551 research outputs found
Exploring the Potential of Large Language Models in Generating Code-Tracing Questions for Introductory Programming Courses
In this paper, we explore the application of large language models (LLMs) for
generating code-tracing questions in introductory programming courses. We
designed targeted prompts for GPT4, guiding it to generate code-tracing
questions based on code snippets and descriptions. We established a set of
human evaluation metrics to assess the quality of questions produced by the
model compared to those created by human experts. Our analysis provides
insights into the capabilities and potential of LLMs in generating diverse
code-tracing questions. Additionally, we present a unique dataset of human and
LLM-generated tracing questions, serving as a valuable resource for both the
education and NLP research communities. This work contributes to the ongoing
dialogue on the potential uses of LLMs in educational settings.Comment: Accepted by Findings of EMNLP, 202
Progress of Clinical Research on the Treatment of Hyperplasia of Mammary Glands by Auricular Plaster Therapy
Hyperplasia of mammary glands (HMG), the most common benign breast disease in women of childbearing age, often has a long and recurrent course. Because of its mild pain, long-lasting efficacy, ease of operation, non-toxic side effects, ease of acceptance, and remarkable efficacy especially for pain, auricular plaster therapy has created a new way for the treatment of HMG. This article analyzes the efficacy of the current treatment of HMG by auricular plaster therapy, in order to pave the way for finding an ideal solution for the treatment of HMG by auricular plaster therapy in the future
Classification of Cognitive Level of Patients with Leukoaraiosis on the Basis of Linear and Non-Linear Functional Connectivity
Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.
Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells. The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-κB proteins, and abrogated the binding of NF-κB on COX-2 promoter. Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy
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