Practical and Secure Outsourcing Algorithms of Matrix Operations Based on a Novel Matrix Encryption Method

With the recent growth and commercialization of cloud computing, outsourcing computation has become one of the most important cloud services, which allows the resource-constrained clients to efficiently perform large-scale computation in a pay-per-use manner. Meanwhile, outsourcing large scale computing problems and computationally intensive applications to the cloud has become prevalent in the science and engineering computing community. As important fundamental operations, large-scale matrix multiplication computation (MMC), matrix inversion computation (MIC), and matrix determinant computation (MDC) have been frequently used. In this paper, we present three new algorithms to enable secure, verifiable, and efficient outsourcing of MMC, MIC, and MDC operations to a cloud that may be potentially malicious. The main idea behind our algorithms is a novel matrix encryption/decryption method utilizing consecutive and sparse unimodular matrix transformations. Compared to previous works, this versatile technique can be applied to many matrix operations while achieving a good balance between security and efficiency. First, the proposed algorithms provide robust confidentiality by concealing the local information of the entries in the input matrices. Besides, they also protect the statistic information of the original matrix. Moreover, these algorithms are highly efficient. Our theoretical analysis indicates that the proposed algorithms reduce the time overhead on the client side from O(n 2.3728639 ) to O(n 2 ). Finally, the extensive experimental evaluations demonstrate the practical efficiency and effectiveness of our algorithms

Integrated Multi-omics Analysis Using Variational Autoencoders: Application to Pan-cancer Classification

Different aspects of a clinical sample can be revealed by multiple types of omics data. Integrated analysis of multi-omics data provides a comprehensive view of patients, which has the potential to facilitate more accurate clinical decision making. However, omics data are normally high dimensional with large number of molecular features and relatively small number of available samples with clinical labels. The "dimensionality curse" makes it challenging to train a machine learning model using high dimensional omics data like DNA methylation and gene expression profiles. Here we propose an end-to-end deep learning model called OmiVAE to extract low dimensional features and classify samples from multi-omics data. OmiVAE combines the basic structure of variational autoencoders with a classification network to achieve task-oriented feature extraction and multi-class classification. The training procedure of OmiVAE is comprised of an unsupervised phase without the classifier and a supervised phase with the classifier. During the unsupervised phase, a hierarchical cluster structure of samples can be automatically formed without the need for labels. And in the supervised phase, OmiVAE achieved an average classification accuracy of 97.49% after 10-fold cross-validation among 33 tumour types and normal samples, which shows better performance than other existing methods. The OmiVAE model learned from multi-omics data outperformed that using only one type of omics data, which indicates that the complementary information from different omics datatypes provides useful insights for biomedical tasks like cancer classification.Comment: 7 pages, 4 figure

Unsupervised Annotation of Phenotypic Abnormalities via Semantic Latent Representations on Electronic Health Records

The extraction of phenotype information which is naturally contained in electronic health records (EHRs) has been found to be useful in various clinical informatics applications such as disease diagnosis. However, due to imprecise descriptions, lack of gold standards and the demand for efficiency, annotating phenotypic abnormalities on millions of EHR narratives is still challenging. In this work, we propose a novel unsupervised deep learning framework to annotate the phenotypic abnormalities from EHRs via semantic latent representations. The proposed framework takes the advantage of Human Phenotype Ontology (HPO), which is a knowledge base of phenotypic abnormalities, to standardize the annotation results. Experiments have been conducted on 52,722 EHRs from MIMIC-III dataset. Quantitative and qualitative analysis have shown the proposed framework achieves state-of-the-art annotation performance and computational efficiency compared with other methods.Comment: Accepted by BIBM 2019 (Regular

Facial expression recognition method on static and dynamic image

This article is dedicated to analyze various facial expression recognition method based on different type of image, which aim at extracting feature on the image. Considering the method to optimize existing method

Manipulating Complex Robot Behavior for Autonomous and Continuous Operations

Service robot control faces challenges of dynamic environment and complex behavior, which mainly include eye-hand coordination and continuous operations. However, current programming scheme lacks the ability of managing such tasks. In this chapter, we propose a methodology of software development paradigm for the continuous operation of the dual-arm picking robot. First, a dual-arm robot is built for picking with the purpose of selectively harvesting in plant factory. Second, a hierarchical control software is framed by means of “Sense Plan Act” (SPA) paradigm. Third, based on the previous design, programming concept, and the ROS system, the sub-node programming of visual module, motion module, eye-hand coordination module, and task planning module are implemented with a state machine-based architecture. The experimental results show that if total number of targets within the visual field is not more than three, the average picking time is less than 35 s. The fluency of concurrent task management shows the feasibility of manipulating complex robot behavior for autonomous and continuous operations with the finite state machine model and task level architecture