217 research outputs found
A stability condition for turbulence model: From EMMS model to EMMS-based turbulence model
The closure problem of turbulence is still a challenging issue in turbulence
modeling. In this work, a stability condition is used to close turbulence.
Specifically, we regard single-phase flow as a mixture of turbulent and
non-turbulent fluids, separating the structure of turbulence. Subsequently,
according to the picture of the turbulent eddy cascade, the energy contained in
turbulent flow is decomposed into different parts and then quantified. A
turbulence stability condition, similar to the principle of the
energy-minimization multi-scale (EMMS) model for gas-solid systems, is
formulated to close the dynamic constraint equations of turbulence, allowing
the heterogeneous structural parameters of turbulence to be optimized. We call
this model the `EMMS-based turbulence model', and use it to construct the
corresponding turbulent viscosity coefficient. To validate the EMMS-based
turbulence model, it is used to simulate two classical benchmark problems,
lid-driven cavity flow and turbulent flow with forced convection in an empty
room. The numerical results show that the EMMS-based turbulence model improves
the accuracy of turbulence modeling due to it considers the principle of
compromise in competition between viscosity and inertia.Comment: 26 pages, 13 figures, 2 table
CFD simulation of the influence of suspension section on the hydrodynamics of CFB riser
The gas-solid two-phase flow in a circulating fluidized bed (CFB) is affected by hydrodynamic factors (say, superficial gas velocity, solids flux, solids inventory) , material properties (say, particle diameter) and geometric factors such as the entry and exit configuration (1-5). For example, Li (5) found that the axial profile in a CFB is heavily dependent on the length of the suspension section, which refers to the part between the riser bottom and the recycle inlet of solids. The variation of the suspension section may result in exponentially decaying or S-shaped profiles. However, most of computational fluid dynamics (CFD) simulations, especially the 2D simulations, do not take into account this factor (6-8). In this work, we perform 3D, full-loop simulation of a CFB with different lengths of suspension section in the riser, as shown in Fig. 1. The simulation results reveal that the axial profiles in the riser with longer suspension section are more likely S-shaped, which is consistent with the literature (Fig. 2). This suggests a need of full-loop simulation of CFB to understand the complicated dependence of hydrodynamics on geometric factors.
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Effects of stochastic tow waviness on stiffness and strength of plain-weave ceramic matrix composites
This article presents the development of a finite element model, which considers stochastic tow waviness using a Markov Chain algorithm and non-linear material properties using Binary Model, to predict the stress–strain and fracture behaviour of plain-weave ceramic matrix composites under uniaxial extension. The stochastic waviness is described by fluctuations in the centroid coordinates of tow positioning. The tow deviations are generated by marching sequentially from one grid point to next along a tow path. The deviations depend only on the deviation of the previous point using a probability transition matrix. A non-linear orthotropic constitutive model was implemented in a commercial finite element code Abaqus using a user-defined subroutine. Two 2 × 2 unit cell models of a plain-weave ceramic matrix composite laminate are created using stochastic tow elements generated by the virtual specimen generator, which was developed on the basis of the Markov Chain algorithm. A comparison has been made between the systematic and stochastic models to assess the effects of stochastic tow waviness on the stiffness and strength of the laminate. The numerical results have been validated by the comparison of predictions with the experimental data. The stochastic model which considers random waviness correlates well with the experimental data
3D CFD Simulation of Combustion in a 150 MWe Circulating Fluidized Bed Boiler
Eulerian granular multiphase model with meso-scale modeling of drag coefficient and mass transfer coefficient, based on the energy minimization multi-scale (EMMS) model, was presented to simulate a 150 MWe CFB boiler. The three-dimensional (3D), full-loop, time-dependent simulation results were presented in terms of the profiles of pressure, solids volume fraction and solids vertical velocity, the distributions of carbon and oxygen, as well as the temperature. The EMMS-based sub-grid modeling allows using coarse grid with proven accuracy, and hence it is suitable for simulation of such large-scale industrial reactors
Lattice Boltzmann based discrete simulation for gas-solid fluidization
Discrete particle simulation, a combined approach of computational fluid
dynamics and discrete methods such as DEM (Discrete Element Method), DSMC
(Direct Simulation Monte Carlo), SPH (Smoothed Particle Hydrodynamics), PIC
(Particle-In-Cell), etc., is becoming a practical tool for exploring lab-scale
gas-solid systems owing to the fast development of parallel computation.
