Family Companionship and Elderly Suicide: Evidence from the Chinese Lunar New Year

Mental health problems among the elderly have attracted increasing attention. The most serious mental health problems may result in suicide, and lack of family companionship is often speculated to be a major cause. In this paper, we use high-frequency suicide rate data and utilize a novel temporal variation in the lunisolar calendar to provide evidence on the protective effects of the Chinese Lunar New Year (when the elderly people receive unusually high level of family companionship) on elderly suicide. We find that elderly suicide rate decreases by 8.7% during the Chinese Lunar New Year. In addition, the protective effects are stronger in counties where the typical level of daily family companionship for the elderly is lower. By contrast, we do not find similar protective effects for young and middle-age cohorts. We consider a variety of alternative mechanisms, and conclude that family companionship is an important channel for the protective effects of the Chinese Lunar New Year. Our study calls for greater attention to the mental health status and suicide problem of the elderly, especially with the rapid population aging and increasing prevalence of the “empty-nest” elderly in developing countries

Local Lung Targeting of Tumor Associated Macrophages Combined with Cytoreductive Therapy Decrease Tumor Burden in a Secondary Lung Cancer Model

Backgrounds. The efficacy of a locally administered small molecule colony stimulating factor 1 receptor inhibitor (CSF-1Ri), PLX3397, alone or in combination with cytoreductive therapy (paclitaxel) in reducing the tumor burden of an in vivo model of secondary lung cancer was investigated in this work. Local administration of immunotherapy to the lungs may enhance lung biodistribution of such therapies and reduce potential unwanted off-target toxicity. In addition, combination of such therapy with low dose standard of care chemotherapy may offer improved anti-tumor effects. Methods. Murine breast cancer cells (4T1, known to be highly metastasized to the lungs) were transduced to express the genes luciferase and tdTomato, and cells were injected to female Balb/c mice before being treated with PLX (intratracheally administered), paclitaxel (intravenously given), or the combination therapy. Both ex vivo bioluminescent imaging and lung weights were used to evaluate tumor burden. Western blot was performed using lung tumors to assess the effect of PLX3397 on its molecular target (phosphorylated CSF-1R). Immunofluorescence and Flowcytometry were utilized to examine the impact of treatment on tumorigenic tumor associated macrophages (M2 TAM). Results. Single-agent treatment partially decreased tumor burden, while combination therapy led to a significant reduction in tumor burden. PLX3397 significantly inhibited the expression of phosphorylated CSF-1R and reduced the number of M2 TAM without affecting the total macrophage population, thereby increasing the anti-tumorigenic (M1)/M2 ratio. Conclusion. Tumor burden reduction upon local administration of PLX3397 to the lungs correlates with the marked inhibition of the molecular target and the decrease in M2 TAM.https://scholarscompass.vcu.edu/gradposters/1065/thumbnail.jp

Distributed Reconstruction via Alternating Direction Method

With the development of compressive sensing theory, image reconstruction from few-view projections has received considerable research attentions in the field of computed tomography (CT). Total-variation- (TV-) based CT image reconstruction has been shown to be experimentally capable of producing accurate reconstructions from sparse-view data. In this study, a distributed reconstruction algorithm based on TV minimization has been developed. This algorithm is very simple as it uses the alternating direction method. The proposed method can accelerate the alternating direction total variation minimization (ADTVM) algorithm without losing accuracy

A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility

PurposeIschemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility.MethodsA total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001).ConclusionOur study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS

3D Alternating Direction TV-Based Cone-Beam CT Reconstruction with Efficient GPU Implementation

