To Achieve Security and High Spectrum Efficiency: A New Transmission System Based on Faster-than-Nyquist and Deep Learning

With the rapid development of various services in wireless communications, spectrum resource has become increasingly valuable. Faster-than-Nyquist (FTN) signaling, which was proposed in the 1970s, has been a promising paradigm to improve the spectrum utilization. In this paper, we try to apply FTN into secure communications and propose a secure and high-spectrum-efficiency transmission system based on FTN and deep learning (DL). In the proposed system, the hopping symbol packing ratio with random values makes it difficult for the eavesdropper to obtain the accurate symbol rate and inter-symbol interference (ISI). While the receiver can use the blind estimation to choose the true parameters with the aid of DL. The results show that without the accurate symbol packing ratio, the eavesdropper will suffer from severe performance degradation. As a result, the system can achieve a secure transmission with a higher spectrum efficiency. Also, we propose a simplified symbol packing ratio estimation which has bee employed in our proposed system. Results show that the proposed simplified estimation achieves nearly the same performance as the original structure while its complexity has been greatly reduced

Modified Cramer-Rao bound for M-FSK signal parameter estimation in Cauchy and Gaussian noise

The Cramer-Rao bound (CRB) provides an efficient standard for evaluating the quality of standard parameter estimators. In this paper, a modified Cramer-Rao bounds (MCRB) for modulation parameter estimations of frequency-shift-keying (FSK) signals is proposed under the condition of the Gaussian and non-Gaussian additive interference. We extend the MCRB to the estimation of a vector of non-random parameters in the presence of nuisance parameters. Moreover, the MCRB is applied to the joint estimation of phase offset, frequency offsets, frequency deviation, and symbol period of FSK signal with two important special cases of alpha stable distributions, namely, the Cauchy and the Gaussian. The extensive simulation studies are conducted to contrast the MCRB for the modulation parameter vector in different noise environments

Blind parameter estimation of M-FSK signals in the presence of alpha-stable noise

Blind estimation of parameters for M-ary frequency-shift-keying (M-FSK) signals is great of importance in intelligent receivers. Many existing algorithms have assumed white Gaussian noise. However, their performance severely degrades when grossly corrupted data, i.e., outliers, exist. This paper solves this issue by developing a novel approach for parameter estimation of M-FSK signals in the presence of alpha-stable noise. Specifically, the proposed method exploits the generalized first- and second-order cyclostationarity of M-FSK signals with alpha-stable noise, which results in closed-form solutions for unknown parameters in both time and frequency domains. As a merit, it is computationally efficient and thus can be used for signal preprocessing, symbol timing estimation, signal and noise power estimation. Furthermore, substantial theoretical analysis on the performance of the proposed approach is provided. Simulations demonstrate that the proposed method is robust to alpha-stable noise and that it outperforms the state-of-the-art algorithms in many challenging scenarios

Reliable detection of transmit-antenna number for MIMO systems in cognitive radio-enabled Internet of Things

Identification of transmit-antenna number is of importance in cognitive Internet of Things with multiple-input multiple-output (MIMO). Previous studies on transmit-antenna number detection only consider Gaussian noise and ignore impulsive interference. In the practical wireless communication, impulsive interference may exist due to low-frequency atmospheric noise, multiple access and electromagnetic disturbance. Such interference can usually be modeled as symmetric alpha stable (SαS), which cause the performance degradation of conventional algorithms based on Gaussian model. In this paper, we present a novel scheme to detect the transmit-antenna number for MIMO systems in cognitive Internet of Things, assuming that signals are corrupted by both SαS interference and Gaussian noise. We first introduce a new approach to characterize the generalized correlation matrix, and provide its bound with SαS interference. Then, the discriminating feature vector is constructed by utilizing the higher-order moments (HOM) of eigenvalues of the generalized correlation matrix. Finally, an advanced clustering algorithm is employed to detect the transmit-antenna number, using the cluster where the minimum eigenvalue is located. The proposed algorithm avoids the need for a priori information about the transmitted signals, such as coding mode, modulation type and pilot patterns. Simulation experiments demonstrate the feasibility of the proposed transmit-antenna number detection scheme in MIMO systems with Gaussian noise and SαS interference

Pharmacokinetics of single- and multiple-dose flumatinib in patients with chronic phase chronic myeloid leukemia

IntroductionFlumatinib is a novel, oral breakpoint cluster region-abelson (BCR-ABL) tyrosine kinase inhibitor that has demonstrated manageable safety and promising efficacy in patients with newly diagnosed chronic phase (CP) chronic myeloid leukemia (CML). MethodsThis study evaluated the pharmacokinetic (PK) profiles of flumatinib mesylate tablets at a dose of 400 mg and 600 mg in patients with CML-CP. The study was registered at chictr.org Identifier (ChiCTR2100044700). In this open-label, pharmacokinetic study, eligible patients were administered a single-dose of flumatinib 400 mg or 600 mg on day 1, followed by 2-day washout and 8 consecutive days of once-daily administration. Serial plasma samples were assayed for flumatinib and its metabolites (N-demethylate metabolite M1 and amide-bond hydrolytic metabolite M3).ResultsTwenty-nine patients were assigned to flumatinib 400 mg (n=14) or 600 mg (n=15). Serum concentrations of flumatinib reached maximum measured plasma concentration (Cmax) at a median time of 2 hours after each single dose, and then eliminated slowly with a mean apparent terminal disposition half-life (t1/2) from 16.0 to 16.9 hours. Following single- and multiple-dose administration, flumatinib exposure (Cmax, area under the concentration-time curve from 0 to t hours (AUC0-t), area under the concentration-time curve from 0 hours to infinity (AUC0-∞)) increased in an approximately dose-proportional manner. There was approximately 4.1- and 3.4- fold drug accumulation at steady-state after multiple-dose administration at 400 mg and 600 mg, respectively. The drug-related AEs associated with both treatments were primarily low-grade and tolerable events.ConclusionAnalysis of PK parameters indicated that flumatinib exposure increased in an approximately dose-proportional manner. Further research needs to be conducted in a large sample-size study

Transmit antenna number identification for MIMO cognitive radio systems in the presence of Alpha-Stable noise

Identification of communication parameters, a major task of intelligent receivers, has important applications in intelligent systems, especially cognitive radio systems. Multiple antennas make the identification problem more challenging. In this paper, we focus on the problem of detecting the number of transmit antennas in multiple-input multiple-output (MIMO) cognitive radio systems. A novel identification algorithm is proposed to determine the number of transmit antennas for MIMO systems in the presence of alpha-stable noise. We first introduce the correlation matrix based on the fractional lower order statistics (FLOS) and provide a particular structure of FLOS-based correlation matrix. Then, the eigenvalues of the FLOS-based correlation matrix are employed to construct a test statistic and the central limit theorem is exploited to obtain the decision threshold. Finally, the transmit-antenna number is detected using a serial binary hypothesis test. Simulation results are demonstrated to evaluate the effectiveness of the proposed transmit-antenna number detection algorithm for MIMO systems in the presence of alpha-stable noise

P783 Clinical, Humanistic, and Economic Burden in Patients with PNH Receiving C5 Inhibition Treatment across UK, Germany, and France. Insights from the Commodore Burden of Illness Study

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening blood disorder. In the UK, Germany, and France, C5 complement inhibitors, such as eculizumab and ravulizumab, both of which are intravenously (IV) infused, are the standard of care for PNH