However, gas-solid coupling and the corresponding fluid flow solver remain
immature. In this work, we propose a modified lattice Boltzmann approach to
consider the effect of both the local solid volume fraction and the local
relative velocity between particles and fluid, which is different from the
traditional volume-averaged Navier-Stokes equations. A time-driven hard sphere
algorithm is combined to simulate the motion of individual particles, in which
particles interact with each other via hard-sphere collisions, the collision
detection and motion of particles are performed at constant time intervals. The
EMMS (energy minimization multi-scale) drag is coupled with the lattice
Boltzmann based discrete particle simulation to improve the accuracy. Two
typical fluidization processes, namely, a single bubble injection at incipient
fluidization and particle clustering in a fast fluidized bed riser, are
simulated with this approach, with the results showing a good agreement with
published correlations and experimental data. The capability of the approach to
capture more detailed and intrinsic characteristics of particle-fluid systems
is demonstrated. The method can also be used straightforward with other solid
phase solvers.Comment: 15 pages, 11 figures, 2 tables. In Chemical Engineering Science, 201
Analytical Multi-Scale Methodology for Fluidization Systems - Retrospect and Prospect
Understanding the spatio-temporal multi-scale structure of fluidization is a challenging problem. This presentation reviews our 20-year efforts on this subject, showing the roadmap that has gradually evolved from a simple idea to a systematic methodology inclusive of subsidiary, related systems and industrial applications. The strategy of establishing stability conditions through analyses of the compromise between dominant mechanisms is emphasized. The presentation concludes with prospects for further theoretical explorations and industrial applications
Numerical simulation of scale-up effects of methanol-to-olefins fluidized bed reactors
Scale-up of fluidized bed reactors has long been regarded as a big challenge in chemical reaction engineering. While traditional scaling theories are mostly based on hydrodynamics similarity, computational fluid dynamics (CFD) aided approach allows direct coupling between hydrodynamics and reaction factors and is expected to speed up the experiment-based scale-up process with lower cost. In this study, we aim to investigate the scale-up effects through simulations of a series of methanol-to-olefins (MTO) reactors of different sizes. The two-fluid model and energy-minimization multi-scale (EMMS)-based drag models, are combined in simulations. The fluidization characteristics in terms of flow structures, velocity distribution, mass fractions of gaseous product and coke distribution are presented against available experimental data for different-sized reactors. It is found that typical hydrodynamic features can be reasonably predicted, while the prediction of reaction behavior shows growing discrepancy with increasing reactor size. Possible reasons are discussed in the last section along with future work presented for scale-up studies. (C) 2017 Elsevier Ltd. All rights reserved
MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells
Introduction: Thyroid cancer (TC) is a common endocrine malignancy, comprising nearly one-third of all head and neck malignancies worldwide. MicroRNAs (miRNAs) have been implicated in the malignant progression of multiple cancers; however, their contribution to thyroid diseases has not been fully explored.
Material and methods: This study aimed to illustrate the regulatory mechanism of microRNA-196a-5p in TC progression and to investigate whether microRNA-196a-5p affects progression of TC cells by targeting low-density lipoprotein receptor-associated protein 1B (LRP1B). MicroRNA-196a-5p and LRP1B expression status in TC cells and normal human thyroid cells was detected by quantative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Dual-luciferase reporter assay, cell counting kit-8 (CCK-8) assay, scratch healing assay, and Transwell assay were also performed.
Results: The results showed that microRNA-196a-5p expression was up-regulated and LRP1B expression was down regulated in TC cells. In addition, the upregulation of microRNA-196a-5p facilitated progression of TC cells. Silencing microRNA-196a-5p led to the opposite results. Dual-luciferase reporter assay offered evidence for microRNA-196a-5p targeting LRP1B in TC. MicroRNA-196a-5p could target LRP1B to facilitate proliferation, invasion, and migration of TC cells.
Conclusion: Overall, this study revealed that microRNA-196a-5p may be a cancer-promoting microRNA that plays an important role in TC progression
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