Iterative image reconstruction (IIR) with sparsity-exploiting methods, such as total variation (TV) minimization, claims potentially large reductions in sampling requirements. However, the computation complexity becomes a heavy burden, especially in 3D reconstruction situations. In order to improve the performance for iterative reconstruction, an efficient IIR algorithm for cone-beam computed tomography (CBCT) with GPU implementation has been proposed in this paper. In the first place, an algorithm based on alternating direction total variation using local linearization and proximity technique is proposed for CBCT reconstruction. The applied proximal technique avoids the horrible pseudoinverse computation of big matrix which makes the proposed algorithm applicable and efficient for CBCT imaging. The iteration for this algorithm is simple but convergent. The simulation and real CT data reconstruction results indicate that the proposed algorithm is both fast and accurate. The GPU implementation shows an excellent acceleration ratio of more than 100 compared with CPU computation without losing numerical accuracy. The runtime for the new 3D algorithm is about 6.8 seconds per loop with the image size of 256×256×256 and 36 projections of the size of 512×512

Observation of high-temperature superconductivity in the high-pressure tetragonal phase of La2PrNi2O7-{\delta}

The recent discovery of high-temperature superconductivity in the Ruddlesden-Popper phase La3Ni2O7 under high pressure marks a significant breakthrough in the field of 3d transition-metal oxide superconductors. For an emerging novel class of high-Tc superconductors, it is crucial to find more analogous superconducting materials with a dedicated effort toward broadening the scope of nickelate superconductors. Here, we report on the observation of high-Tc superconductivity in the high-pressure tetragonal I4/mmm phase of La2PrNi2O7 above ~10 GPa, which is distinct from the reported orthorhombic Fmmm phase of La3Ni2O7 above 14 GPa. For La2PrNi2O7, the onset and the zero-resistance temperatures of superconductivity reach Tconset = 78.2 K and Tczero = 40 K at 15 GPa. This superconducting phase shares the samilar structural symmetry as many cuprate superconductors, providing a fresh platform to investigate underlying mechanisms of nickelate superconductors.Comment: 19 pages and 6 figure

ENHANCING CHEMOSENSITIVITY OF LUNG CANCERS BY MANIPULATING THE TUMOR MICROENVIRONMENT: LOCAL LUNG DELIVERY AND NANOCARRIER-BASED THERAPIES

Cancer is the second leading cause of death in United States causing an estimated six hundred thousand death in 2019. Among different types of cancer, lung cancer is the leading cause of cancer related death in both male and female. While targeted therapy and immunotherapy have shown promising clinical outcomes, currently there remain a significant proportion of patients who do not benefit from these strategies or who cannot tolerate them, making Pt based doublet chemotherapy still an indispensable component in almost all stages of treatment. However, partially due to the poor tumor distribution of small molecule drug, the development of drug resistance and the severe toxicity, its clinical benefits was not obvious, and the increase in survival rate of lung cancer patients in the past 5 decades was still limited. In last decades, the concept of immunotherapy was widely accepted and was considered as the next era for cancer treatment. Tumor associate macrophage (TAM), a major component of the leukocyte infiltrate that is present in almost all tumors, have a dominant role as orchestrators of cancer-related inflammation that can finally determine the effectiveness of the treatment. Clinical evidence indicates that there is a positive correlation between the survival rate and the M1/M2 ratio in the tumor of non-small cell lung cancer patient. Thus, it will be promising to enhance the treatment outcome by increasing the M1/M2 ratio. In this work, a combination of local lung targeting (to increase the local drug concentration while minimize its systemic exposure), biodegradable nanocarriers (an upgrade for the rigid dendrimer to modulate interactions with physiological environment), chemotherapy (first line treatment for late stage lung cancer) and macrophage repolarization immunotherapy (to modulate the tumor microenvironment) are reported. We describe the development of a surface modified polyester dendrimer nanocarriers as a platform for the delivery of platinum based chemotherapeutics, the development of a highly reliable and reproducible animal model, the evaluation of the efficacy of dendrimer-platinum nanoconjugate both in vitro and in vivo, and the evaluation of a combination regimen of systemically delivery of chemotherapy with pulmonary delivery of tumor associated macrophage (TAM) targeting immunomodulator. Overall, we conclude that all these strategies described above have the potential translational capability to enhance the current standard of care for the lung cancer patients