Serum Zinc-α2-Glycoprotein Levels Were Decreased in Patients With Premature Coronary Artery Disease

Objectives: To explore serum zinc-α2-glycoprotein (ZAG) changes in patients with or without premature coronary artery disease (PCAD) and its association with several cardiovascular risk factors.Methods: A total of 3,364 patients who were undergone coronary angiography in Peking Union Medical College Hospital were screened. According to the degree of coronary artery stenosis, the number of 364 patients with PCAD (age <55 years in males and <65 years in females) and 126 age and gender matched patients without premature coronary artery disease (NPCAD) were recruited in our present study. In addition, 182 age and gender matched healthy controls were also enrolled. Serum ZAG levels were determined by enzyme-linked immunosorbent assay (ELISA) method.Results: Serum ZAG were significantly lower in the PCAD (8.03 ± 1.01 vs. 8.78 ± 1.89 μg/mL, p < 0.05) and NPCAD groups (8.28 ± 1.61 vs. 8.78 ± 1.89 μg/mL, p < 0.05), respectively, when compared with the controls. Multiple regression analysis showed that PCAD was independently associated with serum ZAG levels (B = −0.289, p = 0.002). The probability of PCAD in subjects with low tertile ZAG levels was 2.48-fold higher than those with high tertile levels after adjusting for other confounders [OR = 3.476, 95% CI 1.387–8.711, p = 0.008]. This phenomenon was more likely to be observed in male subjects with BMI <24 kg/m2. The receiver operating curve (ROC) analysis showed a weak diagnostic performance of serum ZAG for PCAD (AUC = 0.659, 95% CI 0.612–0.705, p < 0.05). At the cutoff value of 7.955 μg/mL serum ZAG, the sensitivity and specificity for differentiating patients with PCAD from controls were 50.5 and 78.0%, respectively. The combination of ZAG with other clinical variables including age, gender, BMI, SBP, FBG, TC, HDL-C, Cr, and Urea had significantly improved the diagnosis accuracy with a sensitivity of 82.6%, a specificity of 95.0%, and AUC of 0.957 (95% CI, 0.940–0.975, p < 0.05).Conclusion: Serum ZAG levels were firstly found to be decreased in Chinese PCAD patients. Subjects with lower ZAG levels were more likely to have PCAD, especially for male subjects with BMI <24 kg/m2. ZAG might be the potential diagnostic biomarkers for PCAD patients, and the combination of ZAG and clinical variables had higher discriminative performance

GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers

Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in the Han Chinese population. 523,663 autosomal SNPs in 1,538 HBV–positive HCC patients and 1,465 chronic HBV carriers were genotyped for the discovery stage. Top candidate SNPs were genotyped in the initial validation samples of 2,112 HBV–positive HCC cases and 2,208 HBV carriers and then in the second validation samples of 1,021 cases and 1,491 HBV carriers. We discovered two novel associations at rs9272105 (HLA-DQA1/DRB1) on 6p21.32 (OR = 1.30, P = 1.13×$10^{−19}$) and rs455804 (GRIK1) on 21q21.3 (OR = 0.84, P = 1.86×$10^{−8}$), which were further replicated in the fourth independent sample of 1,298 cases and 1,026 controls (rs9272105: OR = 1.25, P = 1.71×$10^{−4}$; rs455804: OR = 0.84, P = 6.92×$10^{−3}$). We also revealed the associations of HLA-DRB1*0405 and 0901*0602, which could partially account for the association at rs9272105. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV–related HCC, suggesting the involvement of glutamate signaling in the development of HBV–related HCC

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A New 4D Piecewise Linear Multiscroll Chaotic System with Multistability and Its FPGA-Based Implementation

Due to the complex behavior of a multiscroll chaotic system, it is a good candidate for the secure communications. In this paper, by adding an additional variable to the modified Lorenz-type system, a new chaotic system that includes only linear and piecewise items but can generate 4n + 4 scroll chaotic attractors via choosing the various values of natural number n is proposed. Its dynamics including bifurcation, multistability, and symmetric coexisting attractors, as well as various chaotic and periodic behaviors, are analyzed by means of attraction basin, bifurcation diagram, dynamic map, phase portrait, Lyapunov exponent spectrum, and C0 complexity in detail. The mechanism of the occurrence for generating multiscroll chaotic attractors is presented. Finally, this multiscroll chaotic system is implemented by using the Altera Cyclone IV EP4CE10F17C8 FPGA. It is found that this FPGA-based design has an advantage of requiring less resources for 0% of the embedded multipliers and 0% of the PLLs of this FPGA are occupied

