Beyond Triplet: Leveraging the Most Data for Multimodal Machine Translation

Multimodal machine translation (MMT) aims to improve translation quality by incorporating information from other modalities, such as vision. Previous MMT systems mainly focus on better access and use of visual information and tend to validate their methods on image-related datasets. These studies face two challenges. First, they can only utilize triple data (bilingual texts with images), which is scarce; second, current benchmarks are relatively restricted and do not correspond to realistic scenarios. Therefore, this paper correspondingly establishes new methods and new datasets for MMT. First, we propose a framework 2/3-Triplet with two new approaches to enhance MMT by utilizing large-scale non-triple data: monolingual image-text data and parallel text-only data. Second, we construct an English-Chinese {e}-commercial {m}ulti{m}odal {t}ranslation dataset (including training and testing), named EMMT, where its test set is carefully selected as some words are ambiguous and shall be translated mistakenly without the help of images. Experiments show that our method is more suitable for real-world scenarios and can significantly improve translation performance by using more non-triple data. In addition, our model also rivals various SOTA models in conventional multimodal translation benchmarks.Comment: 8 pages, ACL 2023 Findin

Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases

Purpose: To determine the association between Cystatin C (Cys C) levels and the interaction of pulmonary tuberculosis (PTB) with chronic diseases (CD).Methods: Participants (n = 356) were selected randomly from The First Affiliated Hospital of Wannan Medical College, China, and divided into 4 groups: normal control group (n = 80), PTB group (n = 98), chronic disease group (n = 146), and PTB combined with chronic disease group (PTB+CD, n = 31). The investigation included information on demographics and analysis of blood samples for Cys C, liver function, renal function, blood glucose and other biochemical indices.Results: The highest level of Cys C was obtained in PTB + CD group. Before and after adjusting eGFR, there was no association between Cys C and PTB or/and chronic disease. However abnormal levels of Cys C were significantly higher in PTB+CD group after adjusting eGFR (OR = 4.014, p = 0.0125).Conclusion: Higher levels of Cys C may be associated with chronic diseases co existing with PTB.Keywords: Cystatin C, Pulmonary tuberculosis, Chronic diseases, Inflammatio

Evaluating approximate asymptotic distributions for fast neutrino flavor conversions in a periodic 1D box

The fast flavor conversions (FFCs) of neutrinos generally exist in core-collapse supernovae and binary neutron-star merger remnants, and can significantly change the flavor composition and affect the dynamics and nucleosynthesis processes. Several analytical prescriptions were proposed recently to approximately explain or predict the asymptotic outcome of FFCs for systems with different initial or boundary conditions, with the aim for providing better understandings of FFCs and for practical implementation of FFCs in hydrodynamic modeling. In this work, we obtain the asymptotic survival probability distributions of FFCs in a survey over thousands of randomly sampled initial angular distributions by means of numerical simulations in one-dimensional boxes with the periodic boundary condition. We also propose improved prescriptions that guarantee the continuity of the angular distributions after FFCs. Detailed comparisons and evaluation of all these prescriptions with our numerical survey results are performed. The survey dataset is made publicly available to inspire the exploration and design for more effective methods applicable to realistic hydrodynamic simulations.Comment: 15 pages, 5 figure

A curve model for association of serum homocysteine with carotid artery hemodynamics

Purpose: To investigate the correlation between carotid artery hemodynamics and serum homocysteine.Methods: A total of 894 participants made up of 439 male (49.11 %) and 455 female (50.89 %) from Ma’anshan, China, enrolled in the cross-sectional study. Data collection included demographics, blood sample and carotid ultrasonography. Piecewise linear regression analysis was used to analyze the relationship between serum homocysteine and carotid artery hemodynamics.Results: Homocysteine (Hcy) levels were divided into four groups by quartiles. The populations of the groups were 226, 220, 222, 226; and their mean ages were 56.52 ± 10.49, 62.27 ± 10.06, 63.42 ± 9.81 and 65.38 ± 10.56 years, respectively. After adjustment for blood biochemical and demographics factors, U-shaped and S-shaped curves were as observed between Hcy and carotid artery hemodynamics. The adjusted regression analysis showed that the threshold values of Hcy with end diastolic velocity (EDV) of right common carotid artery (CCA) were 12.50 and 19.00, while for the EDV of right internal carotid artery (ICA), the values were 11.50 and 22.00. U-shaped curves were observed between Hcy and peak systolic velocity (PSV) of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA. The threshold values of Hcy with PSV of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA were 14.00, 14.00, 14.00 and 13.50, respectively.Conclusion: These results indicate that a significant correlation exists between homocysteine at different concentrations and carotid artery hemodynamics.Keywords: Homocysteine, Hemodynamics, End diastolic velocity, Peak systolic velocit

