Sub-arcsec Observations of NGC 7538 IRS 1: Continuum Distribution and Dynamics of Molecular Gas

We report new results based on the analysis of the SMA and CARMA observations of NGC 7538\,IRS\,1 at 1.3 and 3.4 mm with sub-arcsec resolutions. With angular resolutions $\sim$ 0\farcs7, the SMA and CARMA observations show that the continuum emission at 1.3 and 3.4 mm from the hyper-compact \ion{H}{2} region IRS\,1 is dominated by a compact source with a tail-like extended structure to the southwest of IRS\,1. With a CARMA B-array image at 1.3 mm convolved to 0\farcs1, we resolve the hyper-compact \ion{H}{2} region into two components: an unresolved hyper-compact core, and a north-south extension with linear sizes of $<270$ AU and $\sim$2000 AU, respectively. The fine structure observed with CARMA is in good agreement with the previous VLA results at centimeter wavelengths, suggesting that the hyper-compact \ion{H}{2} region at the center of IRS\,1 is associated with an ionized bipolar outflow. We image the molecular lines OCS(19-18) and CH$_3$CN(12-11) as well as $^{13}$CO(2-1) surrounding IRS\,1, showing a velocity gradient along the southwest-northeast direction. The spectral line profiles in $^{13}$CO(2-1), CO(2-1), and HCN(1-0) observed toward IRS\,1 show broad redshifted absorption, providing evidence for gas infall with rates in the range of $3-10\times10^{-3}$ M$_\odot$ yr$^{-1}$ inferred from our observations.Comment: 19 pages, 14 figure

Improving Scene Text Image Super-resolution via Dual Prior Modulation Network

Scene text image super-resolution (STISR) aims to simultaneously increase the resolution and legibility of the text images, and the resulting images will significantly affect the performance of downstream tasks. Although numerous progress has been made, existing approaches raise two crucial issues: (1) They neglect the global structure of the text, which bounds the semantic determinism of the scene text. (2) The priors, e.g., text prior or stroke prior, employed in existing works, are extracted from pre-trained text recognizers. That said, such priors suffer from the domain gap including low resolution and blurriness caused by poor imaging conditions, leading to incorrect guidance. Our work addresses these gaps and proposes a plug-and-play module dubbed Dual Prior Modulation Network (DPMN), which leverages dual image-level priors to bring performance gain over existing approaches. Specifically, two types of prior-guided refinement modules, each using the text mask or graphic recognition result of the low-quality SR image from the preceding layer, are designed to improve the structural clarity and semantic accuracy of the text, respectively. The following attention mechanism hence modulates two quality-enhanced images to attain a superior SR result. Extensive experiments validate that our method improves the image quality and boosts the performance of downstream tasks over five typical approaches on the benchmark. Substantial visualizations and ablation studies demonstrate the advantages of the proposed DPMN. Code is available at: https://github.com/jdfxzzy/DPMN.Comment: Accepted by AAAI-202

Effect of Thiazolidinedione Amide on Insulin Resistance, Creactive Protein and Endothelial Function in Young Women with Polycystic Ovary Syndrome

Purpose: To investigate the effect of thiazolidinedione amide (TZDA) treatment on high-sensitivity Creactive protein (hsCRP) levels and endothelial dysfunction in patients with polycystic ovary syndrome (PCOS).Methods: Twenty five women (mean age 24.7 ± 3.9 years; mean body mass index (BMI), 23.2 ± 4.0 kg/m2) with PCOS were treated with 15 μM TZDA daily for 12 months. Serum levels of testosterone, leutenizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), insulin and hsCRP were measured. BMI, hirsutism scores and insulin sensitivity indices were also calculated prior to and after TZDA treatment. Brachial artery responses to stimuli was used to measure arterial endothelium and smooth muscle function prior to and after the treatment.Results: TZDA treatment caused a significant (p &lt; 0.05) decrease in serum testosterone from 93.1 ± 40.3 to 54.8 ± 19.5 ng/dl and fasting insulin concentration from 11.9 ± 6.8 to 9.23 ± 5.13 U/mL. Insulin resistance index significantly (p &lt; 0.05) improved and hirsutism score decreased significantly from 11.6 ± 2.0 to 6.8 ± 2.0. BMI, waist circumference, serum total cholesterol, low-density lipoprotein (LDL)- cholesterol, FSH and LH levels remained almost unchanged. Twenty-four of the women reverted to regular menstrual cycles. SHBG levels showed a significant (p &lt; 0.05) increase from 24.8 ± 9.5 to 49.1 ± 13.5 nmol/L after TZDA treatment. Serum hsCRP levels decreased (p &lt; 0.05) from 0.25 ± 0.1 to 0.09 ± 0.02 mg/dL while endothelium-dependent vascular responses significantly improved (p &lt; 0.05) following TZDA treatment (9.9 ± 3.9 vs 16.4 ± 5.1%).Conclusion: TZDA treatment improves insulin sensitivity, decreases androgen production and improves endothelial dysfunction in young women with PCOS.Keywords: Thiazolidinedione amide, Insulin sensitivity, Endothelial dysfunction, Polycystic ovary syndrom

The ultra-low-frequency shear modes of 2-4 layer graphenes observed in their scroll structures at edges

The in-plane shear modes between neighbor-layers of 2-4 layer graphenes (LGs) and the corresponding graphene scrolls rolled up by 2-4LGs were investigated by Raman scattering. In contrast to that just one shear mode was observed in 3-4LGs, all the shear modes of 3-4LGs were observed in 3-4 layer scrolls (LSs), whose frequencies agree well with the theoretical predication by both a force-constant model and a linear chain model. In comparison to the broad width (about 12cm$^{-1}$) for the G band in graphite, all the shear modes exhibit an intrinsic line width of about 1.0 cm$^{-1}$. The local electronic structures dependent on the local staking configurations enhance the intensity of the shear modes in corresponding 2-4LSs zones, which makes it possible to observe all the shear modes. It provides a direct evidence that how the band structures of FLGs can be sensitive to local staking configurations. This result can be extended to n layer graphene (n > 4) for the understanding of the basic phonon properties of multi-layer graphenes. This observation of all-scale shear modes can be foreseen in other 2D materials with similar scroll structures.Comment: 14 pages, 5 figure

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

100 ΟM Adenosine treatment did not change the expression of EGFR, VEGF and Akt. (JPG 335 kb

Observation of the chiral anomaly induced negative magneto-resistance in 3D Weyl semi-metal TaAs

Weyl semi-metal is the three dimensional analog of graphene. According to the quantum field theory, the appearance of Weyl points near the Fermi level will cause novel transport phenomena related to chiral anomaly. In the present paper, we report the first experimental evidence for the long-anticipated negative magneto-resistance generated by the chiral anomaly in a newly predicted time-reversal invariant Weyl semi-metal material TaAs. Clear Shubnikov de Haas oscillations (SdH) have been detected starting from very weak magnetic field. Analysis of the SdH peaks gives the Berry phase accumulated along the cyclotron orbits to be {\pi}, indicating the existence of Weyl points.Comment: Submitted in February'1