Cosmology-Independent Distance Moduli of 42 Gamma-Ray Bursts between Redshift of 1.44 and 6.60

This report is an update and extension of our paper accepted for publication in ApJ (arXiv:0802.4262). Since objects at the same redshift should have the same luminosity distance and the distance moduli of type Ia supernovae (SNe Ia) obtained directly from observations are completely cosmology independent, we obtain the distance modulus of a gamma-ray burst (GRB) at a given redshift by interpolating or iterating from the Hubble diagram of SNe Ia. Then we calibrate five GRB relations without assuming a particular cosmological model, from different regression methods, and construct the GRB Hubble diagram to constrain cosmological parameters. Based upon these relations we list the cosmology-independent distance moduli of 42 GRBs between redshift of 1.44 and 6.60, with the 1-$\sigma$ uncertainties of 1-3%.Comment: 6 pages, 2 figures, 3 tables. To appear in the proceedings of "2008 Nanjing GRB conference", Nanjing, 23-27 June 200

Extended Emission of Short Gamma-Ray Bursts

Preliminary results of our analysis on the extended emission of short/medium duration GRBs observed with Swift/BAT are presented. The Bayesian blocks algorithm is used to analyze the burst durations and the temporal structure of the lightcurves in different energy bands. We show here the results of three bursts (GRBs 050724, 061006 and 070714B) that have a prominent soft extended emission component in our sample. The extended emission of these bursts is a continuous, flickering-liked component, lasting $\sim 100$ seconds post the GRB trigger at 15-25 keV bands. Without considering this component, the three bursts are classified as short GRBs, with $T_{90}=2\sim 3$ seconds. GRB 060614 has an emission component similar to the extended emission, but this component has pulse-liked structure, possibly indicating that this emission component is different from that observed in GRBs 050724, 061006, and 070714B. Further analysis on the spectral evolution behavior of the extended emission component is on going.Comment: 2008 Nanjing GRB Conferenc

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation.

Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation (PARylation). Here we explore chemical and chemoenzymatic synthesis of NAD+ analogues with ribose functionalized by terminal alkyne and azido groups. Our results demonstrate that azido substitution at 3'-OH of nicotinamide riboside enables enzymatic synthesis of an NAD+ analogue with high efficiency and yields. Notably, the generated 3'-azido NAD+ exhibits unexpected high activity and specificity for protein PARylation catalyzed by human poly-ADP-ribose polymerase 1 (PARP1) and PARP2. And its derived poly-ADP-ribose polymers show increased resistance to human poly(ADP-ribose) glycohydrolase-mediated degradation. These unique properties lead to enhanced labeling of protein PARylation by 3'-azido NAD+ in the cellular contexts and facilitate direct visualization and labeling of mitochondrial protein PARylation. The 3'-azido NAD+ provides an important tool for studying cellular PARylation

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate.

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration. However, the development and heterogeneity of AT1 cells remain largely unknown. Here, we conducted a single-cell RNA-seq analysis to characterize postnatal AT1 cell development and identified insulin-like growth factor-binding protein 2 (Igfbp2) as a genetic marker specifically expressed in postnatal AT1 cells. The portion of AT1 cells expressing Igfbp2 increases during alveologenesis and in post pneumonectomy (PNX) newly formed alveoli. We found that the adult AT1 cell population contains both Hopx+Igfbp2+ and Hopx+Igfbp2- AT1 cells, which have distinct cell fates during alveolar regeneration. Using an Igfbp2-CreER mouse model, we demonstrate that Hopx+Igfbp2+ AT1 cells represent terminally differentiated AT1 cells that are not able to transdifferentiate into AT2 cells during post-PNX alveolar regeneration. Our study provides tools and insights that will guide future investigations into the molecular and cellular mechanism or mechanisms underlying AT1 cell fate during lung development and regeneration

Radial Angular Momentum Transfer and Magnetic Barrier for Short-Type Gamma-Ray Burst Central Engine Activity

Soft extended emission (EE) following initial hard spikes up to 100 seconds was observed with {\em Swift}/BAT for about half of short-type gamma-ray bursts (SGRBs). This challenges the conversional central engine models of SGRBs, i.e., compact star merger models. In the framework of the black hole-neutron star merger models, we study the roles of the radial angular momentum transfer in the disk and the magnetic barrier around the black hole for the activity of SGRB central engines. We show that the radial angular momentum transfer may significantly prolong the lifetime of the accretion process and multiple episodes may be switched by the magnetic barrier. Our numerical calculations based on the models of the neutrino-dominated accretion flows suggest that the disk mass is critical for producing the observed EE. In case of the mass being $\sim 0.8M_{\odot}$, our model can reproduce the observed timescale and luminosity of both the main and EE episodes in a reasonable parameter set. The predicted luminosity of the EE component is lower than the observed EE with about one order of magnitude and the timescale is shorter than 20 seconds if the disk mass being $\sim 0.2M_{\odot}$. {\em Swift}/BAT-like instruments may be not sensitive enough to detect the EE component in this case. We argue that the EE component would be a probe for merger process and disk formation for compact star mergers.Comment: 9 pages, 3 figures, accepted for publication in Ap