B-ultrasonography. The vitreous body was extracted, and the EGF content in the vitreous humor was measured by enzyme-linked immunosorbent assay (ELISA). Results: At each time point (24, 48, and 72 h), cell proliferation gradually increased with increasing EGF concentrations (0, 3, 6, and 9 ng/mL) in a dose-dependent manner. Cell proliferation between EGF concentrations of 9 and 12 ng/mL were no different, which suggested that 9 ng/mL EGF was the best concentration to use to stimulate RPE cell proliferation in vitro. Under all EGF concentrations (0, 3, 6, 9, and 12 ng/mL), RPE cell proliferation increased with time (from 24 to 72 h), suggesting a time–effect relationship. Curcumin downregulated EGF expression in RPE cells, which also indicated time–effect and dose–effect relationships. The best curcumin concentration for the inhibition of EGF expression was 15 µg/mL. RT-PCR and western blot analyses indicated that the EGF mRNA and expression of the protein in RPE cells treated with curcumin significantly decreased with time. Ocular examinations revealed that the vitreous opacity was lower and the proliferative membrane was thinner in the curcumin group compared with the control group. The PVR grade and the incidence of retinal detachment were significantly lower in the experimental group than in the control group. ELISA results showed that the EGF content in vitreous humor was higher in the control group than in the curcumin group. The curcumin and control groups were significantly different at each time point. Conclusion: Curcumin inhibited RPE cell proliferation by downregulating EGF and thus effectively inhibited the initiation and development of PVR

    The oxidative potential of PM10 from coal, briquettes and wood charcoal burnt in an experimental domestic stove

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    Coal contains many potentially harmful trace elements. Coal combustion in unvented stoves, which is common in most parts of rural China, can release harmful emissions into the air that when inhaled cause health issues. However, few studies have dealt specifically with the toxicological mechanisms of the particulate matter (PM) released by coal and other solid fuel combustion. In this paper, PM10 particles that were generated during laboratory stove combustion of raw powdered coal, clay-mixed honeycomb briquettes, and wood charcoal were analysed for morphology, trace element compositions, and toxicity as represented by oxidative DNA damage. The analyses included Field Emission Scanning Electron Microscopy (FESEM), Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Plasmid Scission Assay (PSA). Gravimetric analysis indicated that the equivalent mass concentration of PM10 emitted by burning raw powdered coal was higher than that derived by burning honeycomb briquette. FESEM observation revealed that the coal burning-derived PM10 particles were mainly soot aggregates. The PSA results showed that the PM10 emitted by burning honeycomb briquettes had a higher oxidative capacity than that from burning raw powdered coal and wood charcoal. It is also demonstrated that the oxidative capacity of the whole particle suspensions were similar to those of the water soluble fractions; indicating that the DNA damage induced by coal burning-derived PM10 were mainly a result of the water-soluble fraction. An ICP-MS analysis revealed that the amount of total analysed water-soluble elements in the PM10 emitted by burning honeycomb briquettes was higher than that in PM produced by burning raw powdered coal, and both were higher than PM from burning wood charcoal. The total analysed water-soluble elements in these coal burning-derived PM10 samples had a significantly positive correlation with the level of DNA damage; indicating that the oxidative capacity of the coal burning-derived PM10 was mainly sourced from the water soluble elements. The water-soluble As, Cd, Ge, Mn, Ni, Pb, Sb, Se, Tl, and Zn showed the highest correlation with the oxidative potential, implying that these elements in their water soluble states were the primary responsible factor for the plasmid DNA damage. The exposure risk was further assessed using the particle mass concentrations multiplied by the percent of DNA damage under the dose of 500 μg ml−1. The results revealed that the exposure risk of burning raw powdered coal was much higher than that of burning honeycomb briquette

    Plastrum Testudinis Extracts Promote BMSC Proliferation and Osteogenic Differentiation by Regulating Let-7f-5p and the TNFR2/PI3K/AKT Signaling Pathway

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    Background/Aims: Plastrum testudinis extracts (PTE) show osteoprotective effects on glucocorticoid-induced osteoporosis in vivo and in vitro. However, the underlying molecular mechanism of PTE in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is unclear. Methods: BMSC proliferation was investigated using the Cell Counting Kit-8 assay. BMSC differentiation and osteogenic mineralization were assayed using alkaline phosphatase and Alizarin red staining, respectively. The mRNA expression levels of Let-7f-5p, Tnfr2, Traf2, Pi3k, Akt, β-catenin, Gsk3β, Runx2, and Ocn were measured using real time quantitative polymerase chain reaction. Protein levels of TNFR2, TRAF2, p-PI3K, p-AKT, p-β-CATENIN, and p-GSK3β were analyzed by western blotting. The functional relationship of Let-7f-5p and Tnfr2 was determined by luciferase reporter assays. Results: The optimum concentration for PTE was 30 Οg/ml. PTE significantly promoted BMSC osteogenic differentiation and mineralization after 7 and 14 days in culture, respectively. The combination of PTE and osteogenic induction exhibited significant synergy. PTE upregulated Let-7f-5p, β-catenin, Runx2, and Ocn mRNA expression, and downregulated Tnfr2, Traf2, Pi3k, Akt, and Gsk3β mRNA expression. PTE inhibited TNFR2, TRAF2, and p-β-CATENIN protein expression, and promoted p-PI3K, p-AKT, and p-GSK3β protein expression. In addition, Tnfr2 was a functional target of Let-7f-5p in 293T cells. Conclusions: Our results suggested that PTE may promote BMSC proliferation and osteogenic differentiation via a mechanism associated with the regulation of Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway
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