A highly robust and optimized sequence-based approach for genetic polymorphism discovery and genotyping in large plant populations

KEY MESSAGE: This optimized approach provides both a computational tool and a library construction protocol, which can maximize the number of genomic sequence reads that uniformly cover a plant genome and minimize the number of sequence reads representing chloroplast DNA and rRNA genes. One can implement the developed computational tool to feasibly design their own RAD-seq experiment to achieve expected coverage of sequence variant markers for large plant populations using information of the genome sequence and ideally, though not necessarily, information of the sequence polymorphism distribution in the genome. ABSTRACT: Advent of the next generation sequencing techniques motivates recent interest in developing sequence-based identification and genotyping of genome-wide genetic variants in large populations, with RAD-seq being a typical example. Without taking proper account for the fact that chloroplast and rRNA genes may occupy up to 60 % of the resulting sequence reads, the current RAD-seq design could be very inefficient for plant and crop species. We presented here a generic computational tool to optimize RAD-seq design in any plant species and experimentally tested the optimized design by implementing it to screen for and genotype sequence variants in four plant populations of diploid and autotetraploid Arabidopsis and potato Solanum tuberosum. Sequence data from the optimized RAD-seq experiments shows that the undesirable chloroplast and rRNA contributed sequence reads can be controlled at 3–10 %. Additionally, the optimized RAD-seq method enables pre-design of the required uniformity and density in coverage of the high quality sequence polymorphic markers over the genome of interest and genotyping of large plant or crop populations at a competitive cost in comparison to other mainstream rivals in the literature. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00122-016-2736-9) contains supplementary material, which is available to authorized users

MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer

MicroRNAs (miRNAs) have recently been recognized as targets for anti-metastatic therapy against cancer malignancy. Development of effective miRNA mediated therapies remains a challenge to both basic research and clinical practice. Here we presented the evidence for a miR-708-5p mediated replacement therapy against metastatic lung cancer. Expression of miR-708-5p was substantially reduced in metastatic lung cancer samples and cancer cell lines when compared to non-metastatic counterparts. Expression of the miRNA suppressed cell survival and metastasis in vitro through its direct target p21, and inhibited the PI3K/AKT pathway and stem cell-like characteristics of lung cancer cells. Systemic administration of this miRNA in a mouse model of NSCLC using polyethylenimine (PEI)-mediated delivery of unmodified miRNA mimics induced tumor specific apoptosis. It also effectively protected the tested animals from developing metastatic malignancy without causing any observed toxicity. The findings strongly support miR-708-5p as a novel and effective therapeutic agent against metastatic malignancy of non-small cell lung cancer

Current therapy option for necrotizing enterocolitis: Practicalities and challenge

Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment

Review of Printed Electrodes for Flexible Devices

Printed electronic technologies draw tremendous attention worldwide due to their ability to surpass the limitations of traditional high-cost electronics, based on rigid silicon, and the manufacturing of various devices on flexible substrates. As a critical component of flexible electronics, electrodes fabricated on soft, bendable, and stretchable substrates are of great importance. Based on the fabrication process, this paper classifies the mainstream technologies into two categories: top-down and bottom-up. Top-down technologies include physical evaporation methods, printing technologies and soft lithography, while bottom-up technologies involve polymer-assisted-metal-deposition methods and ion-exchange methods, respectively. In contrast to top-down technologies that transfer functional ink onto substrates directly, the bottom-up method achieves a great improvement in the adhesion between substrates and metal electrodes. In this paper, the challenges of top-down technologies, including cost, synthesis, and choice of ink for printing technologies, the limited choice of metal for bottom-up technologies and the mass production of these methods, are also discussed