PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.

PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway. RBM38 RNA-binding protein, also called RNPC1 and a target of p53, inhibits p53 messenger RNA (mRNA) translation, which can be reversed by GSK3 protein kinase via phosphorylation of RBM38 at serine 195. Here we showed that ectopic expression of RBM38 increases, whereas knockdown of RBM38 inhibits, PPM1D mRNA translation. Consistent with this, we found that RBM38 directly binds to PPM1D 3'-untranslated region (3'-UTR) and promotes expression of a heterologous reporter gene that carries PPM1D 3'-UTR in a dose-dependent manner. Interestingly, we showed that PPM1D directly interacts with and dephosphorylates RBM38 at serine 195. Furthermore, we showed that PPM1D modulates p53 mRNA translation and p53-dependent growth suppression through dephosphorylation of RBM38. These findings provide evidence that the crosstalk between PPM1D and RBM38, both of which are targets and modulators of p53, has a critical role in p53 expression and activity

Dynamical chiral symmetry breaking in sliding nanotubes

We discovered in simulations of sliding coaxial nanotubes an unanticipated example of dynamical symmetry breaking taking place at the nanoscale. While both nanotubes are perfectly left-right symmetric and nonchiral, a nonzero angular momentum of phonon origin appears spontaneously at a series of critical sliding velocities, in correspondence with large peaks of the sliding friction. The non-linear equations governing this phenomenon resemble the rotational instability of a forced string. However, several new elements, exquisitely "nano" appear here, with the crucial involvement of Umklapp and of sliding nanofriction.Comment: To appear in PR

Microcanonical Thermodynamics of First Order Phase Transitions studied in the Potts Model

Phase transitions of first and second order can easily be distinguished in small systems in the microcanonical ensemble. Configurations of phase coexistence, which are suppressed in the canonical formulation, carry important information about the main characteristics of first order phase transitions like the transition temperature, the latent heat, and the interphase surface tension. The characterisitc backbending of the micro- canonical caloric equation of state T(E) (not to be confused with the well known Van der Waals loops in ordinary thermodynamics) leading to a negative specific heat is intimatly linked to the interphase surface entropy.Comment: Latex, 4 eps-figures, graphicx.st

Quadratic Algebra Approach to Relativistic Quantum Smorodinsky-Winternitz Systems

There exist a relation between the Klein-Gordon and the Dirac equations with scalar and vector potentials of equal magnitude (SVPEM) and the Schrodinger equation. We obtain the relativistic energy spectrum for the four Smorodinsky-Winternitz systems from the quasi-Hamiltonian and the quadratic algebras obtained by Daskaloyannis in the non-relativistic context. We point out how results obtained in context of quantum superintegrable systems and their polynomial algebras may be applied to the quantum relativistic case. We also present the symmetry algebra of the Dirac equation for these four systems and show that the quadratic algebra obtained is equivalent to the one obtained from the quasi-Hamiltonian.Comment: 19 page

Relativistic description of J/\psi dissociation in hot matter

The mass spectra and binding radii of heavy quark bound states are studied on the basis of the reduced Bethe-Salpeter equation. The critical values of screening masses for $c\bar{c}$ and $b\bar{b}$ bound states at a finite temperature are obtained and compared with the previous results given by non-relativistic models.Comment: 13 latex pages, 2 figure