A note on the generalized Geroch conjecture for complete spin manifolds

Let $W$ be a closed area enlargeable manifold in the sense of Gromov-Lawson and $M$ a noncompact spin manifold, we show that the connected sum $M\# W$ admits no complete metric of positive scalar curvature. When $W=T^n$, this provides a positive answer to the generalized Geroch conjecture in the spin setting.Comment: 4 pages, comments are welcome

Nonlinear dynamic characteristic of the spindle-cutter system

A nonlinear dynamic model of spindle-cutter coupling system under cutting force, which takes into account the cutter stiffness and the nonlinearity of bearing clearance, is established. Analysis of the cross-section of a two-flute end mill is conducted to determine cutter stiffness. Then, the calculated cutter stiffness is introduced into the nonlinear dynamic model of coupling system. In the modeling of cutting force, the cutting width takes into account the cutter tip displacement. Moreover, nonlinear dynamic characteristics of spindle-cutter coupling system are studied and the effects of bearing clearance on the response of cutter tip are discussed as well, considering unbalanced force. The numerical results show that the bearing clearance strongly affects the equilibrium position. With different values of bearing clearance and rotation speed, the responses of cutter tip exhibit periodic, quasi-periodic and chaotic characteristics. Dynamic characteristics of spindle-cutter system depends on the bearing clearance and rotation speed. The proper bearing clearance and rotation speed should be chosen to ensure a stable cutting and high cutting rate according to the bifurcation diagram. The response of the cutter tip is a quasi-periodic motion when the cutting force is considered. The time-domain response of cutter tip predicted by nonlinear dynamic analysis can provide the basis for machining error prediction

(4R)-Ethyl 4-(4-chloro­phen­yl)-2-hydr­oxy-5-oxo-2,3,4,5-tetra­hydro­pyrano[3,2-c]chromene-2-carboxyl­ate. Corrigendum

Corrigendum to Acta Cryst. (2010), E66, o217

Draft Genome Sequence of the Caffeine-Degrading Methylotroph Methylorubrum populi Pinkel.

A pink-pigmented facultative methylotroph, Methylorubrum populi Pinkel, was isolated from compost by selective enrichment with caffeine (3,5,7-trimethylxanthine) as the sole carbon, nitrogen, and energy source. We report here its high-quality draft genome sequence, assembled in 35 contigs totaling 5,630,907 bp. We identified 5,681 protein-coding sequences, including those putatively involved in caffeine degradation

Gastric microbiota dysbiosis and Helicobacter pylori infection

Helicobacter pylori (H. pylori) infection is one of the most common causes of gastric disease. The persistent increase in antibiotic resistance worldwide has made H. pylori eradication challenging for clinicians. The stomach is unsterile and characterized by a unique niche. Communication among microorganisms in the stomach results in diverse microbial fitness, population dynamics, and functional capacities, which may be positive, negative, or neutral. Here, we review gastric microecology, its imbalance, and gastric diseases. Moreover, we summarize the relationship between H. pylori and gastric microecology, including non-H. pylori bacteria, fungi, and viruses and the possibility of facilitating H. pylori eradication by gastric microecology modulation, including probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation

Optimization of nano coating to reduce the thermal deformation of ball screws

To reduce the thermal deformation of ball screws, the process of nano coating preparation for coating on ball screws to reduce temperature rise and thereby thermal deformation was discussed in this article. Simultaneously, the cooling mechanism was presented. The thermal channels and the relatively even distribution of graphene in the nano coating were observed in scanning electron microscopic images. In terms of the preparation of nano coating, optimization design was carried out to obtain the optimized material ratio and nozzle flow through orthogonal experiment. The influence of design parameters of nano coating on reducing thermal deformation was also discussed. The experimental results show that the maximum temperature rise, thermal deformation, and time to reach thermal balance decreased by 12.5, 69.1, and 46.3%, respectively. The effectiveness of nano coating in reducing thermal deformation was validated experimentally

Ethyl (2S,4R)-4-(4-bromo­phen­yl)-2-hydr­oxy-5,10-dioxo-3,4,5,10-tetra­hydro-2H-benzo[g]chromene-2-carboxyl­ate

In the crystal structure of the title compound, C22H17BrO6, the quinone ring makes a dihedral angle of 81.84 (3)° with the benzene ring. The chiral C atoms, viz. the ring C atoms bearing the hydr­oxy and bromo­phenyl substituents, exhibit R and S configurations, respectively. The terminal ethyl group of the –CO2CH2CH3 group is disordered over two sets of sites with site-occupancy factors of 0.64 (1) and 0.36 (1). Inter­molecular O—H⋯O inter­actions further stabilize the crystal packing

A novel hand-eye calibration method of picking robot based on TOF camera

Aiming at the stability of hand-eye calibration in fruit picking scene, a simple hand-eye calibration method for picking robot based on optimization combined with TOF (Time of Flight) camera is proposed. This method needs to fix the TOF depth camera at actual and calculated coordinates of the peach the end of the robot, operate the robot to take pictures of the calibration board from different poses, and record the current photographing poses to ensure that each group of pictures is clear and complete, so as to use the TOF depth camera to image the calibration board. Obtain multiple sets of calibration board depth maps and corresponding point cloud data, that is, “eye” data. Through the circle center extraction and positioning algorithm, the circle center points on each group of calibration plates are extracted, and a circle center sorting method based on the vector angle and the center of mass coordinates is designed to solve the circle center caused by factors such as mirror distortion, uneven illumination and different photographing poses. And through the tool center point of the actuator, the coordinate value of the circle center point on the four corners of each group of calibration plates in the robot end coordinate system is located in turn, and the “hand” data is obtained. Combined with the SVD method, And according to the obtained point residuals, the weight coefficients of the marker points are redistributed, and the hand-eye parameters are iteratively optimized, which improves the accuracy and stability of the hand-eye calibration. the method proposed in this paper has a better ability to locate the gross error under the environment of large gross errors. In order to verify the feasibility of the hand-eye calibration method, the indoor picking experiment was simulated, and the peaches were identified and positioned by combining deep learning and 3D vision to verify the proposed hand-eye calibration method. The JAKA six-axis robot and TuYang depth camera are used to build the experimental platform. The experimental results show that the method is simple to operate, has good stability, and the calibration plate is easy to manufacture and low in cost. work accuracy requirements

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.

Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells. KMT2A knockdown significantly inhibited cell viability and cell migration and induced apoptosis, whereas KMT2A overexpression effectively promoted cell proliferation in various melanoma cell lines. Further study showed that KMT2A regulated melanoma cell growth by targeting the hTERT-dependent signal pathway. Knockdown of KMT2A markedly inhibited the promoter activity and expression of hTERT, and hTERT overexpression rescued the viability inhibition caused by KMT2A knockdown. Moreover, KMT2A knockdown suppressed tumorsphere formation and the expression of cancer stem cell markers, which was also reversed by hTERT overexpression. In addition, the results from a xenograft mouse model confirmed that KMT2A promoted melanoma growth via hTERT signaling. Finally, analyses of clinical samples demonstrated that the expression of KMT2A and hTERT were positively correlated in melanoma tumor tissues, and KMT2A high expression predicted poor prognosis in melanoma patients. Collectively, our results indicate that KMT2A promotes melanoma growth by activating the hTERT signaling, suggesting that the KMT2A/hTERT signaling pathway may be a potential therapeutic target for melanoma