Organizational Analysis of Institutions for the Aged

Institutions for the aged represent an organized effort on the part of society and various individuals., groups, and organizations to provide for and capitalize on the service needs of elderly persons no longer able to live independently in the community. These settings have been brought into existence and are maintained by various commercial, civic, voluntary, government, and other interest groups. The motives and interests of such groups vary; nevertheless, these settings offer services to consumers, provide employment to members of various professional and occupational groups, provide an arena for the involvement of various scholastic disciplines and professional associations, and benefit individuals and families related to the residents who live temporarily or permanently in institutions or otherwise also utilize the services offered in such settings. Institutions for the aged provide opportunities for business profits, and involvement for legislative, administrative, and regulatory public agencies. Viewing institutions for the aged with an organizational analysis frame of reference, therefore, should enhance our understanding of the salient factors which facilitate or constrain the operation of such settings and the services provided which, in turn, affect the level of well-being of elderly and disabled persons utilizing these services on a temporary or permanent basis. Using organizational analysis as a guiding framework, a model for the comprehension and better understanding of institutions for the aged will be developed and discussed. In the gerontological literature, institutions for the aged include homes for the aged, nursing homes, domiciliaries, chronic care facilities, and other congregate care environments serving older persons unable to live independently in the community

Community Service Opportunities and Older Americans

Contemporary society has brought about a situation where older Americans have limited opportunities for contributory roles. They have limited involvement in the development and provision of services aimed to promote their own well-being and the welfare and well-being of others. This article examines the importance of contributory roles and functions in light of theoretical perspectives, social work values, and research evidence which indicates that life satisfaction and psychological well being of older persons is related to continued productivity and the opportunity to carry substantive social roles. This article reviews and discusses contributory opportunities for older persons as part of community service employment programs, sponsored volunteer programs, and associations of older persons and substantiates the benefits of these organized efforts for older Americans, sponsoring organizations, and service consumers. Continuation and expansion of contributory roles for older persons will improve the quality of their life, will reduce the extent to which they are considered a resource consuming national problem, and will contribute to the development of a conception which views older Americans as a valuable national resource

The Effects of the Holocaust: Psychiatric, Behavioral, and Survivor Perspectives

In this paper the authors review perspectives related to Holocaust victims, limitations of Holocaust studies are discussed, and suggestions for viewing the long-range post-traumatic effects of the Holocaust upon its victims from social and behavioral science perspectives are advanced. The views of survivors toward post-war adjustment, drawn from interviews with Holocaust victims, are also presented

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

A promising molecular target for aggressive cancers is the urokinase receptor (uPAR). A fully human, recombinant antibody that binds uPAR to form a stable complex that blocks uPA-uPAR interactions (2G10) and is internalized primarily through endocytosis showed efficacy in a mouse xenograft model of highly aggressive, triple negative breast cancer (TNBC). Antibody-drug conjugates (ADCs) of 2G10 were designed and produced bearing tubulin inhibitor payloads ligated through seven different linkers. Aldehyde tag technology was employed for linking, and either one or two tags were inserted into the antibody heavy chain, to produce site-specifically conjugated ADCs with drug-to-antibody ratios of either two or four. Both cleavable and non-cleavable linkers were combined with two different antimitotic toxins—MMAE (monomethylauristatin E) and maytansine. Nine different 2G10 ADCs were produced and tested for their ability to target uPAR in cell-based assays and a mouse model. The anti-uPAR ADC that resulted in tumor regression comprised an MMAE payload with a cathepsin B cleavable linker, 2G10-RED-244-MMAE. This work demonstrates in vitro activity of the 2G10-RED-244-MMAE in TNBC cell lines and validates uPAR as a therapeutic target for TNBC

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.

A promising molecular target for aggressive cancers is the urokinase receptor (uPAR). A fully human, recombinant antibody that binds uPAR to form a stable complex that blocks uPA-uPAR interactions (2G10) and is internalized primarily through endocytosis showed efficacy in a mouse xenograft model of highly aggressive, triple negative breast cancer (TNBC). Antibody-drug conjugates (ADCs) of 2G10 were designed and produced bearing tubulin inhibitor payloads ligated through seven different linkers. Aldehyde tag technology was employed for linking, and either one or two tags were inserted into the antibody heavy chain, to produce site-specifically conjugated ADCs with drug-to-antibody ratios of either two or four. Both cleavable and non-cleavable linkers were combined with two different antimitotic toxins-MMAE (monomethylauristatin E) and maytansine. Nine different 2G10 ADCs were produced and tested for their ability to target uPAR in cell-based assays and a mouse model. The anti-uPAR ADC that resulted in tumor regression comprised an MMAE payload with a cathepsin B cleavable linker, 2G10-RED-244-MMAE. This work demonstrates in vitro activity of the 2G10-RED-244-MMAE in TNBC cell lines and validates uPAR as a therapeutic target for TNBC