TRADE RELATIONSHIP BETWEEN CHINA AND CENTRAL EASTERN EUROPEAN COUNTRIES

Trade relation between China and Central Eastern European Countries (CEECs) entered into a new stage after CEECs joined EU. The improvement of political relationship boosts the trade expansion between China and CEECs and there is huge potential cooperation space among them. All parties involved in trade should abide by the international rules and keep the faith to promote the further development of economic cooperation. China should adopt strategic measurements to develop healthy trade relationship with CEECs.Trade China CEECs

Unsupervised Generative Adversarial Cross-modal Hashing

Cross-modal hashing aims to map heterogeneous multimedia data into a common Hamming space, which can realize fast and flexible retrieval across different modalities. Unsupervised cross-modal hashing is more flexible and applicable than supervised methods, since no intensive labeling work is involved. However, existing unsupervised methods learn hashing functions by preserving inter and intra correlations, while ignoring the underlying manifold structure across different modalities, which is extremely helpful to capture meaningful nearest neighbors of different modalities for cross-modal retrieval. To address the above problem, in this paper we propose an Unsupervised Generative Adversarial Cross-modal Hashing approach (UGACH), which makes full use of GAN's ability for unsupervised representation learning to exploit the underlying manifold structure of cross-modal data. The main contributions can be summarized as follows: (1) We propose a generative adversarial network to model cross-modal hashing in an unsupervised fashion. In the proposed UGACH, given a data of one modality, the generative model tries to fit the distribution over the manifold structure, and select informative data of another modality to challenge the discriminative model. The discriminative model learns to distinguish the generated data and the true positive data sampled from correlation graph to achieve better retrieval accuracy. These two models are trained in an adversarial way to improve each other and promote hashing function learning. (2) We propose a correlation graph based approach to capture the underlying manifold structure across different modalities, so that data of different modalities but within the same manifold can have smaller Hamming distance and promote retrieval accuracy. Extensive experiments compared with 6 state-of-the-art methods verify the effectiveness of our proposed approach.Comment: 8 pages, accepted by 32th AAAI Conference on Artificial Intelligence (AAAI), 201

Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing.

The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation. We studied the expression level of a questionable (Q) HLA-B*38:68Q allele, which carries a 9-nucleotide (nt) deletion at codon 230-232 in exon 4 of HLA-B*38:01:01:01 using CRISPR/Cas9 gene editing technology. CRISPR/Cas9 gene editing of HLA-B*38:01:01:01 homozygous EBV B cell line resulted in one HLA-B*38:68Q/B*38:01:01:01 heterozygous and one HLA-B*38:68Q homozygous clone. Flow cytometric analysis of monoclonal anti-Bw4 antibody showed the protein expression of HLA-B*38:01:01:01 in homozygous cells was 2.2 fold higher than HLA-B*38:68Q/B*38:01:01:01 heterozygous cells, and the expression of HLA-B*38:68Q/B*38:01:01:01 heterozygous cells was over 2.0 fold higher than HLA-B*38:68Q homozygous cells. The HLA-B*38:68Q expression was further confirmed using anti-B38 polyclonal antibody. Similarly, the expression of the HLA-B*38:01:01:01 homozygous cells was 1.5 fold higher than that of HLA-B*38:68Q/B*38:01:01:01 heterozygous cells, and the HLA-B*38:68Q/B*38:01:01:01 heterozygous cells was over 1.6 fold higher than that of HLA-B*38:68Q homozygous cells. The treatment of HLA-B*38:68Q homozygous cells with IFN-γ significantly increased its expression. In conclusion, we demonstrate that HLA-B*38:68Q is a low-expressing HLA allele. The CRISPR/Cas9 technology is a useful tool to induce precise gene editing in HLA genes to enable the characterization of HLA gene variants on expression and function

Study of the relationships between evoked potentials, inspection time and intelligence

This thesis examines the relationships between average evoked potentials (AEPs), inspection time (IT) and intelligence, by relating visual AEPs evoked by the stimuli of an inspection time task (and by similar stimuli for which an IT-type discrimination was not required) to subjects' IT estimates, and to their intellectual ability as measured by intelligence tests.Earlier work on IT and AEP in relation to intelligence is reviewed.Evoked potentials were collected while subjects were performing an IT (or an equivalent) task. In Experiments 1 & 2, it was found that a measure of the P200 ("P200r"· defined in Chapters 3 and 4) of AEPs to the IT task stimuli correlated significantly with IT (Pearson: r=0.57, p<.05). Experiment 3 replicated this finding (r=.44, p<.05). Also, Experiment 3 found that P200 latency could be related to IT (r=.55, p<.05). These results were obtained again in Experiment 6 (r=.645, p<.0005. for P200T; r=.442, p<.005 ,for P200 latency). It is inferred from these results and those reported by other authors that P200 reflects the process of encoding or transferring information from a sensory register into short-term memory (STM). Further, it is argued that inspection time indexes the rate at which sensory input is sampled in the initial stages of information processing.Several techniques were used to examine the relationship between the P300 component and IT. P300 latency was not closely related to IT, but P300 amplitude corre lated positively and significantly with IT (Experiment 6). P300 amplitude reflected subjects' confidence in their performance of a task, and this result suggests that subjects' choice of a more stringent criterion of confidence for their judgements may contribute to their longer measured ITs.Another factor which may also play a part in subjects' performance in the IT task is the process of anticipation of task stimulus. When the warning period was extended from 500 msec to 1800 msec (in Experiments 4 and 5), it was found that the strength of anticipation, as Indexed by the amplitude of contingent negative variation (CNV), correlated positively with IT. This suggests that strong anticipation may, under these conditions, handicap subjects' performance on the IT task.Experiment 6 examined the relationships between 10. IT and the measures of AEPs previously found to correlate with IT. Each subject was presented with his/her IT-duration stimulus. Half of the presentations were designated as "task-loaded" trials requiring an IT response. and the other half the "task-free" trials requiring no IT response, with the two kinds of trials randomly intermixed. In each trial, subjects were asked to give a reaction-time response to a visual signal following the IT-duration stimulus.In this experiment as expected, IT correlated negatively with intelligence test scores. The previously identified parameters of AEPs to the IT-duration stimulus with task requirements correlated with IT, but not 10; these therefore reflect task-specific individual differences. In contrast measures of the P200 to the digit stimuli which identified the nature of a trial (i .e. with or without IT-task requirements) did correlate with 10. and reflect individual differences related to general cognitive ability. Subjects' inspection time also correlated with the non-specific AEP differences.In the light of the results described above, the IT-10 relation may be seen to depend on a general speed factor. reflecting the process of encoding sensory input into STM from a sensory register. The higher the speed of this encoding process (i.e. smaller values of the P200 temporal measures), the shorter the inspection time and the higher the intelligence test score