Aqua­[1-(4-carb­oxy­phen­yl)-1H-imidazole-κN 3](pyridine-2,6-dicarboxyl­ato-κ3 O 2,N,O 6)copper(II) monohydrate

In the title complex, [Cu(C7H3NO4)(C10H8N2O2)(H2O)]·H2O, the CuII ion is in a slightly distorted square-pyramidal geometry. Two carboxyl­ate O atoms and one pyridine N atom from a pyridine-2,6-dicarboxyl­ate ligand chelate the CuII ion, forming two stable five-membered metalla rings. One imidazole N atom from a 1-(4-carb­oxy­phen­yl)imidazole ligand and one water mol­ecule complete the five-coordination. O—H⋯O hydrogen bonds involving the coordinated water mol­ecules and carboxyl­ate groups link the complex mol­ecules into chain-containing dinuclear macrocycles. O—H⋯O hydrogen bonds involving the uncoordinated water mol­ecules link the chains into a layer extending parallel to (10)

HyperQuaternionE:A hyperbolic embedding model for qualitative spatial and temporal reasoning

Qualitative spatial/temporal reasoning (QSR/QTR) plays a key role in research on human cognition, e.g., as it relates to navigation, as well as in work on robotics and artificial intelligence. Although previous work has mainly focused on various spatial and temporal calculi, more recently representation learning techniques such as embedding have been applied to reasoning and inference tasks such as query answering and knowledge base completion. These subsymbolic and learnable representations are well suited for handling noise and efficiency problems that plagued prior work. However, applying embedding techniques to spatial and temporal reasoning has received little attention to date. In this paper, we explore two research questions: (1) How do embedding-based methods perform empirically compared to traditional reasoning methods on QSR/QTR problems? (2) If the embedding-based methods are better, what causes this superiority? In order to answer these questions, we first propose a hyperbolic embedding model, called HyperQuaternionE, to capture varying properties of relations (such as symmetry and anti-symmetry), to learn inversion relations and relation compositions (i.e., composition tables), and to model hierarchical structures over entities induced by transitive relations. We conduct various experiments on two synthetic datasets to demonstrate the advantages of our proposed embedding-based method against existing embedding models as well as traditional reasoners with respect to entity inference and relation inference. Additionally, our qualitative analysis reveals that our method is able to learn conceptual neighborhoods implicitly. We conclude that the success of our method is attributed to its ability to model composition tables and learn conceptual neighbors, which are among the core building blocks of QSR/QTR

A Case of Penile Squamous Cell Carcinoma Associated with HPV58 Infection

We report the case of a 55-year-old man with penile squamous cell car- cinoma (SCC). We found a mass in the patient’s penis, which gradually increased in size. We performed a partial penectomy to remove the mass. Histopathology revealed a highly differentiated squamous cell carcinoma. Human papillomavirus (HPV) DNA was detected by polymerase chain reaction. HPV was found to be pres- ent in the squamous cell carcinoma, and sequencing analysis showed that it was type 58

A Case of Penile Squamous Cell Carcinoma Associated with HPV58 Infection

We report the case of a 55-year-old man with penile squamous cell car- cinoma (SCC). We found a mass in the patient’s penis, which gradually increased in size. We performed a partial penectomy to remove the mass. Histopathology revealed a highly differentiated squamous cell carcinoma. Human papillomavirus (HPV) DNA was detected by polymerase chain reaction. HPV was found to be pres- ent in the squamous cell carcinoma, and sequencing analysis showed that it was type 58

Sequential autologous CAR-T and allogeneic CAR-T therapy successfully treats central nervous system involvement relapsed/refractory ALL: a case report and literature review

BackgroundThe central nervous system (CNS) is the most common site of extramedullary invasion in acute lymphoblastic leukemia (ALL), and involvement of the CNS is often associated with relapse, refractory disease, and poor prognosis. Chimeric antigen receptor-T (CAR-T) cell therapy, a promising modality in cancer immunotherapy, has demonstrated significant advantages in the treatment of hematological malignancies. However, due to associated adverse reactions such as nervous system toxicity, the safety and efficacy of CAR-T cell therapy in treating CNSL remains controversial, with limited reports available.Case reportHere, we present the case of a patient with confirmed B-ALL who experienced relapse in both bone marrow (BM) and cerebrospinal fluid (CSF) despite multiple cycles of chemotherapy and intrathecal injections. The infusion of autologous CD19 CAR-T cells resulted in complete remission (CR) in both BM and CSF for 40 days. However, the patient later experienced a relapse in the bone marrow. Subsequently, allogeneic CD19 CAR-T cells derived from her brother were infused, leading to another achievement of CR in BM. Significantly, only grade 1 cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) events were detected during the treatment period and showed improvement with symptomatic management. During subsequent follow-up, the patient achieved a disease-free survival of 5 months and was successfully bridged to hematopoietic stem cell transplantation.ConclusionOur study provides support for the argument that CNS involvement should not be deemed an absolute contraindication to CAR-T cell therapy. With the implementation of suitable management and treatment strategies, CAR-T therapy can proficiently target tumor cells within the CNS. This treatment option may be particularly beneficial for relapsed or refractory patients, as well as those with central nervous system involvement who have shown limited response to conventional therapies. Additionally, CAR-T cell therapy may serve as a valuable bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in these patients

