17,027 research outputs found

    Optimal phase space projection for noise reduction

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    In this communication we will re-examine the widely studied technique of phase space projection. By imposing a time domain constraint (TDC) on the residual noise, we deduce a more general version of the optimal projector, which includes those appearing in previous literature as subcases but does not assume the independence between the clean signal and the noise. As an application, we will apply this technique for noise reduction. Numerical results show that our algorithm has succeeded in augmenting the signal-to-noise ratio (SNR) for simulated data from the R\"ossler system and experimental speech record.Comment: Accepted version for PR

    Models of Financial Markets with Extensive Participation Incentives

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    We consider models of financial markets in which all parties involved find incentives to participate. Strategies are evaluated directly by their virtual wealths. By tuning the price sensitivity and market impact, a phase diagram with several attractor behaviors resembling those of real markets emerge, reflecting the roles played by the arbitrageurs and trendsetters, and including a phase with irregular price trends and positive sums. The positive-sumness of the players' wealths provides participation incentives for them. Evolution and the bid-ask spread provide mechanisms for the gain in wealth of both the players and market-makers. New players survive in the market if the evolutionary rate is sufficiently slow. We test the applicability of the model on real Hang Seng Index data over 20 years. Comparisons with other models show that our model has a superior average performance when applied to real financial data.Comment: 17 pages, 16 figure

    Surface Waves on a Semi-toroidal Water Ring

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    We study the dynamics of surface waves on a semi-toroidal ring of water that is excited by vertical vibration. We create this specific fluid volume by patterning a glass plate with a hydrophobic coating, which confines the fluid to a precise geometric region. To excite the system, the supporting plate is vibrated up and down, thus accelerating and decelerating the fluid ring along its toroidal axis. When the driving acceleration is sufficiently high, the surface develops a standing wave, and at yet larger accelerations, a traveling wave emerges. We also explore frequency dependencies and other geometric shapes of confinement

    Highway Performance and Time-Sensitive Industries

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    Communities and states are using every means available to them to attract and retain economic activity. One such strategy is to plan for the changing needs of new and existing businesses. In the past two decades, firms have come to view time as one of their most precious resources. Some businesses have adopted efficiently timed production methods like just-in-time, in which inventory and safety stock are minimized; deliveries of intermediate goods at all stages of production are synchronized with suppliers so that at no point do products linger. Highway projects that reduce unanticipated delays enhance the ability of time sensitive businesses to maintain closely timed production and sales schedules. Perhaps the most important type of delay in this context is that produced by incidents, which are events that disrupt normal traffic flow. In addition to accidents, incidents include stalled vehicles, debris on the road, or other impediments to orderly flow. While they are rare events, incidents do happen, and they can greatly affect travel times, especially on roads operating at near capacity. Highway improvements can reduce the likelihood of incidents and reduce the severity of impacts when incidents do occur. How to measure increases in highway system performance for time-sensitive businesses when these systems are upgraded is a focus of this monograph. We begin by examining the changes in the business environment that precipitated the movement toward time-sensitive production. Then, from an extensive survey, we conclude that although businesses in Iowa are somewhat less time-sensitive than businesses in many other places, Iowa’s businesses anticipate tighter production schedules in the future. We show how traffic incidents and incident-produced congestion erode highway performance for time-sensitive industries. An analysis of the causes and consequences of incident-produced delays provides the foundation for our model of incident-produced delay, which we have developed to gauge highway performance for time-sensitive firms. This research was a joint effort between researchers at the University of Iowa Public Policy Center and Iowa State University’s Department of Transportation and Logistics. The Iowa Department of Transportation provided funding for this project

    Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants

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    Genetic screening using random transposon insertions has been a powerful tool for uncovering biology in prokaryotes, where whole-genome saturating screens have been performed in multiple organisms. In eukaryotes, such screens have proven more problematic, in part because of the lack of a sensitive and robust system for identifying transposon insertion sites. We here describe quantitative insertion-site sequencing, or QIseq, which uses custom library preparation and Illumina sequencing technology and is able to identify insertion sites from both the 5' and 3' ends of the transposon, providing an inbuilt level of validation. The approach was developed using piggyBac mutants in the human malaria parasite Plasmodium falciparum but should be applicable to many other eukaryotic genomes. QIseq proved accurate, confirming known sites in >100 mutants, and sensitive, identifying and monitoring sites over a >10,000-fold dynamic range of sequence counts. Applying QIseq to uncloned parasites shortly after transfections revealed multiple insertions in mixed populations and suggests that >4000 independent mutants could be generated from relatively modest scales of transfection, providing a clear pathway to genome-scale screens in P. falciparum QIseq was also used to monitor the growth of pools of previously cloned mutants and reproducibly differentiated between deleterious and neutral mutations in competitive growth. Among the mutants with fitness defects was a mutant with a piggyBac insertion immediately upstream of the kelch protein K13 gene associated with artemisinin resistance, implying mutants in this gene may have competitive fitness costs. QIseq has the potential to enable the scale-up of piggyBac-mediated genetics across multiple eukaryotic systems

    Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked \u3cem\u3ein vivo\u3c/em\u3e Using Molecular Imaging

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    Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was to evaluate the ability of 99mTc-hexamethylpropyleneamineoxime (HMPAO) and 99mTc-duramycin to track the effectiveness of H2 therapy in vivo in the hyperoxia rat model of ALI. Rats were exposed to room air (normoxia), 98% O2 + 2% N2 (hyperoxia) or 98% O2 + 2% H2 (hyperoxia+H2) for up to 60 h. In vivo scintigraphy images were acquired following injection of 99mTc-HMPAO or 99mTc-duramycin. For hyperoxiarats, 99mTc-HMPAO and 99mTc-duramycin lung uptake increased in a time-dependent manner, reaching a maximum increase of 270% and 150% at 60 h, respectively. These increases were reduced to 120% and 70%, respectively, in hyperoxia+H2 rats. Hyperoxia exposure increased glutathione content in lung homogenate (36%) more than hyperoxia+H2 (21%), consistent with increases measured in 99mTc-HMPAO lung uptake. In 60-h hyperoxia rats, pleural effusion, which was undetectable in normoxia rats, averaged 9.3 gram/rat, and lung tissue 3-nitrotyrosine expression increased by 790%. Increases were reduced by 69% and 59%, respectively, in 60-h hyperoxia+H2 rats. This study detects and tracks the anti-oxidant and anti-apoptotic properties of H2 therapy in vivo after as early as 24 h of hyperoxia exposure. The results suggest the potential utility of these SPECT biomarkers for in vivo assessment of key cellular pathways in the pathogenesis of ALI and for monitoring responses to therapies
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