A High Quality-Factor Optical Modulator with Hybrid Graphene-Dielectric Metasurface Based on the Quasi-Bound States in the Continuum

In this paper, we combine the dielectric metasurface with monolayer graphene to realize a high quality(Q)-factor quasi-BIC-based optical modulator, and the corresponding modulation performances are investigated by using the finite-difference time-domain (FDTD) method, which can be well fitting by the Fano formula based on the temporal couple-mode theory. The results demonstrate that bound states in the continuum (BIC) will turn into the quasi-BIC with high Q-factor by breaking the symmetry of every unit of the metasurface. Meanwhile, the amplitude and bandwidth of transmission based on the quasi-BIC mode can be efficiently adjusted by changing the Fermi energy (EF) of monolayer graphene, and the maximum difference in transmission up to 0.92 is achieved. Moreover, we also discuss the influence of the asymmetry degree to further investigate the modulation effect of graphene on the quasi-BIC mode

How Can Cities Adapt to a Multi-Disaster Environment? Empirical Research in Guangzhou (China)

Urban disaster risk assessment is the most basic and important part of urban safety development. Conducting disaster prevention and mitigation on the basis of urban disaster risk assessment requires an understanding of the relationship between the city and the natural environment. This enhances the city’s ability to withstand various types of disasters and achieves the development of a safe city. Based on a review of the existing literature, we propose a fuzzy comprehensive evaluation method for urban multi-disaster risk assessment. The multi-disaster risk assessment method includes the identification and screening of urban disasters, the assessment of individual disaster risk, and integrated urban disaster risks, the division of urban comprehensive disaster risks into several risk levels, and the determination of coping strategies. Taking Guangzhou (China) as an example, we determined the major disaster risks faced by Guangzhou, assessed the risks of individual disasters, and finally obtained the results of the comprehensive disaster risk of Guangzhou. Second, we analyzed the relationship between the disaster risk assessment and urban safety development, and proposed countermeasures and recommendations for the development of different disaster risk levels

Identifying Forest Degradation and Restoration Opportunities in the Lancang-Mekong Region: A Tool to Determine Criteria and Indicators

Forest restoration is increasingly becoming a priority at international and national levels. Identifying forest degradation, however, is challenging because its drivers are underlying and site-specific. Existing frameworks and principles for identifying forest degradation are useful at larger scales, however, a framework that includes iterative input from local knowledge-holders would be useful at smaller scales. Here, we present a new mechanism; a framework for developing criteria and indicators that enables an approach for the identification of forest degradation and opportunities for restoration in landscapes that is free from failures that are often inherent to project cycles. The Degradation and Restoration Assessment Mechanism (DReAM) uses an iterative process that is based on local expertise and established regional knowledge to inform what is forest degradation and how to monitor restoration. We tested the mechanism’s utility at several sites in the Lancang-Mekong Region (Cambodia, Laos, Myanmar, Thailand, and Vietnam). The application of this mechanism rendered a suite of appropriate criteria and indicators for use in identifying degraded forests which can help inform detailed guidelines to develop rehabilitation approaches. The mechanism is designed to be utilized by any individual or group that is interested in degradation identification and/or rehabilitation assessment.Forestry, Faculty ofNon UBCReviewedFacultyResearche

Secondary recrystallization of {310}<001> texture and enhanced magnetostriction in Fe–Ga alloy thin sheet

Sharp {310} texture and enhanced magnetostriction were achieved in Fe–Ga thin sheets by secondary recrystallization. The evolution of texture, inhibitor, and magnetostriction of Fe–Ga thin sheet during the annealing process were analyzed. A fine and homogeneous microstructure with a strong γ-fiber and weak Goss and {310} texture was produced. Goss and {310} texture did not exhibit any advantage in terms of the grain size and number over the matrix grains in the primary recrystallization, but {310} texture is superior to Goss texture in grain size and number. Statistical results show that a large number of MnS and NbC precipitates with the size range of 20–140 nm dispersedly distributed in the primary matrix grains thus inhibiting the normal grain growth of primary grains sufficiently. The microstructure and texture evolution during the annealing process indicates that the secondary recrystallization of {310} texture is related to the combination of grain size, quantity, and high energy grain boundary characteristic of {310} texture. The secondary recrystallization of {310} texture is conducive to the improvement of the magnetostrictive coefficient and a maximum magnetostriction of 240 ppm was obtained in Fe–Ga thin sheet after final annealing