The interaction between the soluble programmed death ligand-1 (sPD-L1) and PD-1+ regulator B cells mediates immunosuppression in triple-negative breast cancer

Accumulating evidence suggests that regulatory B cells (Bregs) play important roles in inhibiting the immune response in tumors. Programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) are important molecules that maintain the balance of the immune response and immune tolerance. This study aims to evaluate the soluble form of PD-L1 and its function in inducing the differentiation of B lymphocytes, investigate the relationship between soluble PD-L1 (sPD-L1) and B-cell subsets, and explore the antitumor activity of T lymphocytes after PD-L1 blockade in coculture systems. In an effort to explore the role of sPD-L1 in human breast cancer etiology, we examined the levels of sPD-L1 and interleukin-10 (IL-10) in the serum of breast tumor patients and the proportions of B cells, PD-1+ B cells, Bregs, and PD-1+ Bregs in the peripheral blood of patients with breast tumors and assessed their relationship among sPD-L1, IL-10, and B-cell subsets. The levels of sPD-L1 and IL-10 in serum were found to be significantly higher in invasive breast cancer (IBCa) patients than in breast fibroadenoma (FIBma) patients. Meanwhile, the proportions and absolute numbers of Bregs and PD-1+ Bregs in the peripheral blood of IBCa patients were significantly higher than those of FIBma patients. Notably, they were the highest in triple-negative breast cancer (TNBC) among other subtypes of IBCa. Positive correlations of sPD-L1 and IL-10, IL-10 and PD-1+ Bregs, and also sPD-L1 and PD-1+ Bregs were observed in IBCa. We further demonstrated that sPD-L1 could induce Breg differentiation, IL-10 secretion, and IL-10 mRNA expression in a dose-dependent manner in vitro. Finally, the induction of regulatory T cells (Tregs) by Bregs was further shown to suppress the antitumor response and that PD-L1 blockade therapies could promote the apoptosis of tumor cells. Together, these results indicated that sPD-L1 could mediate the differentiation of Bregs, expand CD4+ Tregs and weaken the antitumor activity of CD4+ T cells. PD-L1/PD-1 blockade therapies might be a powerful therapeutic strategy for IBCa patients, particularly for TNBC patients with high level of PD-1+ Bregs

Changes in habitat suitability for waterbirds of the Momoge Nature Reserve of China during 1990–2014

There is increasing empirical evidence that changes in habitat quality play an important role in determining species distributions and biodiversity. However, most research has focused on habitat quality, and we still lack approaches for tracking habitat quality dynamics. In this paper, by establishing qualitative and quantitative relationships between waterbird populations and key habitat indicators such as water abundance, food, shelter conditions and disturbance, we developed an object-oriented classification method, in conjunction with a geographic information systems (GIS) based centroid moving method, to assess habitat suitability dynamics for waterbirds at the Momoge Nature Reserve, China. Our results showed that habitat suitability improved during 1990–2000 and declined during 2000– 2014. Habitats with very good and good grades increased by 71.47 km2 (4.88%) during 1990–2000 and decreased by 200.66 km2 (13.78%) during 2000–2014. The habitat area with a good grade moved to the north, while the habitat area with a poor grade moved to the south during 1990–2014. This was mainly because the surrounding cropland area increased and shifted as oil and gas projects developed. These findings suggest that our object-oriented classification and centroid moving methods have great potential for use in biodiversity conservation and ecosystem management

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor microbiosphere. Currently, the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is unknown. Here, analyses of carbon isotope composition in a ~ 750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition, with anomalous 14C ages likely caused by seismically driven mass transport and the funneling effect of trench geomorphology. Microbial community composition and diverse enzyme activities in the upper ~ 27 cm differed from those at lower depths, probably due to sudden sediment deposition and differences in redox condition and organic matter availability. At lower depths, microbial population numbers, and composition remained relatively constant, except at some discrete depths with altered enzyme activity and microbial phyla abundance, possibly due to additional sudden sedimentation events of different magnitude. Evidence is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic populations. Such depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere