Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis

During embryogenesis, morphogens form a concentration gradient in responsive tissue, which is then translated into a spatial cellular pattern. The mechanisms by which morphogens spread through a tissue to establish such a morphogenetic field remain elusive. Here, we investigate by mutually complementary simulations and in vivo experiments how Wnt morphogen transport by cytonemes differs from typically assumed diffusion-based transport for patterning of highly dynamic tissue such as the neural plate in zebrafish. Stochasticity strongly influences fate acquisition at the single cell level and results in fluctuating boundaries between pattern regions. Stable patterning can be achieved by sorting through concentration dependent cell migration and apoptosis, independent of the morphogen transport mechanism. We show that Wnt transport by cytonemes achieves distinct Wnt thresholds for the brain primordia earlier compared with diffusion-based transport. We conclude that a cytoneme-mediated morphogen transport together with directed cell sorting is a potentially favored mechanism to establish morphogen gradients in rapidly expanding developmental systems

Smart city pilots, marketization processes, and substantive green innovation: A quasi-natural experiment from China.

The world's major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government's smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007-2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation

The trend of green utility model patents.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div

Variable names and definitions.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div

Baseline results.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div

Regression results of threshold model.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div

The test of threshold effect.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div

Regression results of PSM-DID.

The world’s major economies are striving to control carbon emissions and avoid irreversible impacts on the natural environment. Therefore, innovative green technologies are crucial for both government departments and the private sector as an important way to address carbon emissions. This study aims to investigate the link between the government’s smart city construction and corporate green innovation and optimize the policy guidelines that drive green innovation in enterprises. This study analyzes 6,104 panels of Chinese listed companies from 2007–2019. An approach called the Differences-in-Differences model was applied to evaluate hypotheses. The empirical results suggest that smart city pilots drove substantial green innovation in businesses. The marketization process has a moderating effect on the impact of smart city pilots on substantive green innovation in enterprises. Moreover, marketization process has a threshold effect in smart city pilots influencing the substantive green innovation of enterprises, and the effect of smart city drivers influencing the substantive green innovation of enterprises increases significantly when regional marketization process reaches a certain level. The findings of this study provide valuable guidance for policy designers to promote corporate green innovation at both the hardware facility level and the market system level of cities when developing policies related to green innovation.</div